SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 7 THR A  63
SER A  62
HIS A 345
LEU A 348
 None
None
HEM  A 401 (-3.5A)
HEM  A 401 ( 4.5A)
 0.99A 1ibgL-6fshA:
undetectable		 1ibgL-6fshA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 7 PHE A 340
VAL A 241
VAL A 273
ILE A 277
 HEM  A 401 (-4.8A)
HEM  A 401 ( 4.2A)
None
None
 0.95A 1p7rA-6fshA:
35.0		 1p7rA-6fshA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.41A 1p93A-6fshA:
undetectable		 1p93A-6fshA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 252
LEU A 253
LEU A 373
GLN A 378
LEU A 364
 None
 1.34A 1sqnA-6fshA:
2.3		 1sqnA-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 GLY A 390
LEU A 252
GLY A 248
GLY A 246
LEU A 276
 None
 0.99A 2nxeB-6fshA:
undetectable		 2nxeB-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 6 LEU A 357
TRP A 365
MET A 130
LEU A 139
 None
 1.25A 2oz7A-6fshA:
undetectable		 2oz7A-6fshA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 252
LEU A 253
LEU A 373
GLN A 378
LEU A 364
 None
 1.34A 2w8yB-6fshA:
undetectable		 2w8yB-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 11 ALA A 236
LEU A  99
LEU A 103
LEU A 233
LEU A 226
 HEM  A 401 (-3.4A)
None
None
HEM  A 401 ( 4.4A)
None
 1.11A 2xn5A-6fshA:
undetectable		 2xn5A-6fshA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 GLY A 390
LEU A 252
GLY A 248
GLY A 246
LEU A 276
 None
 1.01A 2zbpA-6fshA:
undetectable		 2zbpA-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 252
LEU A 253
LEU A 373
GLN A 378
LEU A 364
 None
 1.39A 3d90A-6fshA:
undetectable		 3d90A-6fshA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.38A 3gn8A-6fshA:
undetectable		 3gn8A-6fshA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.36A 3gn8B-6fshA:
undetectable		 3gn8B-6fshA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 194
GLY A 228
GLN A 232
VAL A  85
LEU A 235
 None
 1.41A 3h52C-6fshA:
undetectable		 3h52C-6fshA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 GLY A 246
ASP A 138
ILE A 140
GLY A 390
PHE A 382
 None
 1.21A 3ps9A-6fshA:
undetectable		 3ps9A-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A 371
GLY A 246
SER A 242
GLN A 356
ILE A 140
 None
 1.18A 4djeA-6fshA:
undetectable		 4djeA-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 PHE A 190
LEU A 155
VAL A 158
ILE A 156
LEU A 194
 None
HEM  A 401 ( 4.8A)
None
None
None
 1.37A 4k38B-6fshA:
undetectable		 4k38B-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.42A 4p6xA-6fshA:
undetectable		 4p6xA-6fshA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.43A 4p6xE-6fshA:
undetectable		 4p6xE-6fshA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.36A 4p6xI-6fshA:
undetectable		 4p6xI-6fshA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.47A 4udcA-6fshA:
undetectable		 4udcA-6fshA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		3 / 3 VAL A 396
LEU A 280
MET A 244
 None
 0.69A 5ikrA-6fshA:
undetectable		 5ikrA-6fshA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 VAL A 396
LEU A 280
MET A 244
GLY A 248
LEU A 253
 None
 1.28A 5iktB-6fshA:
undetectable		 5iktB-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 VAL A 297
ALA A  45
THR A 287
GLY A  56
LEU A  55
 None
None
HEM  A 401 (-3.8A)
None
None
 1.15A 5m54E-6fshA:
undetectable		 5m54E-6fshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 VAL A 297
ALA A  45
THR A 287
GLY A  56
LEU A  55
 None
None
HEM  A 401 (-3.8A)
None
None
 1.19A 5m5cB-6fshA:
undetectable		 5m5cB-6fshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 10 VAL A 297
ALA A  45
THR A 287
GLY A  56
LEU A  55
 None
None
HEM  A 401 (-3.8A)
None
None
 1.16A 5m5cE-6fshA:
undetectable		 5m5cE-6fshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 LEU A  88
SER A 212
PHE A 107
ARG A 111
LEU A 155
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 ( 4.8A)
 1.39A 5nd2B-6fshA:
undetectable		 5nd2B-6fshA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 PHE A 209
ILE A 210
PHE A 166
HIS A 173
MET A 234
 None
 1.38A 5v5zA-6fshA:
28.1		 5v5zA-6fshA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 GLY A 206
VAL A 229
LEU A 233
GLY A 106
ILE A 213
 None
None
HEM  A 401 ( 4.4A)
None
None
 1.16A 5vooA-6fshA:
undetectable		 5vooA-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		5 / 12 GLY A 206
VAL A 229
LEU A 233
GLY A 106
ILE A 213
 None
None
HEM  A 401 ( 4.4A)
None
None
 1.14A 5vooC-6fshA:
undetectable		 5vooC-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 7 ALA A 363
THR A 362
TYR A 361
VAL A 123
 None
 0.79A 6cduA-6fshA:
undetectable
6cduE-6fshA:
undetectable		 6cduA-6fshA:
undetectable
6cduE-6fshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6fsh OXYB PROTEIN
(Actinoplanes
teichomyceticus) 		4 / 7 VAL A 123
ALA A 363
THR A 362
TYR A 361
 None
 0.81A 6cduH-6fshA:
undetectable
6cduI-6fshA:
undetectable		 6cduH-6fshA:
undetectable
6cduI-6fshA:
undetectable