SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		4 / 4 SER A 145
VAL A  97
PHE A   9
VAL A 183
 None
None
NA  A 301 (-4.4A)
None
 1.47A 1o86A-6fpdA:
5.6		 1o86A-6fpdA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		5 / 12 VAL A 101
LEU A 117
PHE A  92
ALA A 176
PHE A   7
 None
None
None
NA  A 301 ( 4.4A)
None
 1.23A 2jj8C-6fpdA:
undetectable		 2jj8C-6fpdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		5 / 12 SER A  26
ALA A  31
GLY A 133
ALA A 134
LEU A 138
 None
 0.76A 3ln1D-6fpdA:
undetectable		 3ln1D-6fpdA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		4 / 4 TYR A 190
THR A  80
VAL A 128
ILE A 194
 None
 1.48A 4jx1F-6fpdA:
undetectable		 4jx1F-6fpdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		4 / 6 LEU A 138
ILE A 141
LEU A 187
TYR A 190
 None
 0.94A 4w5nA-6fpdA:
undetectable		 4w5nA-6fpdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		4 / 6 LEU A 169
ILE A 152
ALA A 153
ALA A 157
 None
 0.78A 4zf8A-6fpdA:
undetectable		 4zf8A-6fpdA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		3 / 3 ASN A 143
SER A 146
SER A 145
 None
 0.67A 5gsnA-6fpdA:
undetectable		 5gsnA-6fpdA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		5 / 12 SER A  26
ALA A  31
GLY A 133
ALA A 134
LEU A 138
 None
 0.78A 5kirB-6fpdA:
undetectable		 5kirB-6fpdA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		5 / 12 VAL A 128
ALA A 134
THR A  18
GLY A  85
LEU A 187
 None
 1.20A 5m5cB-6fpdA:
undetectable		 5m5cB-6fpdA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6fpd PROTEIN AB21
(Agaricus
bisporus) 		5 / 10 VAL A 128
ALA A 134
THR A  18
GLY A  85
LEU A 187
 None
 1.20A 5m5cE-6fpdA:
undetectable		 5m5cE-6fpdA:
12.25