SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 11 ALA A 459
LEU A 518
ALA A 494
LEU A 484
SER A 492
 None
 1.22A 1tz8A-6fq3A:
undetectable
1tz8B-6fq3A:
3.6		 1tz8A-6fq3A:
20.61
1tz8B-6fq3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 11 LEU A 518
ALA A 494
LEU A 484
SER A 492
ALA A 459
 None
 1.25A 1tz8A-6fq3A:
undetectable
1tz8B-6fq3A:
3.6		 1tz8A-6fq3A:
20.61
1tz8B-6fq3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 11 THR A 720
ALA A 663
ILE A 670
ALA A 626
PHE A 711
 None
 1.20A 2admA-6fq3A:
undetectable		 2admA-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 11 THR A 720
ALA A 663
ILE A 670
ALA A 626
PHE A 711
 None
 1.17A 2admB-6fq3A:
undetectable		 2admB-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 6 PRO A 706
LEU A 728
ARG A 707
GLY A 755
 None
None
A  B   9 ( 2.9A)
None
 1.22A 2hs2B-6fq3A:
undetectable		 2hs2B-6fq3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 6 LEU A 644
VAL A 578
VAL A 662
ILE A 623
 None
 1.10A 2hyyB-6fq3A:
undetectable		 2hyyB-6fq3A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 9 GLY A 437
ALA A 438
ASP A 467
GLY A 502
ILE A 522
 None
 0.95A 2idwB-6fq3A:
undetectable		 2idwB-6fq3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 4 SER A 742
GLY A 741
GLY A 744
GLY A 746
 None
 0.86A 3bogB-6fq3A:
undetectable
3bogD-6fq3A:
undetectable		 3bogB-6fq3A:
undetectable
3bogD-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 4 THR A 806
VAL A 577
GLY A 593
THR A 594
 None
 0.98A 3cflA-6fq3A:
undetectable		 3cflA-6fq3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 6 ARG A 564
ARG A 611
ASP A 629
ARG A 707
 A  B   8 ( 3.1A)
C  B   6 ( 2.9A)
C  B   7 ( 2.5A)
A  B   9 ( 2.9A)
 1.47A 3jqzA-6fq3A:
undetectable		 3jqzA-6fq3A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		3 / 3 ASN A 584
ASP A 629
ARG A 799
 None
C  B   7 ( 2.5A)
None
 0.90A 3k13A-6fq3A:
undetectable		 3k13A-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 6 LEU A 644
VAL A 578
VAL A 662
ILE A 623
 None
 1.12A 3k5vB-6fq3A:
undetectable		 3k5vB-6fq3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 12 GLY A 477
GLY A 465
GLY A 502
LEU A 474
ALA A 438
 None
 1.02A 3kkzB-6fq3A:
undetectable		 3kkzB-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		3 / 3 TYR A 658
LEU A 682
LYS A 692
 C  B   7 ( 4.5A)
None
None
 0.60A 3sueD-6fq3A:
1.2		 3sueD-6fq3A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		3 / 3 SER A 801
ALA A 813
VAL A 812
 None
 0.63A 4o2bA-6fq3A:
undetectable		 4o2bA-6fq3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 12 VAL A 496
PHE A 461
LEU A 518
VAL A 480
SER A 493
 None
 1.29A 4po0A-6fq3A:
undetectable		 4po0A-6fq3A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		3 / 3 SER A 801
ALA A 813
VAL A 812
 None
 0.44A 4x1iA-6fq3A:
undetectable		 4x1iA-6fq3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		3 / 3 SER A 801
ALA A 813
VAL A 812
 None
 0.45A 5eypA-6fq3A:
undetectable		 5eypA-6fq3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 5 TYR A 542
GLU A 761
GLY A 539
SER A 541
 None
 1.43A 5jhdJ-6fq3A:
4.5		 5jhdJ-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 7 ILE A 811
TYR A 542
ARG A 763
GLN A 760
 None
 1.08A 5kkzC-6fq3A:
undetectable
5kkzE-6fq3A:
undetectable		 5kkzC-6fq3A:
undetectable
5kkzE-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 7 ILE A 811
TYR A 542
ARG A 763
GLN A 760
 None
 1.07A 5kkzK-6fq3A:
undetectable
5kkzQ-6fq3A:
undetectable		 5kkzK-6fq3A:
undetectable
5kkzQ-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 5 PHE A 552
SER A 551
ASN A 583
ASP A 557
 None
 1.42A 5kpcA-6fq3A:
undetectable		 5kpcA-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		4 / 7 TYR A 693
GLN A 735
ASP A 733
HIS A 716
 CL  A 906 ( 4.5A)
None
None
None
 1.32A 5ov9B-6fq3A:
undetectable		 5ov9B-6fq3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71
(Danio
rerio) 		5 / 9 ASP A 661
GLY A 755
GLY A 802
ALA A 813
VAL A 814
 None
 1.16A 5v3cA-6fq3A:
undetectable		 5v3cA-6fq3A:
23.33