SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 7 PHE A 216
GLY A 219
ILE A 439
TYR A 438
 None
 0.73A 11gsB-6fthA:
undetectable		 11gsB-6fthA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 ILE A 257
PRO A 258
ASP A 260
ILE A 191
TYR A 248
 None
 1.16A 1kijB-6fthA:
undetectable		 1kijB-6fthA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 TYR A 376
GLU A 353
GLY A 362
PHE A 392
PHE A 399
 None
 1.26A 1nw3A-6fthA:
undetectable		 1nw3A-6fthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 10 SER A 334
LEU A  92
PHE A  93
TRP A  60
LEU A  68
 None
 1.24A 1y7iB-6fthA:
undetectable		 1y7iB-6fthA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 5 ASP A 341
LEU A 344
LYS A 345
MET A 103
 None
 1.30A 2gj5A-6fthA:
undetectable		 2gj5A-6fthA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 4 LEU A 194
MET A 189
ILE A 212
ASP A 320
 None
 1.17A 3hecA-6fthA:
undetectable		 3hecA-6fthA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 VAL A  55
LEU A  68
ALA A  80
SER A  77
LEU A  23
 None
 1.08A 3n8zA-6fthA:
undetectable		 3n8zA-6fthA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 GLU A  54
GLY A 394
ASP A 397
ALA A 396
ASP A  31
 None
 1.26A 3nmuA-6fthA:
undetectable
3nmuF-6fthA:
undetectable		 3nmuA-6fthA:
undetectable
3nmuF-6fthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 6 GLU A  57
ASP A  58
SER A  56
PRO A  28
 None
 1.36A 4apjA-6fthA:
undetectable
4apjP-6fthA:
undetectable		 4apjA-6fthA:
undetectable
4apjP-6fthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 GLY A 140
ALA A 324
GLN A 143
ASN A 217
LEU A 419
 None
 1.17A 4azwA-6fthA:
undetectable		 4azwA-6fthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 5 LYS A 171
LEU A 170
GLU A 254
LEU A 251
 None
 1.25A 4k4yI-6fthA:
undetectable		 4k4yI-6fthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 8 ALA A  84
ALA A  86
ALA A 129
SER A 332
ALA A 328
 None
 1.32A 4twdF-6fthA:
undetectable
4twdG-6fthA:
undetectable
4twdH-6fthA:
undetectable
4twdI-6fthA:
undetectable
4twdJ-6fthA:
undetectable		 4twdF-6fthA:
14.29
4twdG-6fthA:
14.29
4twdH-6fthA:
14.29
4twdI-6fthA:
14.29
4twdJ-6fthA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		3 / 3 ASP A  99
ASN A 348
PHE A 109
 None
 0.68A 5dsgB-6fthA:
undetectable		 5dsgB-6fthA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 4 ALA A  61
PRO A  28
LEU A 395
HIS A  79
 None
 1.43A 5eskA-6fthA:
undetectable		 5eskA-6fthA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		5 / 12 PHE A  82
ALA A 328
ALA A  34
ALA A  39
LEU A 350
 None
 1.26A 6aycA-6fthA:
undetectable		 6aycA-6fthA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1
(Bifidobacterium
longum) 		4 / 5 VAL A 312
PRO A 305
MET A 145
VAL A 159
 None
 1.30A 6ekzA-6fthA:
undetectable		 6ekzA-6fthA:
20.48