SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
VAL A 225
ASN A 293
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
None
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.76A 1fmoE-6fyoA:
25.4		 1fmoE-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 209
VAL A 225
ILE A 239
LEU A 295
 None
None
None
EAQ  A 501 (-4.9A)
 0.89A 1iepB-6fyoA:
21.5		 1iepB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 11 LEU A 458
VAL A 378
PRO A 435
PHE A 439
LEU A 436
 None
 1.39A 1klmA-6fyoA:
undetectable		 1klmA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.45A 1lzxA-6fyoA:
undetectable
1lzxB-6fyoA:
undetectable		 1lzxA-6fyoA:
undetectable
1lzxB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 1opjB-6fyoA:
21.2		 1opjB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 TRP A 356
VAL A 350
ALA A 347
SER A 364
 None
 0.90A 1p6kA-6fyoA:
undetectable		 1p6kA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.46A 1p6kA-6fyoA:
undetectable
1p6kB-6fyoA:
undetectable		 1p6kA-6fyoA:
undetectable
1p6kB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.46A 1p6kA-6fyoA:
undetectable
1p6kB-6fyoA:
undetectable		 1p6kA-6fyoA:
undetectable
1p6kB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.27A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
VAL A 225
GLY A 245
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.6A)
 1.16A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.10A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
VAL A 225
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
 0.91A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 ASN A 293
HIS A 286
PHE A 326
ILE A 272
 None
 1.23A 1tdnA-6fyoA:
undetectable		 1tdnA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 VAL A 175
LYS A 191
VAL A 225
PHE A 241
ASN A 293
LEU A 295
ASP A 325
 None
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-3.5A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.66A 2eufB-6fyoA:
31.1		 2eufB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.75A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.66A 2hyyC-6fyoA:
21.9		 2hyyC-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.9A)
 0.62A 2y7jD-6fyoA:
27.7		 2y7jD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.65A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.61A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.6A)
 0.96A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
EAQ  A 501 (-4.9A)
 0.90A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
LEU A 295
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.9A)
None
 0.75A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.66A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.60A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 210
GLU A 206
LEU A 284
LEU A 279
HIS A 286
 None
EAQ  A 501 (-3.4A)
None
None
None
 1.25A 3g1uA-6fyoA:
undetectable		 3g1uA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.65A 3ik3A-6fyoA:
21.4		 3ik3A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3ik3B-6fyoA:
21.2		 3ik3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.74A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.67A 3k5vB-6fyoA:
21.0		 3k5vB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.82A 3k5vB-6fyoA:
21.0		 3k5vB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
SER A 247
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.70A 3lxnA-6fyoA:
24.4		 3lxnA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.79A 3mssA-6fyoA:
21.5		 3mssA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.81A 3mssB-6fyoA:
21.4		 3mssB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 6 VAL A 175
LYS A 191
VAL A 209
VAL A 225
ILE A 239
 None
EAQ  A 501 (-3.2A)
None
None
None
 0.76A 3mssD-6fyoA:
21.4		 3mssD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.49A 3n5vA-6fyoA:
undetectable
3n5vB-6fyoA:
undetectable		 3n5vA-6fyoA:
undetectable
3n5vB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.49A 3n65A-6fyoA:
undetectable
3n65B-6fyoA:
undetectable		 3n65A-6fyoA:
undetectable
3n65B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 209
ILE A 239
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-4.9A)
 0.91A 3oezB-6fyoA:
22.0		 3oezB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
LYS A 191
VAL A 209
ILE A 239
LEU A 295
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
EAQ  A 501 (-4.9A)
 0.90A 3oxzA-6fyoA:
21.6		 3oxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 209
ILE A 239
LEU A 295
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-4.9A)
None
 0.93A 3oxzA-6fyoA:
21.6		 3oxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.72A 3pyyA-6fyoA:
21.2		 3pyyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.42A 3ufpA-6fyoA:
undetectable
3ufpB-6fyoA:
undetectable		 3ufpA-6fyoA:
undetectable
3ufpB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.49A 3ufpA-6fyoA:
undetectable
3ufpB-6fyoA:
undetectable		 3ufpA-6fyoA:
undetectable
3ufpB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.48A 3ufqA-6fyoA:
undetectable
3ufqB-6fyoA:
undetectable		 3ufqA-6fyoA:
undetectable
3ufqB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.46A 3ufrA-6fyoA:
undetectable
3ufrB-6fyoA:
undetectable		 3ufrA-6fyoA:
undetectable
3ufrB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.46A 3ufsA-6fyoA:
undetectable
3ufsB-6fyoA:
undetectable		 3ufsA-6fyoA:
undetectable
3ufsB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.51A 3warA-6fyoA:
29.1		 3warA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		9 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 279
HIS A 286
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
None
 1.26A 4asdA-6fyoA:
21.8		 4asdA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 ILE A 294
LEU A 244
GLU A 242
PHE A 326
HIS A 286
 None
EAQ  A 501 (-4.3A)
None
None
None
 1.12A 4b9zA-6fyoA:
undetectable		 4b9zA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.44A 4c39A-6fyoA:
undetectable
4c39B-6fyoA:
undetectable		 4c39A-6fyoA:
undetectable
4c39B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 4c39A-6fyoA:
undetectable
4c39B-6fyoA:
undetectable		 4c39A-6fyoA:
undetectable
4c39B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-4.9A)
 0.37A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
SER A 247
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
None
 0.38A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 4ctpA-6fyoA:
undetectable
4ctpB-6fyoA:
undetectable		 4ctpA-6fyoA:
undetectable
4ctpB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 4ctqA-6fyoA:
undetectable
4ctqB-6fyoA:
undetectable		 4ctqA-6fyoA:
undetectable
4ctqB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.39A 4cx6A-6fyoA:
undetectable
4cx6B-6fyoA:
undetectable		 4cx6A-6fyoA:
undetectable
4cx6B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.47A 4d1nC-6fyoA:
undetectable
4d1nD-6fyoA:
undetectable		 4d1nC-6fyoA:
undetectable
4d1nD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASP A 250
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.79A 4i22A-6fyoA:
20.9		 4i22A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 11 VAL A 175
ALA A 189
LYS A 191
GLU A 292
LEU A 295
ASP A 325
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.97A 4iaaA-6fyoA:
25.0		 4iaaA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 4jsfA-6fyoA:
undetectable
4jsfB-6fyoA:
undetectable		 4jsfA-6fyoA:
undetectable
4jsfB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.42A 4jsgA-6fyoA:
undetectable
4jsgB-6fyoA:
undetectable		 4jsgA-6fyoA:
undetectable
4jsgB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.44A 4k5dA-6fyoA:
undetectable
4k5dB-6fyoA:
undetectable		 4k5dA-6fyoA:
undetectable
4k5dB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 4k5gA-6fyoA:
undetectable
4k5gB-6fyoA:
undetectable		 4k5gA-6fyoA:
undetectable
4k5gB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.44A 4luxA-6fyoA:
undetectable
4luxB-6fyoA:
undetectable		 4luxA-6fyoA:
undetectable
4luxB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
 0.64A 4mxoA-6fyoA:
24.0		 4mxoA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.81A 4mxyA-6fyoA:
24.4		 4mxyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.81A 4mxzA-6fyoA:
24.4		 4mxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 11 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASN A 293
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.68A 4o0sA-6fyoA:
26.7		 4o0sA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 6 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-4.9A)
 0.52A 4o0wA-6fyoA:
25.3		 4o0wA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
GLY A 168
GLY A 173
VAL A 175
ALA A 189
LYS A 191
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.9A)
 0.50A 4otiA-6fyoA:
21.0		 4otiA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.39A 4ugzA-6fyoA:
undetectable
4ugzB-6fyoA:
undetectable		 4ugzA-6fyoA:
undetectable
4ugzB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.32A 4uh0A-6fyoA:
undetectable
4uh0B-6fyoA:
undetectable		 4uh0A-6fyoA:
undetectable
4uh0B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 4uh2A-6fyoA:
undetectable
4uh2B-6fyoA:
undetectable		 4uh2A-6fyoA:
undetectable
4uh2B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 4uh3A-6fyoA:
undetectable
4uh3B-6fyoA:
undetectable		 4uh3A-6fyoA:
undetectable
4uh3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.45A 4uh4A-6fyoA:
undetectable
4uh4B-6fyoA:
undetectable		 4uh4A-6fyoA:
undetectable
4uh4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.37A 4uh5A-6fyoA:
undetectable
4uh5B-6fyoA:
undetectable		 4uh5A-6fyoA:
undetectable
4uh5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.39A 4uh6A-6fyoA:
undetectable
4uh6B-6fyoA:
undetectable		 4uh6A-6fyoA:
undetectable
4uh6B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 4uh6A-6fyoA:
undetectable
4uh6B-6fyoA:
undetectable		 4uh6A-6fyoA:
undetectable
4uh6B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.41A 4v3wA-6fyoA:
0.5
4v3wB-6fyoA:
undetectable		 4v3wA-6fyoA:
undetectable
4v3wB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.18A 4wkqA-6fyoA:
23.7		 4wkqA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.43A 5ad4A-6fyoA:
undetectable
5ad4B-6fyoA:
undetectable		 5ad4A-6fyoA:
undetectable
5ad4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.42A 5ad4A-6fyoA:
undetectable
5ad4B-6fyoA:
undetectable		 5ad4A-6fyoA:
undetectable
5ad4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.34A 5ad5A-6fyoA:
undetectable
5ad5B-6fyoA:
undetectable		 5ad5A-6fyoA:
undetectable
5ad5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 5ad6A-6fyoA:
undetectable
5ad6B-6fyoA:
undetectable		 5ad6A-6fyoA:
undetectable
5ad6B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 5adaA-6fyoA:
undetectable
5adaB-6fyoA:
undetectable		 5adaA-6fyoA:
undetectable
5adaB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 5adaA-6fyoA:
undetectable
5adaB-6fyoA:
undetectable		 5adaA-6fyoA:
undetectable
5adaB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.49A 5adfA-6fyoA:
undetectable
5adfB-6fyoA:
undetectable		 5adfA-6fyoA:
undetectable
5adfB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 5adgA-6fyoA:
undetectable
5adgB-6fyoA:
undetectable		 5adgA-6fyoA:
undetectable
5adgB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 5adgA-6fyoA:
undetectable
5adgB-6fyoA:
undetectable		 5adgA-6fyoA:
undetectable
5adgB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 5adiA-6fyoA:
undetectable
5adiB-6fyoA:
undetectable		 5adiA-6fyoA:
undetectable
5adiB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.46A 5fvqA-6fyoA:
undetectable
5fvqB-6fyoA:
undetectable		 5fvqA-6fyoA:
undetectable
5fvqB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.44A 5fvsA-6fyoA:
undetectable
5fvsB-6fyoA:
undetectable		 5fvsA-6fyoA:
undetectable
5fvsB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.32A 5fvtA-6fyoA:
undetectable
5fvtB-6fyoA:
undetectable		 5fvtA-6fyoA:
undetectable
5fvtB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.39A 5fvuA-6fyoA:
undetectable
5fvuB-6fyoA:
undetectable		 5fvuA-6fyoA:
undetectable
5fvuB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.44A 5fvvA-6fyoA:
undetectable
5fvvB-6fyoA:
undetectable		 5fvvA-6fyoA:
undetectable
5fvvB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 5fvvA-6fyoA:
undetectable
5fvvB-6fyoA:
undetectable		 5fvvA-6fyoA:
undetectable
5fvvB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 5fvwA-6fyoA:
undetectable
5fvwB-6fyoA:
undetectable		 5fvwA-6fyoA:
undetectable
5fvwB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 5fvwA-6fyoA:
undetectable
5fvwB-6fyoA:
undetectable		 5fvwA-6fyoA:
undetectable
5fvwB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 5fvxA-6fyoA:
undetectable
5fvxB-6fyoA:
undetectable		 5fvxA-6fyoA:
undetectable
5fvxB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 5fw0A-6fyoA:
undetectable
5fw0B-6fyoA:
undetectable		 5fw0A-6fyoA:
undetectable
5fw0B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.45A 5g0nA-6fyoA:
undetectable
5g0nB-6fyoA:
undetectable		 5g0nA-6fyoA:
undetectable
5g0nB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 5g0nA-6fyoA:
undetectable
5g0nB-6fyoA:
undetectable		 5g0nA-6fyoA:
undetectable
5g0nB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.46A 5g0oA-6fyoA:
undetectable
5g0oB-6fyoA:
undetectable		 5g0oA-6fyoA:
undetectable
5g0oB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 LEU A 167
VAL A 175
ALA A 189
ILE A 239
LEU A 243
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
 0.54A 5h2uD-6fyoA:
21.3		 5h2uD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 VAL A 175
ALA A 189
LYS A 191
ILE A 239
ASP A 250
GLY A 327
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
None
None
 0.97A 5hesB-6fyoA:
20.7		 5hesB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
GLU A 254
LEU A 295
 EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-4.9A)
 1.29A 5i9xA-6fyoA:
22.7		 5i9xA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 7 GLY A 168
GLY A 170
VAL A 175
LYS A 191
ASP A 325
 None
None
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.6A)
 0.70A 5j5xA-6fyoA:
25.7		 5j5xA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 GLY A 168
VAL A 175
ALA A 189
VAL A 225
PHE A 241
LEU A 295
 None
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.9A)
 0.64A 5l2iA-6fyoA:
9.9		 5l2iA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
 0.42A 5mo4A-6fyoA:
18.8		 5mo4A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.49A 5unrA-6fyoA:
undetectable
5unrB-6fyoA:
undetectable		 5unrA-6fyoA:
undetectable
5unrB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.47A 5untA-6fyoA:
undetectable
5untB-6fyoA:
undetectable		 5untA-6fyoA:
undetectable
5untB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 5untA-6fyoA:
undetectable
5untB-6fyoA:
undetectable		 5untA-6fyoA:
undetectable
5untB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.40A 5unuA-6fyoA:
undetectable
5unuB-6fyoA:
undetectable		 5unuA-6fyoA:
undetectable
5unuB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 5unuA-6fyoA:
undetectable
5unuB-6fyoA:
undetectable		 5unuA-6fyoA:
undetectable
5unuB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.45A 5unwA-6fyoA:
undetectable
5unwB-6fyoA:
undetectable		 5unwA-6fyoA:
undetectable
5unwB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.40A 5unwA-6fyoA:
undetectable
5unwB-6fyoA:
undetectable		 5unwA-6fyoA:
undetectable
5unwB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.30A 5unxA-6fyoA:
undetectable
5unxB-6fyoA:
undetectable		 5unxA-6fyoA:
undetectable
5unxB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.42A 5unyA-6fyoA:
undetectable
5unyB-6fyoA:
undetectable		 5unyA-6fyoA:
undetectable
5unyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 5unyA-6fyoA:
undetectable
5unyB-6fyoA:
undetectable		 5unyA-6fyoA:
undetectable
5unyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.46A 5unzA-6fyoA:
undetectable
5unzB-6fyoA:
undetectable		 5unzA-6fyoA:
undetectable
5unzB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.41A 5uo1A-6fyoA:
undetectable
5uo1B-6fyoA:
undetectable		 5uo1A-6fyoA:
undetectable
5uo1B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 5uo1A-6fyoA:
undetectable
5uo1B-6fyoA:
undetectable		 5uo1A-6fyoA:
undetectable
5uo1B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 5uo2A-6fyoA:
undetectable
5uo2B-6fyoA:
undetectable		 5uo2A-6fyoA:
undetectable
5uo2B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.33A 5uo3A-6fyoA:
undetectable
5uo3B-6fyoA:
undetectable		 5uo3A-6fyoA:
undetectable
5uo3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.32A 5uo3A-6fyoA:
undetectable
5uo3B-6fyoA:
undetectable		 5uo3A-6fyoA:
undetectable
5uo3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 5uo4A-6fyoA:
undetectable
5uo4B-6fyoA:
undetectable		 5uo4A-6fyoA:
undetectable
5uo4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 5uo5A-6fyoA:
undetectable
5uo5B-6fyoA:
undetectable		 5uo5A-6fyoA:
undetectable
5uo5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 5uo5A-6fyoA:
undetectable
5uo5B-6fyoA:
undetectable		 5uo5A-6fyoA:
undetectable
5uo5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 5uo6A-6fyoA:
undetectable
5uo6B-6fyoA:
undetectable		 5uo6A-6fyoA:
undetectable
5uo6B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 8 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.33A 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable		 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable		 5uo7A-6fyoA:
undetectable
5uo7B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 4 VAL A 225
LEU A 243
ASN A 293
ASP A 325
 None
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.6A)
 0.95A 5vcyA-6fyoA:
26.7		 5vcyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.41A 5vuiA-6fyoA:
undetectable
5vuiB-6fyoA:
undetectable		 5vuiA-6fyoA:
undetectable
5vuiB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 5vuiA-6fyoA:
undetectable
5vuiB-6fyoA:
undetectable		 5vuiA-6fyoA:
undetectable
5vuiB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.49A 5vumA-6fyoA:
undetectable
5vumB-6fyoA:
undetectable		 5vumA-6fyoA:
undetectable
5vumB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.49A 5vusA-6fyoA:
undetectable
5vusB-6fyoA:
undetectable		 5vusA-6fyoA:
undetectable
5vusB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 5vuvA-6fyoA:
undetectable
5vuvB-6fyoA:
undetectable		 5vuvA-6fyoA:
undetectable
5vuvB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.41A 5vuzA-6fyoA:
undetectable
5vuzB-6fyoA:
undetectable		 5vuzA-6fyoA:
undetectable
5vuzB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 5vv3A-6fyoA:
undetectable
5vv3B-6fyoA:
undetectable		 5vv3A-6fyoA:
undetectable
5vv3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 5vv4A-6fyoA:
undetectable
5vv4B-6fyoA:
undetectable		 5vv4A-6fyoA:
undetectable
5vv4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 5 LEU A 352
TYR A 460
LEU A 388
GLU A 392
 None
 1.30A 5weaA-6fyoA:
undetectable		 5weaA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
PHE A 241
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
 0.13A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 167
VAL A 175
ALA A 189
PHE A 241
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-3.9A)
 0.58A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 0.87A 5y7zA-6fyoA:
25.0		 5y7zA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.87A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.97A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.00A 5y80A-6fyoA:
23.9		 5y80A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.35A 5y9mX-6fyoA:
22.3		 5y9mX-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.54A 5yf9B-6fyoA:
27.9		 5yf9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.50A 5ywmX-6fyoA:
27.8		 5ywmX-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.39A 6auqA-6fyoA:
undetectable
6auqB-6fyoA:
undetectable		 6auqA-6fyoA:
undetectable
6auqB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.34A 6aurA-6fyoA:
undetectable
6aurB-6fyoA:
undetectable		 6aurA-6fyoA:
undetectable
6aurB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 6aurA-6fyoA:
undetectable
6aurB-6fyoA:
undetectable		 6aurA-6fyoA:
undetectable
6aurB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.47A 6ausA-6fyoA:
undetectable
6ausB-6fyoA:
undetectable		 6ausA-6fyoA:
undetectable
6ausB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.33A 6autA-6fyoA:
undetectable
6autB-6fyoA:
undetectable		 6autA-6fyoA:
undetectable
6autB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 6autA-6fyoA:
undetectable
6autB-6fyoA:
undetectable		 6autA-6fyoA:
undetectable
6autB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.32A 6auuA-6fyoA:
undetectable
6auuB-6fyoA:
undetectable		 6auuA-6fyoA:
undetectable
6auuB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.43A 6auvA-6fyoA:
undetectable
6auvB-6fyoA:
undetectable		 6auvA-6fyoA:
undetectable
6auvB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.49A 6auxA-6fyoA:
undetectable
6auxB-6fyoA:
undetectable		 6auxA-6fyoA:
undetectable
6auxB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 6auyA-6fyoA:
undetectable
6auyB-6fyoA:
undetectable		 6auyA-6fyoA:
undetectable
6auyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.37A 6auzA-6fyoA:
undetectable
6auzB-6fyoA:
undetectable		 6auzA-6fyoA:
undetectable
6auzB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 6auzA-6fyoA:
undetectable
6auzB-6fyoA:
undetectable		 6auzA-6fyoA:
undetectable
6auzB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.46A 6av0A-6fyoA:
undetectable
6av0B-6fyoA:
undetectable		 6av0A-6fyoA:
undetectable
6av0B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 6av0A-6fyoA:
undetectable
6av0B-6fyoA:
undetectable		 6av0A-6fyoA:
undetectable
6av0B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.38A 6av1A-6fyoA:
undetectable
6av1B-6fyoA:
undetectable		 6av1A-6fyoA:
undetectable
6av1B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.44A 6av1A-6fyoA:
undetectable
6av1B-6fyoA:
undetectable		 6av1A-6fyoA:
undetectable
6av1B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 6av2A-6fyoA:
undetectable
6av2B-6fyoA:
undetectable		 6av2A-6fyoA:
undetectable
6av2B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.37A 6av3A-6fyoA:
undetectable
6av3B-6fyoA:
undetectable		 6av3A-6fyoA:
undetectable
6av3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 6av4A-6fyoA:
undetectable
6av4B-6fyoA:
undetectable		 6av4A-6fyoA:
undetectable
6av4B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.37A 6av5A-6fyoA:
undetectable
6av5B-6fyoA:
undetectable		 6av5A-6fyoA:
undetectable
6av5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 6av5A-6fyoA:
undetectable
6av5B-6fyoA:
undetectable		 6av5A-6fyoA:
undetectable
6av5B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.40A 6cicA-6fyoA:
undetectable
6cicB-6fyoA:
undetectable		 6cicA-6fyoA:
undetectable
6cicB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.38A 6cicA-6fyoA:
undetectable
6cicB-6fyoA:
undetectable		 6cicA-6fyoA:
undetectable
6cicB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 6cidA-6fyoA:
undetectable
6cidB-6fyoA:
undetectable		 6cidA-6fyoA:
undetectable
6cidB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 6cidA-6fyoA:
undetectable
6cidB-6fyoA:
undetectable		 6cidA-6fyoA:
undetectable
6cidB-6fyoA:
undetectable