SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 6fsa -
(-) 		5 / 12 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.88A 1c6yB-6fsaA:
undetectable		 1c6yB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 6fsa -
(-) 		5 / 12 ASP A 461
GLU A 328
ILE A 248
ILE A 263
PHE A 244
 None
 1.10A 1fklA-6fsaA:
undetectable		 1fklA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 6fsa -
(-) 		4 / 5 GLU A 775
LEU A 769
LEU A 772
LEU A 770
 None
 0.99A 1np1A-6fsaA:
undetectable		 1np1A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 6fsa -
(-) 		5 / 12 GLY A 759
HIS A 760
GLU A 507
PHE A 764
VAL A 763
 None
 1.32A 1qu3A-6fsaA:
undetectable		 1qu3A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6fsa -
(-) 		3 / 3 MET A 439
ASN A 232
GLN A 288
 None
MG  A2001 ( 4.5A)
None
 1.05A 1xoqB-6fsaA:
undetectable		 1xoqB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 6fsa -
(-) 		5 / 11 ILE A 285
PHE A 436
TYR A 432
ARG A 272
GLY A 231
 None
None
None
FMT  A2004 (-3.8A)
None
 1.20A 2bxmA-6fsaA:
3.1		 2bxmA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 6fsa -
(-) 		5 / 10 ILE A 285
PHE A 436
TYR A 432
ARG A 272
GLY A 231
 None
None
None
FMT  A2004 (-3.8A)
None
 1.26A 2bxqA-6fsaA:
2.8		 2bxqA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 6fsa -
(-) 		5 / 9 GLN A 315
GLY A 360
GLU A 380
ILE A 356
ALA A 428
 None
 1.38A 2drdA-6fsaA:
2.1		 2drdA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 6fsa -
(-) 		5 / 9 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.88A 2idwB-6fsaA:
undetectable		 2idwB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 6fsa -
(-) 		5 / 12 ILE A 248
ILE A 192
PHE A 195
ALA A 196
GLU A 448
 None
 0.92A 2j0dA-6fsaA:
undetectable		 2j0dA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 6fsa -
(-) 		5 / 9 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.81A 2q5kA-6fsaA:
undetectable		 2q5kA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 6fsa -
(-) 		5 / 11 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 1.04A 2qhcA-6fsaA:
undetectable		 2qhcA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 6fsa -
(-) 		5 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.94A 2r5qD-6fsaA:
undetectable		 2r5qD-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 6fsa -
(-) 		4 / 7 ASP A 599
SER A 271
LYS A 270
ASP A 282
 None
FMT  A2004 (-2.7A)
None
None
 1.26A 3bc9A-6fsaA:
undetectable		 3bc9A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 6fsa -
(-) 		5 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.80A 3ekvA-6fsaA:
undetectable		 3ekvA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 6fsa -
(-) 		6 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ALA A 196
ILE A 220
 None
 1.30A 3ekwA-6fsaA:
undetectable		 3ekwA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 6fsa -
(-) 		4 / 6 ILE A 313
TYR A 283
ILE A 356
HIS A 358
 None
 1.10A 3eteA-6fsaA:
undetectable
3eteE-6fsaA:
undetectable		 3eteA-6fsaA:
undetectable
3eteE-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 6fsa -
(-) 		4 / 5 ILE A 313
TYR A 283
ILE A 356
HIS A 358
 None
 1.08A 3eteB-6fsaA:
undetectable
3eteC-6fsaA:
undetectable		 3eteB-6fsaA:
undetectable
3eteC-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 6fsa -
(-) 		4 / 7 ILE A 356
HIS A 358
ILE A 313
TYR A 283
 None
 1.09A 3eteD-6fsaA:
undetectable
3eteF-6fsaA:
undetectable		 3eteD-6fsaA:
undetectable
3eteF-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fsa -
(-) 		5 / 10 TYR A 582
PHE A 465
GLY A 697
GLN A 475
GLY A 464
 None
 1.32A 3km6A-6fsaA:
undetectable		 3km6A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fsa -
(-) 		5 / 9 TYR A 582
PHE A 465
GLY A 697
GLN A 475
GLY A 464
 None
 1.33A 3kmoA-6fsaA:
undetectable		 3kmoA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6fsa -
(-) 		5 / 12 PHE A 230
GLU A 328
PHE A 286
ALA A 331
ILE A 289
 None
 1.32A 3ndiA-6fsaA:
undetectable		 3ndiA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 6fsa -
(-) 		5 / 9 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 1.07A 3ndwB-6fsaA:
undetectable		 3ndwB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 6fsa -
(-) 		5 / 9 ALA A 261
ASP A 262
ILE A 263
GLY A 458
ILE A 457
 None
 0.94A 3ogpA-6fsaA:
undetectable		 3ogpA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 6fsa -
(-) 		5 / 11 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 1.21A 3pghB-6fsaA:
undetectable		 3pghB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 6fsa -
(-) 		4 / 8 HIS A 284
ILE A 285
ILE A 313
ARG A 281
 None
 1.08A 3sfeB-6fsaA:
undetectable
3sfeC-6fsaA:
2.0		 3sfeB-6fsaA:
undetectable
3sfeC-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 6fsa -
(-) 		5 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.92A 3ttpA-6fsaA:
undetectable		 3ttpA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 6fsa -
(-) 		5 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.93A 3ttpB-6fsaA:
undetectable		 3ttpB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 6fsa -
(-) 		5 / 9 PRO A  14
GLY A  10
ALA A  13
ALA A   4
ASP A   3
 None
 1.42A 3ur0C-6fsaA:
undetectable		 3ur0C-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 6fsa -
(-) 		3 / 3 ASP A 461
TRP A 130
SER A 242
 None
ADP  A2002 (-3.7A)
MG  A2001 (-3.2A)
 1.03A 4lrhA-6fsaA:
undetectable		 4lrhA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 6fsa -
(-) 		4 / 8 ILE A 192
LYS A 189
ASN A 224
ALA A 223
 None
 0.95A 4ou1A-6fsaA:
undetectable		 4ou1A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6fsa -
(-) 		4 / 6 ALA A 261
GLY A 458
ILE A 220
VAL A 191
 None
 0.72A 4r21A-6fsaA:
1.6		 4r21A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6fsa -
(-) 		4 / 7 LYS A 106
LEU A 105
ASN A 686
LEU A 693
 None
 0.81A 4wg0B-6fsaA:
undetectable
4wg0C-6fsaA:
undetectable		 4wg0B-6fsaA:
undetectable
4wg0C-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6fsa -
(-) 		4 / 7 ASN A 686
LEU A 693
LYS A 106
LEU A 105
 None
 0.79A 4wg0L-6fsaA:
undetectable
4wg0M-6fsaA:
undetectable		 4wg0L-6fsaA:
undetectable
4wg0M-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fsa -
(-) 		5 / 9 PHE A 312
ILE A 356
GLY A 425
LEU A 399
LEU A 395
 None
 1.07A 4ze0A-6fsaA:
undetectable		 4ze0A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fsa -
(-) 		4 / 7 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.89A 4ze3A-6fsaA:
undetectable		 4ze3A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fsa -
(-) 		4 / 7 PHE A 312
ILE A 356
GLY A 425
LEU A 399
 None
 0.85A 5esmA-6fsaA:
1.2		 5esmA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 6fsa -
(-) 		3 / 3 THR A 481
HIS A 651
ASN A 654
 None
 0.92A 5n4tA-6fsaA:
undetectable		 5n4tA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 6fsa -
(-) 		3 / 3 HIS A 492
HIS A 666
HIS A 668
 None
 0.97A 5oexA-6fsaA:
undetectable		 5oexA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6fsa -
(-) 		5 / 12 LEU A 447
ILE A 220
GLN A 193
ILE A 154
ILE A 248
 None
 1.19A 5y2tB-6fsaA:
undetectable		 5y2tB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 6fsa -
(-) 		4 / 5 PHE A 247
THR A 660
GLU A 264
ASN A 437
 None
 1.43A 5ybbA-6fsaA:
undetectable		 5ybbA-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6fsa -
(-) 		3 / 3 TYR A 609
ASN A 602
LEU A 427
 None
 0.43A 6b58A-6fsaA:
undetectable		 6b58A-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 6fsa -
(-) 		5 / 12 PRO A 710
PHE A 765
GLN A 755
PRO A  81
PHE A  95
 None
 1.47A 6becA-6fsaA:
undetectable
6becB-6fsaA:
undetectable
6becC-6fsaA:
undetectable		 6becA-6fsaA:
undetectable
6becB-6fsaA:
undetectable
6becC-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 6fsa -
(-) 		5 / 10 ALA A 261
ASP A 262
GLY A 458
ILE A 457
ILE A 220
 None
 0.88A 6dj2A-6fsaA:
undetectable		 6dj2A-6fsaA:
undetectable