SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ft5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 6ft5 -
(-) 		5 / 12 ALA A 178
GLY A 172
GLU A 111
ILE A 139
ALA A 144
 None
 1.11A 2plwA-6ft5A:
undetectable		 2plwA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6ft5 -
(-) 		3 / 3 ARG A  68
ASP A  63
ASP A  94
 GOL  A 502 (-3.9A)
None
GOL  A 501 ( 4.8A)
 0.91A 3jb2A-6ft5A:
undetectable		 3jb2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.23A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.23A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.13A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.17A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.24A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.25A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.15A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ft5 -
(-) 		5 / 11 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.19A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 6ft5 -
(-) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
GOL  A 502 (-3.7A)
 0.95A 3mteA-6ft5A:
undetectable		 3mteA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 6ft5 -
(-) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 1.00A 3mteA-6ft5A:
undetectable		 3mteA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 6ft5 -
(-) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
GOL  A 502 (-3.7A)
 1.06A 3p2kC-6ft5A:
undetectable		 3p2kC-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 6ft5 -
(-) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
GOL  A 502 (-3.7A)
 0.94A 3p2kD-6ft5A:
undetectable		 3p2kD-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 6ft5 -
(-) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 1.00A 3p2kD-6ft5A:
undetectable		 3p2kD-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6ft5 -
(-) 		3 / 3 ILE A 170
MET A 179
ARG A 176
 None
 0.80A 4lnwA-6ft5A:
undetectable		 4lnwA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6ft5 -
(-) 		3 / 3 ILE A 170
MET A 179
ARG A 176
 None
 0.80A 4lnxA-6ft5A:
undetectable		 4lnxA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ft5 -
(-) 		4 / 5 ILE A  77
ARG A  81
GLU A  49
VAL A  21
 None
 1.19A 4nkxC-6ft5A:
undetectable		 4nkxC-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ft5 -
(-) 		4 / 5 ILE A  77
ARG A  81
GLU A  49
VAL A  21
 None
 1.21A 4nkxD-6ft5A:
undetectable		 4nkxD-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6ft5 -
(-) 		4 / 8 LEU A  59
GLU A  84
LEU A 105
ILE A 108
 None
 1.01A 5mzjA-6ft5A:
3.0		 5mzjA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6ft5 -
(-) 		4 / 8 LEU A 121
GLU A 146
LEU A 167
ILE A 170
 None
 0.97A 5mzjA-6ft5A:
3.0		 5mzjA-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6ft5 -
(-) 		5 / 12 VAL A  21
GLU A  22
ALA A  51
ARG A  37
LEU A  28
 None
None
None
GOL  A 502 (-3.1A)
None
 1.38A 5nd2B-6ft5A:
undetectable		 5nd2B-6ft5A:
undetectable