SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ftl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 GLU A 195
ILE A 416
GLY A 419
THR A 409
GLY A 200
None
None
None
None
LYO  A 198 ( 4.4A)
1.33A 1i7qA-6ftlA:
undetectable
1i7qA-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 10 GLU A 195
ILE A 416
GLY A 419
THR A 409
GLY A 200
None
None
None
None
LYO  A 198 ( 4.4A)
1.29A 1i7qC-6ftlA:
undetectable
1i7qC-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 GLY A 336
GLY A 384
ILE A 470
ASP A 473
THR A 333
None
CAP  A 501 (-4.1A)
None
None
None
1.07A 1jg3A-6ftlA:
undetectable
1jg3A-6ftlA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 GLY A 336
GLY A 384
ILE A 470
ASP A 473
THR A 333
None
CAP  A 501 (-4.1A)
None
None
None
1.08A 1jg3B-6ftlA:
undetectable
1jg3B-6ftlA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 7 LEU A 403
MET A 270
TYR A 243
LEU A 201
HLU  A 174 ( 4.8A)
KCX  A 205 ( 3.6A)
KCX  A 205 ( 4.1A)
HLU  A 174 ( 3.6A)
1.01A 1kt3A-6ftlA:
undetectable
1kt3A-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 LEU A 352
ASP A 350
ILE A 365
GLY A 347
ARG A 315
None
1.42A 1s9aA-6ftlA:
undetectable
1s9aA-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 12 LEU A 352
ASP A 350
ILE A 365
GLY A 347
ARG A 315
None
1.44A 1s9aB-6ftlA:
undetectable
1s9aB-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 GLY A 408
ASP A 202
LYS A 175
THR A 409
GLY A 419
None
HLU  A 174 ( 3.9A)
HLU  A 174 ( 3.7A)
None
None
0.95A 2hmaA-6ftlA:
undetectable
2hmaA-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 12 LEU A 204
GLY A 241
ASP A 207
ILE A 271
LEU A 296
KCX  A 205 ( 3.9A)
None
MG  A 500 ( 2.7A)
None
None
1.15A 3eeoA-6ftlA:
undetectable
3eeoA-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 6 MET A 142
VAL A 316
ILE A 124
ILE A 312
None
0.90A 3gcsA-6ftlA:
undetectable
3gcsA-6ftlA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 8 ASP A 439
ASP A 442
GLN A 444
GLN A 392
None
1.15A 3oyaA-6ftlA:
undetectable
3oyaA-6ftlA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 12 LEU A 149
PHE A 152
PHE A 112
LEU A 120
LEU A  41
LOH  A 150 ( 4.3A)
None
None
None
None
1.30A 3tbgA-6ftlA:
undetectable
3tbgA-6ftlA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 12 LEU A 149
PHE A 152
PHE A 112
LEU A 120
LEU A  41
LOH  A 150 ( 4.3A)
None
None
None
None
1.28A 3tbgC-6ftlA:
undetectable
3tbgC-6ftlA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 6 GLY A 340
ASP A 481
ASN A 313
GLU A 140
None
0.89A 3vywC-6ftlA:
undetectable
3vywC-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 6 ASP A 478
THR A 333
ILE A 345
PHE A 314
None
1.05A 4acbC-6ftlA:
2.4
4acbC-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 GLY A  63
ALA A 103
ILE A  46
LEU A 137
LEU A 139
None
1.00A 4xumB-6ftlA:
undetectable
4xumB-6ftlA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
5 / 11 VAL A 269
PHE A 203
LEU A 166
GLY A 241
SER A 266
None
1.12A 4zbqA-6ftlA:
undetectable
4zbqA-6ftlA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 4 CYH A 387
LEU A 460
LEU A 450
ALA A 453
None
0.75A 5hpuA-6ftlA:
undetectable
5hpuB-6ftlA:
undetectable
5hpuA-6ftlA:
undetectable
5hpuB-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 8 ILE A 124
VAL A 128
ILE A  46
ALA A  88
None
0.79A 5og9A-6ftlA:
undetectable
5og9A-6ftlA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 8 GLU A 208
HIS A 330
PHE A 203
LEU A 166
MG  A 500 ( 2.7A)
CAP  A 501 (-3.8A)
None
None
1.08A 5y2tB-6ftlA:
undetectable
5y2tB-6ftlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi)
4 / 5 ARG A 138
ASP A 481
PHE A 366
ARG A 315
None
1.41A 6hxiD-6ftlA:
2.1
6hxiD-6ftlA:
undetectable