SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6fn0 -
(-) 		5 / 10 ARG A 432
ILE A 446
TYR A 447
PRO A 242
GLY A 421
 None
 1.40A 13gsA-6fn0A:
undetectable		 13gsA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 6fn0 -
(-) 		5 / 9 ARG A 432
ILE A 446
TYR A 447
PRO A 242
GLY A 421
 None
 1.41A 13gsB-6fn0A:
undetectable		 13gsB-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 6fn0 -
(-) 		5 / 10 LEU A 271
LEU A 272
ALA A 269
LEU A 136
LEU A 222
 None
 1.13A 1gwrA-6fn0A:
undetectable		 1gwrA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 6fn0 -
(-) 		5 / 11 LEU A 271
LEU A 262
GLU A 223
LEU A 257
VAL A 232
 None
None
None
FAD  A 501 (-4.2A)
None
 1.22A 1ictA-6fn0A:
undetectable
1ictC-6fn0A:
undetectable		 1ictA-6fn0A:
undetectable
1ictC-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 6fn0 -
(-) 		5 / 11 LEU A 288
LEU A 262
GLU A 223
LEU A 257
THR A 251
 None
None
None
FAD  A 501 (-4.2A)
FAD  A 501 (-2.7A)
 1.20A 1ictA-6fn0A:
undetectable
1ictC-6fn0A:
undetectable		 1ictA-6fn0A:
undetectable
1ictC-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 6fn0 -
(-) 		5 / 12 ASP A 389
ARG A 360
ILE A 345
PHE A 434
ALA A 335
 FAD  A 501 (-3.8A)
FAD  A 501 (-4.0A)
None
None
None
 1.19A 1oltA-6fn0A:
undetectable		 1oltA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 6fn0 -
(-) 		4 / 4 LEU A  24
PRO A  21
LEU A  23
ARG A  73
 None
 1.32A 2hrcA-6fn0A:
undetectable		 2hrcA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 6fn0 -
(-) 		4 / 4 LEU A  24
PRO A  21
LEU A  23
ARG A  73
 None
 1.30A 2hrcB-6fn0A:
undetectable		 2hrcB-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 6fn0 -
(-) 		4 / 4 LEU A  24
PRO A  21
LEU A  23
ARG A  73
 None
 1.47A 2qd2A-6fn0A:
3.0		 2qd2A-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 6fn0 -
(-) 		4 / 8 THR A 135
ARG A  16
ASP A 391
LEU A 394
 None
None
None
FAD  A 501 (-3.8A)
 0.85A 2zw9A-6fn0A:
undetectable		 2zw9A-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 6fn0 -
(-) 		4 / 8 TYR A 109
GLU A 107
VAL A  38
ARG A 113
 None
 1.26A 3b9lA-6fn0A:
undetectable		 3b9lA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 6fn0 -
(-) 		4 / 8 HIS A 361
ASN A 398
TRP A 401
TRP A 294
 FAD  A 501 (-4.3A)
FAD  A 501 (-3.0A)
None
None
 1.07A 3ccfB-6fn0A:
2.9		 3ccfB-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6fn0 -
(-) 		5 / 12 GLN A 291
LEU A 292
SER A 263
LEU A 136
ARG A 265
 FAD  A 501 (-4.7A)
None
None
None
None
 1.43A 3fsuA-6fn0A:
undetectable		 3fsuA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6fn0 -
(-) 		5 / 12 VAL A 316
TRP A 294
PHE A 297
PHE A 298
THR A 153
 None
None
None
FAD  A 501 (-4.8A)
None
 1.40A 4iaqA-6fn0A:
undetectable		 4iaqA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 6fn0 -
(-) 		3 / 3 ARG A  16
GLU A 103
ASN A  20
 None
 0.83A 4imaD-6fn0A:
undetectable		 4imaD-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 6fn0 -
(-) 		3 / 3 ARG A  16
GLU A 103
ASN A  20
 None
 0.81A 4ip7D-6fn0A:
undetectable		 4ip7D-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 GLY A 165
VAL A 161
HIS A 268
LEU A 272
LEU A 293
 None
 0.97A 4yb6A-6fn0A:
undetectable
4yb6E-6fn0A:
undetectable		 4yb6A-6fn0A:
undetectable
4yb6E-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 GLY A 165
VAL A 161
HIS A 268
LEU A 272
LEU A 293
 None
 0.97A 4yb6B-6fn0A:
undetectable
4yb6C-6fn0A:
undetectable		 4yb6B-6fn0A:
undetectable
4yb6C-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 GLY A 165
VAL A 161
HIS A 268
LEU A 272
LEU A 293
 None
 0.96A 4yb6C-6fn0A:
undetectable
4yb6F-6fn0A:
undetectable		 4yb6C-6fn0A:
undetectable
4yb6F-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 HIS A 268
LEU A 272
LEU A 293
GLY A 165
VAL A 161
 None
 0.96A 4yb6A-6fn0A:
undetectable
4yb6D-6fn0A:
undetectable		 4yb6A-6fn0A:
undetectable
4yb6D-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 HIS A 268
LEU A 272
LEU A 293
GLY A 165
VAL A 161
 None
 0.97A 4yb6D-6fn0A:
undetectable
4yb6E-6fn0A:
undetectable		 4yb6D-6fn0A:
undetectable
4yb6E-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 6fn0 -
(-) 		5 / 10 HIS A 268
LEU A 272
LEU A 293
GLY A 165
VAL A 161
 None
 0.97A 4yb6B-6fn0A:
undetectable
4yb6F-6fn0A:
undetectable		 4yb6B-6fn0A:
undetectable
4yb6F-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 6fn0 -
(-) 		4 / 6 GLU A 223
ARG A 270
PHE A 226
PRO A 229
 None
 1.48A 6fgdA-6fn0A:
2.5		 6fgdA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6fn0 -
(-) 		3 / 3 ARG A 119
LEU A 120
PHE A  88
 None
 0.78A 6nknP-6fn0A:
undetectable		 6nknP-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6fn0 -
(-) 		3 / 3 ARG A 289
LEU A 293
PHE A 297
 None
 0.58A 6nknP-6fn0A:
undetectable		 6nknP-6fn0A:
undetectable