SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		3 / 3 VAL A 275
VAL A 270
TRP A 276
 None
 0.95A 1bdwA-6fvsA:
undetectable
1bdwB-6fvsA:
undetectable		 1bdwA-6fvsA:
undetectable
1bdwB-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.20A 1hrkB-6fvsA:
undetectable		 1hrkB-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		5 / 12 ALA A 229
GLY A 231
ILE A 226
ILE A 209
PHE A 217
 None
BNG  A 401 ( 2.9A)
None
BNG  A 401 ( 4.8A)
None
 1.13A 1ve3B-6fvsA:
undetectable		 1ve3B-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		5 / 11 PHE A 117
ILE A  23
GLY A  22
ILE A  17
PHE A 189
 None
 0.94A 1z11B-6fvsA:
undetectable		 1z11B-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		3 / 3 TRP A  75
ARG A  74
PHE A 137
 None
 0.90A 1zeaH-6fvsA:
2.5
1zeaL-6fvsA:
3.1		 1zeaH-6fvsA:
undetectable
1zeaL-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.37A 2hrcA-6fvsA:
undetectable		 2hrcA-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.23A 2hrcB-6fvsA:
undetectable		 2hrcB-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.29A 2pnjB-6fvsA:
undetectable		 2pnjB-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 5 GLN A  25
PHE A 117
PHE A 129
GLY A  22
 None
 1.40A 2qmzA-6fvsA:
undetectable
2qmzB-6fvsA:
undetectable		 2qmzA-6fvsA:
14.35
2qmzB-6fvsA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		4 / 5 TYR A 104
ILE A  94
LEU A  68
LEU A  65
 None
 1.04A 2zb7A-6fvsA:
undetectable		 2zb7A-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		5 / 12 GLU A 106
PHE A  78
LEU A 153
GLY A  34
GLN A  83
 None
 1.44A 4djeA-6fvsA:
undetectable		 4djeA-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		5 / 12 ILE A 209
LEU A 233
PHE A 236
ILE A 266
ILE A 210
 BNG  A 401 ( 4.8A)
None
None
None
None
 1.13A 4ptjA-6fvsA:
undetectable		 4ptjA-6fvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL
(endosymbiont
of
Tevnia
jerichonana) 		3 / 3 SER A 183
ALA A 182
THR A 178
 None
 0.69A 5n0xB-6fvsA:
undetectable		 5n0xB-6fvsA:
undetectable