SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6frl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 8 ILE A   9
VAL A 228
ASN A 334
LEU A 363
 None
 0.98A 1dzmA-6frlA:
1.0		 1dzmA-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 6 ALA A 138
SER A 477
ARG A 491
LEU A 139
 None
 1.15A 1gahA-6frlA:
undetectable		 1gahA-6frlA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 6 TYR A 399
GLU A 346
PRO A 347
VAL A 268
 None
 1.23A 1q13A-6frlA:
undetectable		 1q13A-6frlA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 ILE A  57
PRO A  58
ILE A  86
HIS A 100
GLU A 349
 None
 0.42A 2aqjA-6frlA:
43.9		 2aqjA-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.21A 2f162-6frlA:
undetectable		 2f162-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.20A 2f16N-6frlA:
undetectable		 2f16N-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 8 TRP A 275
TRP A 240
TYR A 399
HIS A 398
 None
 1.32A 2ha2A-6frlA:
undetectable		 2ha2A-6frlA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 8 TRP A 275
TRP A 240
TYR A 399
HIS A 398
 None
 1.30A 2ha2B-6frlA:
undetectable		 2ha2B-6frlA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		7 / 12 ILE A  57
PRO A  58
LYS A  83
ILE A  86
HIS A 100
PHE A 102
GLU A 349
 None
 0.37A 2oa1A-6frlA:
43.3		 2oa1A-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 ILE A  57
PRO A  58
LYS A  83
PHE A 102
PHE A 443
 None
 1.04A 2oa1A-6frlA:
43.3		 2oa1A-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		6 / 12 ILE A  57
PRO A  58
ILE A  86
HIS A 100
PHE A 102
GLU A 349
 None
 0.38A 2oa1B-6frlA:
43.3		 2oa1B-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 10 ASP A 247
GLY A 274
SER A 272
LEU A 296
ALA A 301
 None
 0.97A 2v3kA-6frlA:
undetectable		 2v3kA-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WET_B_TRPB650_0
(TRYPTOPHAN
5-HALOGENASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 10 THR A  59
ILE A  86
HIS A 100
PHE A 102
GLU A 349
 None
 0.58A 2wetB-6frlA:
45.6		 2wetB-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 PHE A 170
VAL A  74
ALA A 354
THR A 358
MET A  23
 None
 1.32A 2x2nC-6frlA:
undetectable		 2x2nC-6frlA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1469_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 4 GLN A 300
GLU A 304
LEU A 296
SER A 297
 None
 1.36A 2xrzA-6frlA:
0.0		 2xrzA-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 4 GLY A 230
ASP A 220
GLY A 339
THR A 384
 None
None
TLA  A 601 (-3.5A)
None
 1.10A 3k4vC-6frlA:
undetectable		 3k4vC-6frlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.20A 3mg02-6frlA:
undetectable
3mg0V-6frlA:
undetectable		 3mg02-6frlA:
18.18
3mg0V-6frlA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.20A 3mg0N-6frlA:
undetectable		 3mg0N-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 5 ILE A  39
ALA A 178
HIS A  31
ARG A  33
 MES  A 602 (-4.2A)
None
None
None
 1.35A 4ac9B-6frlA:
undetectable
4ac9C-6frlA:
undetectable		 4ac9B-6frlA:
undetectable
4ac9C-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 8 PHE A 455
ARG A 414
SER A  96
ALA A 270
 None
 1.10A 4lv9A-6frlA:
undetectable
4lv9B-6frlA:
undetectable		 4lv9A-6frlA:
9.39
4lv9B-6frlA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 10 CYH A 335
LEU A 233
ALA A 232
LEU A 205
LEU A 195
 None
 1.20A 4p65A-6frlA:
undetectable
4p65B-6frlA:
undetectable
4p65F-6frlA:
undetectable
4p65H-6frlA:
undetectable		 4p65A-6frlA:
undetectable
4p65B-6frlA:
undetectable
4p65F-6frlA:
undetectable
4p65H-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 10 CYH A 335
LEU A 233
ALA A 232
LEU A 205
LEU A 195
 None
 1.27A 4p65A-6frlA:
undetectable
4p65B-6frlA:
undetectable
4p65F-6frlA:
undetectable
4p65H-6frlA:
undetectable		 4p65A-6frlA:
undetectable
4p65B-6frlA:
undetectable
4p65F-6frlA:
undetectable
4p65H-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.21A 4qvnV-6frlA:
undetectable
4qvnb-6frlA:
undetectable		 4qvnV-6frlA:
16.59
4qvnb-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 9 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.23A 4qvnK-6frlA:
undetectable
4qvnL-6frlA:
undetectable		 4qvnK-6frlA:
17.24
4qvnL-6frlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.21A 4qvnH-6frlA:
undetectable
4qvnN-6frlA:
undetectable		 4qvnH-6frlA:
16.59
4qvnN-6frlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 9 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.23A 4qvnY-6frlA:
undetectable
4qvnZ-6frlA:
undetectable		 4qvnY-6frlA:
17.24
4qvnZ-6frlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 PHE A 265
ILE A  99
LEU A 130
GLY A 136
ALA A 446
 None
 1.24A 5fctA-6frlA:
undetectable		 5fctA-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		4 / 8 ASP A 208
GLY A 223
SER A 341
VAL A  15
 None
TLA  A 601 (-3.3A)
None
None
 1.11A 6giqL-6frlA:
undetectable
6giqP-6frlA:
undetectable
6giqT-6frlA:
undetectable		 6giqL-6frlA:
undetectable
6giqP-6frlA:
undetectable
6giqT-6frlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.17A 6hwdV-6frlA:
undetectable
6hwdb-6frlA:
undetectable		 6hwdV-6frlA:
24.72
6hwdb-6frlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 12 THR A 266
THR A  81
ALA A  80
GLY A  85
ALA A 162
 None
 1.17A 6hwdH-6frlA:
undetectable
6hwdN-6frlA:
undetectable		 6hwdH-6frlA:
24.72
6hwdN-6frlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY
(Brevundimonas
sp.
BAL3) 		5 / 11 PHE A 265
ILE A  99
LEU A 130
GLY A 136
ALA A 446
 None
 1.24A 6r2eF-6frlA:
undetectable		 6r2eF-6frlA:
undetectable