SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 ARG A  40
VAL A  33
ILE A 146
ALA A 357
ILE A 181
None
0.84A 1bx4A-6fn1A:
undetectable
1bx4A-6fn1A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 7 ILE A1120
ARG A1187
PHE A 266
PHE A1085
None
1.17A 1e71M-6fn1A:
undetectable
1e71M-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 7 ILE A1120
ARG A1187
PHE A 266
PHE A1085
None
1.16A 1e72M-6fn1A:
undetectable
1e72M-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 ILE A1120
ARG A1187
PHE A 266
PHE A1085
None
1.17A 1e73M-6fn1A:
undetectable
1e73M-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 LEU A 967
THR A 100
ALA A 964
LEU A 962
None
1.18A 1etb2-6fn1A:
undetectable
1etb2-6fn1A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 ARG A1221
LEU A1198
ALA A1184
GLY A1177
GLY A1178
None
0.93A 1k6cA-6fn1A:
undetectable
1k6cA-6fn1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 THR A 332
GLY A 206
GLU A  73
SER A 336
ILE A 204
None
1.46A 1odiB-6fn1A:
undetectable
1odiB-6fn1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 THR A 332
GLY A 206
GLU A  73
SER A 336
ILE A 204
None
1.41A 1odiC-6fn1A:
undetectable
1odiC-6fn1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 THR A 332
GLY A 206
GLU A  73
SER A 336
ILE A 204
None
1.46A 1odiD-6fn1A:
undetectable
1odiD-6fn1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 ARG A1221
LEU A1198
ALA A1184
GLY A1177
GLY A1178
None
0.93A 1sduA-6fn1A:
undetectable
1sduA-6fn1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 ARG A1221
LEU A1198
ALA A1184
GLY A1177
GLY A1178
None
0.93A 1sdvA-6fn1A:
undetectable
1sdvA-6fn1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 832
TYR A 997
THR A1001
SER A 695
PHE A 696
None
1.11A 1xoqA-6fn1A:
undetectable
1xoqA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 832
TYR A 997
THR A1001
SER A 695
PHE A 696
None
1.12A 1xoqB-6fn1A:
undetectable
1xoqB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
3 / 3 GLY A 609
GLU A 607
ASN A 610
None
0.71A 1zq9A-6fn1A:
undetectable
1zq9A-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 ILE A 895
TYR A 489
ARG A 488
THR A 482
None
1.03A 2einN-6fn1A:
0.3
2einW-6fn1A:
undetectable
2einN-6fn1A:
undetectable
2einW-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 MET A  38
ILE A 185
ALA A 357
ALA A 361
VAL A 364
None
0.94A 2qhfA-6fn1A:
undetectable
2qhfA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
3 / 3 LEU A 137
MET A 931
MET A 877
None
0.95A 2vavF-6fn1A:
undetectable
2vavF-6fn1A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 TYR A 789
ALA A 249
ALA A 253
LEU A 796
None
1.03A 2wx2B-6fn1A:
undetectable
2wx2B-6fn1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 MET A 196
PHE A 199
GLY A 202
GLY A 225
None
0.95A 2y6rB-6fn1A:
undetectable
2y6rB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 ILE A 460
ILE A 387
ILE A 468
GLU A 467
PRO A 384
None
1.24A 2yzqA-6fn1A:
undetectable
2yzqA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 4 VAL A 462
ASP A 456
LEU A 391
ARG A 466
None
1.26A 2ziaA-6fn1A:
1.3
2ziaA-6fn1A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 4 SER A1070
GLY A1069
GLY A1072
GLY A1248
None
0.80A 3bogB-6fn1A:
undetectable
3bogD-6fn1A:
undetectable
3bogB-6fn1A:
undetectable
3bogD-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 ILE A 460
THR A 580
SER A 418
ASN A 390
VAL A 416
None
1.43A 3burA-6fn1A:
undetectable
3burA-6fn1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 ILE A 582
ILE A 584
GLY A 426
VAL A 591
LEU A 414
None
1.41A 3elzB-6fn1A:
undetectable
3elzB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 ASN A 902
THR A 905
LEU A 909
ARG A 542
None
0.92A 3kp2A-6fn1A:
1.2
3kp2B-6fn1A:
undetectable
3kp2A-6fn1A:
undetectable
3kp2B-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 ASN A 902
THR A 905
LEU A 909
ARG A 542
None
0.98A 3kp6A-6fn1A:
undetectable
3kp6A-6fn1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 PRO A  65
ILE A  59
GLY A  61
VAL A 132
None
0.87A 3n3iA-6fn1A:
undetectable
3n3iA-6fn1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 PHE A  78
GLU A 971
SER A 969
VAL A 963
None
1.34A 3nlyA-6fn1A:
undetectable
3nlyB-6fn1A:
undetectable
3nlyA-6fn1A:
14.60
3nlyB-6fn1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 ALA A 868
ILE A 980
PHE A 982
ALA A 979
GLN A 724
None
None
ZQU  A1305 ( 4.6A)
None
ZQU  A1304 (-4.2A)
1.24A 3nmuB-6fn1A:
3.4
3nmuJ-6fn1A:
undetectable
3nmuB-6fn1A:
undetectable
3nmuJ-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
3 / 3 ALA A 571
VAL A 568
GLN A 536
None
0.68A 3of4B-6fn1A:
undetectable
3of4B-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 LEU A 858
VAL A 864
GLY A 843
ILE A 847
LEU A 861
None
1.33A 3ogpB-6fn1A:
undetectable
3ogpB-6fn1A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 VAL A1059
VAL A1078
LEU A1081
VAL A1093
LEU A1057
None
0.93A 3pghA-6fn1A:
undetectable
3pghA-6fn1A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 GLY A 603
GLY A 429
THR A 434
TYR A 400
ILE A 408
None
1.15A 3prsA-6fn1A:
undetectable
3prsA-6fn1A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 PHE A  78
GLU A 971
SER A 969
VAL A 963
None
1.33A 3rqlA-6fn1A:
2.8
3rqlB-6fn1A:
undetectable
3rqlA-6fn1A:
14.60
3rqlB-6fn1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 5 LEU A 883
GLY A 880
MET A 191
PHE A 941
None
1.03A 3uq6B-6fn1A:
undetectable
3uq6B-6fn1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 424
LEU A 409
GLY A 603
PHE A 600
ILE A 396
None
1.03A 3uwlD-6fn1A:
undetectable
3uwlD-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 4 LEU A 883
GLY A 880
MET A 191
PHE A 941
None
1.06A 3vaqB-6fn1A:
undetectable
3vaqB-6fn1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 ILE A 895
TYR A 489
ARG A 488
THR A 482
None
1.02A 3wg7N-6fn1A:
3.1
3wg7W-6fn1A:
undetectable
3wg7N-6fn1A:
undetectable
3wg7W-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 PHE A 696
GLY A 829
GLY A 826
ILE A 699
ALA A 833
None
1.04A 4a6dA-6fn1A:
undetectable
4a6dA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 PHE A 696
GLY A 829
GLY A 826
ILE A 699
ALA A 833
None
1.12A 4a6eA-6fn1A:
undetectable
4a6eA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 PHE A  78
GLU A 971
SER A 969
VAL A 963
None
1.34A 4capA-6fn1A:
undetectable
4capB-6fn1A:
undetectable
4capA-6fn1A:
14.60
4capB-6fn1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 VAL A1034
THR A1064
ILE A1114
VAL A1079
ILE A1229
None
1.41A 4eb6B-6fn1A:
undetectable
4eb6C-6fn1A:
undetectable
4eb6B-6fn1A:
11.49
4eb6C-6fn1A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 SER A1234
ARG A1232
GLY A1178
ASP A1206
None
0.95A 4koeA-6fn1A:
undetectable
4koeB-6fn1A:
undetectable
4koeC-6fn1A:
undetectable
4koeA-6fn1A:
10.55
4koeB-6fn1A:
10.55
4koeC-6fn1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 7 ARG A1232
SER A1234
GLY A1178
ASP A1206
None
0.91A 4koeA-6fn1A:
undetectable
4koeB-6fn1A:
undetectable
4koeD-6fn1A:
undetectable
4koeA-6fn1A:
10.55
4koeB-6fn1A:
10.55
4koeD-6fn1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 11 SER A 830
GLY A 829
LEU A 783
GLY A 780
LEU A 257
None
1.14A 4kt0A-6fn1A:
3.4
4kt0J-6fn1A:
1.5
4kt0A-6fn1A:
8.85
4kt0J-6fn1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 9 LEU A1259
ALA A1073
LYS A1251
GLU A1252
LEU A1065
None
1.12A 4la0B-6fn1A:
undetectable
4la0B-6fn1A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 ILE A 839
ILE A 867
GLY A 988
SER A 991
ASN A 720
None
1.10A 4o1eA-6fn1A:
undetectable
4o1eA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 ILE A 839
ILE A 867
GLY A 988
SER A 991
ASN A 720
None
1.08A 4o1eB-6fn1A:
undetectable
4o1eB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 ILE A 718
GLY A 721
ILE A 848
ILE A 839
None
0.63A 4o8fB-6fn1A:
undetectable
4o8fB-6fn1A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 5 ARG A1046
THR A1045
ASP A 804
TYR A1086
None
1.46A 4oltB-6fn1A:
undetectable
4oltB-6fn1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
6 / 11 THR A 175
ALA A 896
THR A 897
ALA A 899
GLY A 891
SER A 892
None
1.38A 4qvwK-6fn1A:
undetectable
4qvwL-6fn1A:
undetectable
4qvwK-6fn1A:
17.70
4qvwL-6fn1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
6 / 11 THR A 175
ALA A 896
THR A 897
GLY A 891
SER A 892
SER A 922
None
1.48A 4qvwK-6fn1A:
undetectable
4qvwL-6fn1A:
undetectable
4qvwK-6fn1A:
17.70
4qvwL-6fn1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
6 / 11 THR A 175
ALA A 896
THR A 897
ALA A 899
GLY A 891
SER A 892
None
1.39A 4qvwY-6fn1A:
undetectable
4qvwZ-6fn1A:
undetectable
4qvwY-6fn1A:
17.70
4qvwZ-6fn1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
6 / 11 THR A 175
ALA A 896
THR A 897
GLY A 891
SER A 892
SER A 922
None
1.48A 4qvwY-6fn1A:
undetectable
4qvwZ-6fn1A:
undetectable
4qvwY-6fn1A:
17.70
4qvwZ-6fn1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 PHE A  78
GLU A 971
SER A 969
VAL A 963
None
1.35A 4v3yA-6fn1A:
undetectable
4v3yB-6fn1A:
undetectable
4v3yA-6fn1A:
14.60
4v3yB-6fn1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 7 ILE A 895
PHE A 915
TYR A 489
ARG A 488
THR A 482
None
1.42A 5b1bN-6fn1A:
2.9
5b1bW-6fn1A:
undetectable
5b1bN-6fn1A:
undetectable
5b1bW-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 GLU A 607
LEU A 614
MET A 615
LEU A 588
None
0.96A 5dxeA-6fn1A:
3.1
5dxeA-6fn1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 7 GLY A 299
SER A 765
GLY A 762
ALA A 301
None
0.82A 5e26A-6fn1A:
undetectable
5e26B-6fn1A:
undetectable
5e26A-6fn1A:
undetectable
5e26B-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 ALA A 301
GLY A 299
SER A 765
GLY A 762
None
0.84A 5e26C-6fn1A:
undetectable
5e26D-6fn1A:
undetectable
5e26C-6fn1A:
undetectable
5e26D-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 PHE A 313
ILE A 734
PHE A 335
PHE A 982
PHE A 977
None
None
ZQU  A1304 ( 3.8A)
ZQU  A1305 ( 4.6A)
None
1.08A 5fsaA-6fn1A:
undetectable
5fsaA-6fn1A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 VAL A1059
VAL A1078
LEU A1081
VAL A1093
LEU A1057
None
1.00A 5iktB-6fn1A:
undetectable
5iktB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 GLY A1072
ASP A1199
ILE A1227
TYR A1043
None
1.13A 5iwuA-6fn1A:
undetectable
5iwuA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 9 ALA A1239
ASP A1240
ILE A1229
VAL A1244
ILE A1242
None
1.16A 5kr0A-6fn1A:
undetectable
5kr0A-6fn1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 9 ILE A 217
ALA A 219
ILE A 220
ALA A 312
LEU A 311
None
1.12A 5mvmA-6fn1A:
3.6
5mvmE-6fn1A:
1.6
5mvmA-6fn1A:
17.50
5mvmE-6fn1A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 412
LEU A 409
GLY A 603
GLY A 602
LEU A 424
None
0.97A 5uc1A-6fn1A:
undetectable
5uc1A-6fn1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 412
LEU A 409
GLY A 603
GLY A 602
LEU A 424
None
0.96A 5uc1B-6fn1A:
undetectable
5uc1B-6fn1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 PHE A 313
ILE A 734
PHE A 335
PHE A 982
PHE A 977
None
None
ZQU  A1304 ( 3.8A)
ZQU  A1305 ( 4.6A)
None
1.20A 5v5zA-6fn1A:
undetectable
5v5zA-6fn1A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
3 / 3 LYS A 289
LEU A 286
ARG A 285
None
0.95A 5yw0A-6fn1A:
undetectable
5yw0A-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 5 GLY A 190
ASP A 187
GLN A 945
MET A 948
None
None
ZQU  A1305 (-3.8A)
ZQU  A1305 (-3.4A)
1.30A 5zrfB-6fn1A:
undetectable
5zrfB-6fn1A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 6 ARG A 542
ARG A 546
LEU A 544
ALA A 571
None
0.91A 6b89B-6fn1A:
21.5
6b89B-6fn1A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
4 / 8 GLU A 607
LEU A 614
MET A 615
LEU A 588
None
1.00A 6cbzA-6fn1A:
undetectable
6cbzA-6fn1A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 10 SER A 830
GLY A 829
LEU A 783
GLY A 780
LEU A 257
None
1.21A 6hqbA-6fn1A:
4.4
6hqbJ-6fn1A:
1.4
6hqbA-6fn1A:
19.05
6hqbJ-6fn1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo
sapiens)
5 / 12 LEU A 424
LEU A 409
GLY A 603
PHE A 600
ILE A 396
None
1.08A 6qxsB-6fn1A:
undetectable
6qxsB-6fn1A:
undetectable