SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6fmq -
(-) 		5 / 12 HIS A 437
GLY A 430
ASN A 414
GLY A 378
MET A 456
 ACT  A 703 (-4.3A)
None
None
None
None
 1.28A 1ffyA-6fmqA:
undetectable		 1ffyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 6fmq -
(-) 		5 / 11 GLY A 524
GLN A 530
GLY A 462
GLY A 477
ARG A 415
 None
None
None
None
ACT  A 706 (-3.3A)
 1.09A 1mxgA-6fmqA:
undetectable		 1mxgA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6fmq -
(-) 		4 / 6 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.32A 1rjdA-6fmqA:
undetectable		 1rjdA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6fmq -
(-) 		4 / 6 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.30A 1rjdB-6fmqA:
undetectable		 1rjdB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6fmq -
(-) 		4 / 6 ARG A 507
ASP A 589
ASP A 587
GLU A 535
 None
 1.32A 1rjdC-6fmqA:
undetectable		 1rjdC-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 6fmq -
(-) 		4 / 5 ALA A 331
TYR A 329
ALA A 376
TYR A 396
 None
 1.11A 1xl6A-6fmqA:
undetectable
1xl6B-6fmqA:
undetectable		 1xl6A-6fmqA:
undetectable
1xl6B-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		4 / 6 SER A 431
SER A 338
GLN A 337
ASP A 389
 None
None
ACT  A 707 (-4.1A)
EDO  A 701 (-3.5A)
 1.36A 2cl5B-6fmqA:
undetectable		 2cl5B-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6fmq -
(-) 		5 / 12 HIS A 437
SER A 439
GLY A 417
VAL A 377
ALA A 376
 ACT  A 703 (-4.3A)
None
None
None
None
 1.13A 2kceB-6fmqA:
undetectable		 2kceB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 6fmq -
(-) 		4 / 4 ALA A 331
TYR A 329
ALA A 376
TYR A 396
 None
 1.09A 2wlkA-6fmqA:
undetectable
2wlkB-6fmqA:
undetectable		 2wlkA-6fmqA:
undetectable
2wlkB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fmq -
(-) 		4 / 7 ILE A 559
TYR A 584
TYR A 520
CYH A 513
 None
 1.42A 2xz5D-6fmqA:
undetectable
2xz5E-6fmqA:
undetectable		 2xz5D-6fmqA:
undetectable
2xz5E-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6fmq -
(-) 		5 / 12 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
 None
 1.18A 2y7kC-6fmqA:
undetectable		 2y7kC-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6fmq -
(-) 		5 / 12 THR A 560
ILE A 328
TYR A 329
HIS A 562
PRO A 347
 None
 1.17A 2y7kD-6fmqA:
undetectable		 2y7kD-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		4 / 6 SER A 431
SER A 338
GLN A 337
ASP A 389
 None
None
ACT  A 707 (-4.1A)
EDO  A 701 (-3.5A)
 1.35A 2zvjA-6fmqA:
undetectable		 2zvjA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6fmq -
(-) 		3 / 3 THR A 588
SER A 592
LYS A 551
 None
 0.93A 3aocC-6fmqA:
undetectable		 3aocC-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.29A 3bwmA-6fmqA:
undetectable		 3bwmA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.28A 3bwyA-6fmqA:
undetectable		 3bwyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6fmq -
(-) 		5 / 12 ALA A 376
GLY A 603
SER A 363
GLY A 379
GLY A 378
 None
ACT  A 705 ( 3.8A)
ACT  A 705 ( 4.1A)
None
None
 0.94A 3douA-6fmqA:
undetectable		 3douA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 6fmq -
(-) 		4 / 5 GLY A 379
ASP A 389
ARG A 415
GLN A 337
 None
EDO  A 701 (-3.5A)
ACT  A 706 (-3.3A)
ACT  A 707 (-4.1A)
 1.09A 3qx3A-6fmqA:
undetectable		 3qx3A-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 6fmq -
(-) 		4 / 5 GLY A 379
ASP A 389
ARG A 415
GLN A 337
 None
EDO  A 701 (-3.5A)
ACT  A 706 (-3.3A)
ACT  A 707 (-4.1A)
 1.06A 3qx3B-6fmqA:
undetectable		 3qx3B-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 6fmq -
(-) 		5 / 12 GLY A 462
ARG A 415
GLY A 429
ARG A 507
GLU A 535
 None
ACT  A 706 (-3.3A)
None
None
None
 0.95A 3tkaA-6fmqA:
undetectable		 3tkaA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 6fmq -
(-) 		5 / 12 GLY A 462
ARG A 415
GLY A 430
ARG A 507
GLU A 535
 None
ACT  A 706 (-3.3A)
None
None
None
 0.86A 3tkaA-6fmqA:
undetectable		 3tkaA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 GLY A 378
GLY A 379
SER A 431
ALA A 427
VAL A 465
 None
 0.98A 4htfA-6fmqA:
undetectable		 4htfA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 GLY A 378
GLY A 379
SER A 431
ALA A 427
VAL A 465
 None
 0.94A 4htfB-6fmqA:
undetectable		 4htfB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 6fmq -
(-) 		5 / 12 GLY A 605
GLY A 462
GLY A 603
VAL A 377
ILE A 416
 None
None
ACT  A 705 ( 3.8A)
None
None
 1.01A 4q5mA-6fmqA:
undetectable		 4q5mA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.28A 4xucA-6fmqA:
undetectable		 4xucA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.47A 4xucA-6fmqA:
undetectable		 4xucA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.26A 4xudA-6fmqA:
undetectable		 4xudA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		5 / 12 VAL A 453
GLY A 429
TYR A 490
ILE A 461
HIS A 437
 None
None
None
None
ACT  A 703 (-4.3A)
 1.27A 4xueB-6fmqA:
undetectable		 4xueB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fmq -
(-) 		3 / 3 ALA A 376
TYR A 375
PRO A 398
 None
 0.60A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fmq -
(-) 		3 / 3 ALA A 427
TYR A 426
PRO A 445
 None
 0.65A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fmq -
(-) 		3 / 3 ALA A 474
TYR A 473
PRO A 492
 None
None
ACT  A 704 (-3.6A)
 0.60A 4zdyA-6fmqA:
undetectable		 4zdyA-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6fmq -
(-) 		3 / 3 VAL A 547
THR A 545
ARG A 536
 None
 0.77A 5b2sB-6fmqA:
undetectable		 5b2sB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6fmq -
(-) 		3 / 3 VAL A 547
THR A 545
ARG A 536
 None
 0.79A 5b2tB-6fmqA:
undetectable		 5b2tB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6fmq -
(-) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
NA  A 708 ( 3.7A)
None
 1.07A 5c0oE-6fmqA:
undetectable		 5c0oE-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6fmq -
(-) 		5 / 12 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
NA  A 708 ( 3.7A)
None
 0.95A 5c0oH-6fmqA:
undetectable		 5c0oH-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6fmq -
(-) 		4 / 5 SER A 431
SER A 338
GLN A 337
ASP A 389
 None
None
ACT  A 707 (-4.1A)
EDO  A 701 (-3.5A)
 1.38A 5fhrB-6fmqA:
undetectable		 5fhrB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6fmq -
(-) 		4 / 4 LEU A 365
GLY A 364
SER A 363
SER A 338
 None
ACT  A 705 ( 3.9A)
ACT  A 705 ( 4.1A)
None
 1.12A 5uunB-6fmqA:
undetectable		 5uunB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6fmq -
(-) 		3 / 3 TYR A 396
ALA A 344
TYR A 329
 None
 0.58A 5uunB-6fmqA:
undetectable		 5uunB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 6fmq -
(-) 		4 / 7 VAL A 428
VAL A 377
GLY A 419
TYR A 426
 None
 0.89A 5x80C-6fmqA:
undetectable
5x80D-6fmqA:
undetectable		 5x80C-6fmqA:
undetectable
5x80D-6fmqA:
undetectable