SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 8 MET A  15
GLU A 244
ASP A 247
ARG A 250
 None
 1.10A 1dtlA-6friA:
undetectable		 1dtlA-6friA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 5 GLU A 255
GLY A 251
SER A  49
PHE A  10
 None
 1.34A 1icrA-6friA:
undetectable
1icrB-6friA:
undetectable		 1icrA-6friA:
15.09
1icrB-6friA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		5 / 12 ILE A  88
GLN A  78
MET A  58
ALA A  56
GLU A  90
 None
 1.45A 1ki7A-6friA:
undetectable		 1ki7A-6friA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		5 / 12 ILE A  88
GLN A  78
MET A  58
ALA A  56
GLU A  90
 None
 1.40A 1ki7B-6friA:
undetectable		 1ki7B-6friA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		5 / 10 THR A 193
PHE A 228
LEU A 299
VAL A 232
VAL A 297
 None
 1.40A 1q23E-6friA:
undetectable		 1q23E-6friA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 4 ASP A  32
LEU A  64
LEU A  67
LEU A  71
 None
 1.32A 1u18A-6friA:
undetectable		 1u18A-6friA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		3 / 3 PHE A  42
ARG A 195
ASN A  77
 None
 0.61A 1xzxX-6friA:
undetectable		 1xzxX-6friA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		5 / 11 ILE A 141
ASN A 138
LEU A 137
VAL A  86
ALA A  89
 None
 0.94A 3dcmX-6friA:
undetectable		 3dcmX-6friA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 6 GLU A 255
PHE A 114
PHE A  48
HIS A  46
 None
 1.48A 4uciA-6friA:
undetectable		 4uciA-6friA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 7 GLU A 255
PHE A 114
PHE A  48
HIS A  46
 None
 1.46A 4uciB-6friA:
undetectable		 4uciB-6friA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6fri ALKANAL
MONOOXYGENASE BETA
CHAIN
(Photobacterium
leiognathi) 		4 / 8 LEU A 105
CYH A 133
TYR A 134
ILE A  80
 None
 0.92A 5y1yA-6friA:
undetectable		 5y1yA-6friA:
19.53