SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
3 / 3 LYS A 204
ASP A 189
ASN A 197
OGA  A 506 (-2.9A)
MN  A 501 ( 2.6A)
OGA  A 506 (-3.6A)
1.13A 2bm9A-6fqcA:
undetectable
2bm9A-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 7 TYR A 137
VAL A 176
TYR A 150
ILE A 282
None
1.35A 2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 8 TYR A 137
TYR A 150
GLN A 201
ILE A 282
None
1.11A 2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
2xz5B-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 7 ILE A 282
TYR A 137
VAL A 176
TYR A 150
None
1.37A 2xz5D-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
2xz5D-6fqcA:
undetectable
2xz5E-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
5 / 10 TYR A 131
THR A 184
HIS A 187
ASP A 189
HIS A 273
None
None
MN  A 501 ( 3.4A)
MN  A 501 ( 2.6A)
MN  A 501 ( 3.1A)
1.16A 3kcxA-6fqcA:
16.2
3kcxA-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
5 / 12 PHE A  99
GLU A 139
GLY A 138
PHE A 175
ASP A 149
None
1.20A 3ps9A-6fqcA:
undetectable
3ps9A-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 5 THR A 281
GLY A 178
PRO A 180
ASN A 277
None
1.10A 3u8qA-6fqcA:
undetectable
3u8qA-6fqcA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 7 GLY A 192
ASP A 189
GLY A 269
HIS A 273
NA  A 508 ( 4.5A)
MN  A 501 ( 2.6A)
NA  A 508 (-4.2A)
MN  A 501 ( 3.1A)
0.89A 4c5nA-6fqcA:
undetectable
4c5nA-6fqcA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
4 / 7 TYR A 117
GLN A 286
THR A 264
THR A  86
None
1.05A 4mbsA-6fqcA:
undetectable
4mbsA-6fqcA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
3 / 3 TYR A 117
GLY A 178
PRO A 179
None
0.67A 4qwpA-6fqcA:
undetectable
4qwpA-6fqcA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
5 / 12 TYR A 131
PRO A 171
ASP A 189
ASN A 287
HIS A 187
None
None
MN  A 501 ( 2.6A)
OGA  A 506 ( 4.6A)
MN  A 501 ( 3.4A)
1.38A 5dv4A-6fqcA:
undetectable
5dv4A-6fqcA:
12.70