SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 4 HIS A 608
LEU A 626
LEU A 646
LEU A 641
 None
 1.13A 1a4lD-6fnwA:
undetectable		 1a4lD-6fnwA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.21A 1hrkA-6fnwA:
undetectable		 1hrkA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 ILE A 610
LEU A 661
PHE A 635
LEU A 646
ILE A 606
 None
 1.15A 1re7B-6fnwA:
undetectable		 1re7B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 ILE A 610
LEU A 661
PHE A 635
ILE A 629
LEU A 646
 None
 1.32A 1rh3A-6fnwA:
undetectable		 1rh3A-6fnwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 ILE A 535
ASP A 504
PHE A 502
 None
 0.57A 1uwjB-6fnwA:
undetectable		 1uwjB-6fnwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 SER A 586
LEU A 555
LEU A 549
LEU A 540
 None
 0.97A 2bfpD-6fnwA:
undetectable		 2bfpD-6fnwA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 TYR A 653
ILE A 674
ALA A 652
ILE A 632
ILE A 658
 None
 1.33A 2dm6A-6fnwA:
undetectable
2dm6B-6fnwA:
undetectable		 2dm6A-6fnwA:
16.32
2dm6B-6fnwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 448
GLY A 470
LEU A 468
ILE A 465
LEU A 474
 None
 1.12A 2f8dB-6fnwA:
undetectable		 2f8dB-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.20A 2po5A-6fnwA:
undetectable		 2po5A-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.22A 2po7A-6fnwA:
undetectable		 2po7A-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 667
LEU A 690
ILE A 629
LEU A 700
PRO A 701
 None
 1.22A 2po7B-6fnwA:
undetectable		 2po7B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.16A 2po7B-6fnwA:
undetectable		 2po7B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 430
PRO A 462
SER A 464
VAL A 459
GLY A 437
 None
None
None
None
EDO  A 904 ( 3.4A)
 1.42A 2qd2B-6fnwA:
undetectable		 2qd2B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 430
PRO A 462
SER A 464
VAL A 459
GLY A 437
 None
None
None
None
EDO  A 904 ( 3.4A)
 1.38A 2qd4B-6fnwA:
undetectable		 2qd4B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 621
LEU A 596
SER A 586
LEU A 587
LEU A 598
 None
 1.16A 2xn7A-6fnwA:
undetectable
2xn7B-6fnwA:
undetectable		 2xn7A-6fnwA:
13.27
2xn7B-6fnwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 453
LEU A 468
ILE A 465
ALA A 487
LEU A 495
 None
 1.11A 3a50D-6fnwA:
undetectable		 3a50D-6fnwA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 LEU A 692
GLN A 657
LEU A 641
LEU A 687
 None
 0.90A 3g8iA-6fnwA:
undetectable		 3g8iA-6fnwA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 9 LEU A 430
PRO A 462
SER A 464
VAL A 459
GLY A 437
 None
None
None
None
EDO  A 904 ( 3.4A)
 1.37A 3hcnB-6fnwA:
undetectable		 3hcnB-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 9 LEU A 430
PRO A 462
SER A 464
VAL A 459
GLY A 437
 None
None
None
None
EDO  A 904 ( 3.4A)
 1.43A 3hcoA-6fnwA:
undetectable		 3hcoA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 430
PRO A 462
SER A 464
VAL A 459
GLY A 437
 None
None
None
None
EDO  A 904 ( 3.4A)
 1.40A 3hcoB-6fnwA:
undetectable		 3hcoB-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 ILE A 438
PRO A 439
SER A 436
GLY A 437
LEU A 451
 None
None
EDO  A 904 (-2.9A)
EDO  A 904 ( 3.4A)
None
 1.43A 3ik6B-6fnwA:
undetectable
3ik6E-6fnwA:
undetectable		 3ik6B-6fnwA:
15.89
3ik6E-6fnwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 ARG A 600
ASP A 620
ASP A 623
 None
 0.85A 3jayA-6fnwA:
undetectable		 3jayA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 GLN A 570
GLU A 519
LYS A 547
 None
 1.19A 3su9A-6fnwA:
undetectable		 3su9A-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 PRO A 509
LEU A 515
LEU A 518
ILE A 500
 None
 0.87A 3u5jA-6fnwA:
undetectable		 3u5jA-6fnwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 ARG A 600
TYR A 668
ASN A 672
 None
EDO  A 902 (-3.9A)
None
 0.94A 4ffwB-6fnwA:
2.6		 4ffwB-6fnwA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 746
GLY A 751
LEU A 802
ILE A 759
ARG A 801
 None
 0.95A 4hytA-6fnwA:
undetectable		 4hytA-6fnwA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 746
GLY A 751
LEU A 802
ILE A 759
ARG A 801
 None
 0.96A 4hytC-6fnwA:
undetectable		 4hytC-6fnwA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 GLN A 425
ALA A 424
HIS A 522
GLU A 520
HIS A 499
 None
None
EDO  A 903 ( 4.0A)
None
None
 1.33A 4r7lA-6fnwA:
undetectable		 4r7lA-6fnwA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 VAL A 442
LEU A 474
LEU A 476
ILE A 456
VAL A 459
 None
 0.80A 4y0rA-6fnwA:
undetectable		 4y0rA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 ILE A 465
PRO A 462
ILE A 456
LEU A 495
 None
 0.83A 5ieoA-6fnwA:
undetectable		 5ieoA-6fnwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 THR A 716
HIS A 694
ASN A 670
 None
 0.86A 5n4tA-6fnwA:
undetectable		 5n4tA-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 VAL A 562
LEU A 569
LEU A 593
LEU A 551
 None
 0.75A 6g9bA-6fnwA:
undetectable
6g9bB-6fnwA:
undetectable		 6g9bA-6fnwA:
20.83
6g9bB-6fnwA:
20.88