SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fwh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		3 / 3 GLU A  70
HIS A  66
HIS A 138
 MN  A 202 ( 2.7A)
MN  A 202 ( 3.4A)
MN  A 202 (-3.5A)
 0.42A 1oe2A-6fwhA:
undetectable		 1oe2A-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		3 / 3 GLU A 166
HIS A 162
HIS A  40
 MN  A 201 ( 2.6A)
MN  A 201 ( 3.5A)
MN  A 201 ( 3.5A)
 0.31A 1oe2A-6fwhA:
undetectable		 1oe2A-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 6 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.87A 1rs7B-6fwhA:
undetectable		 1rs7B-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		5 / 11 GLY A  77
ALA A  79
PHE A  80
ALA A  83
LEU A  23
 None
 1.10A 1ukbA-6fwhA:
undetectable		 1ukbA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 6 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 2e1qA-6fwhA:
undetectable		 2e1qA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 6 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 2e1qC-6fwhA:
undetectable		 2e1qC-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 7 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 3uniA-6fwhA:
3.0		 3uniA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 6 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.84A 4d39B-6fwhA:
undetectable		 4d39B-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		5 / 12 ALA A  79
LEU A  53
PHE A 143
PHE A 169
VAL A 153
 None
 1.24A 4eckA-6fwhA:
undetectable		 4eckA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 8 ASP A  71
ASP A  64
ASP A  60
GLU A  70
 None
None
None
MN  A 202 ( 2.7A)
 1.05A 4gkiE-6fwhA:
undetectable
4gkiG-6fwhA:
undetectable		 4gkiE-6fwhA:
undetectable
4gkiG-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 6 GLY A  77
ILE A  74
GLN A  78
VAL A  19
 None
 0.89A 4kcnA-6fwhA:
undetectable		 4kcnA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		5 / 9 PHE A  51
LEU A  21
THR A 172
VAL A 109
LEU A 151
 None
 1.41A 4wnvA-6fwhA:
undetectable		 4wnvA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		5 / 12 PHE A 169
LEU A 123
ALA A 165
ILE A 119
LEU A 176
 None
 1.40A 5ljbA-6fwhA:
undetectable		 5ljbA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		4 / 7 HIS A  66
HIS A 138
VAL A 139
SER A 142
 MN  A 202 ( 3.4A)
MN  A 202 (-3.5A)
None
None
 1.04A 5m8rA-6fwhA:
undetectable		 5m8rA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Acanthamoeba
castellanii) 		5 / 7 PHE A 169
GLY A  77
ALA A 147
VAL A 180
LEU A 176
 None
 1.35A 6dwnB-6fwhA:
undetectable		 6dwnB-6fwhA:
undetectable