SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6fyh E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 SER A 315
VAL A 317
THR A 277
ILE A 268
PHE A 322
 None
 1.39A 2vdyA-6fyhA:
undetectable		 2vdyA-6fyhA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 6fyh E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 ILE A 289
LEU A 371
LEU A 356
GLN A 355
LEU A 273
 None
 1.18A 3ix9A-6fyhA:
undetectable		 3ix9A-6fyhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 6fyh E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE A 310
PHE A 307
THR A 351
PHE A 334
 None
 1.00A 3vnsA-6fyhA:
undetectable		 3vnsA-6fyhA:
undetectable