SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		4 / 5 PHE A  26
PHE A  68
ILE A  90
THR A  46
 None
 1.04A 4ejjC-6fx4A:
undetectable		 4ejjC-6fx4A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		5 / 12 ASP A  91
ALA A 108
PHE A  44
LEU A  67
PHE A  68
 None
 1.25A 4iaqA-6fx4A:
undetectable		 4iaqA-6fx4A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		3 / 3 LYS A  14
HIS A  71
HIS A  15
 None
 0.73A 5oexA-6fx4A:
undetectable		 5oexA-6fx4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		3 / 3 LYS A  14
HIS A  71
HIS A  15
 None
 0.74A 5oexB-6fx4A:
undetectable		 5oexB-6fx4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		3 / 3 LYS A  14
HIS A  71
HIS A  15
 None
 0.75A 5oexC-6fx4A:
undetectable		 5oexC-6fx4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 6fx4 E3 UBIQUITIN-PROTEIN
LIGASE SMURF2
(Homo
sapiens) 		3 / 3 LYS A  14
HIS A  71
HIS A  15
 None
 0.74A 5oexD-6fx4A:
undetectable		 5oexD-6fx4A:
undetectable