SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
VAL A 225
ASN A 293
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
None
None
None
3NG  A 501 (-4.3A)
 0.78A 1fmoE-6fyvA:
25.5		 1fmoE-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 VAL A 209
VAL A 225
ILE A 239
LEU A 295
 None
 0.87A 1iepB-6fyvA:
21.8		 1iepB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 11 LEU A 458
VAL A 378
PRO A 435
PHE A 439
LEU A 436
 None
 1.41A 1klmA-6fyvA:
undetectable		 1klmA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.60A 1opjB-6fyvA:
21.3		 1opjB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 TRP A 356
VAL A 350
ALA A 347
SER A 364
 None
 0.94A 1p6kA-6fyvA:
undetectable		 1p6kA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 1p6kA-6fyvA:
undetectable
1p6kB-6fyvA:
undetectable		 1p6kA-6fyvA:
undetectable
1p6kB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 1p6kA-6fyvA:
undetectable
1p6kB-6fyvA:
undetectable		 1p6kA-6fyvA:
undetectable
1p6kB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		9 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
3NG  A 501 (-4.3A)
 1.07A 1t46A-6fyvA:
22.2		 1t46A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		9 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
VAL A 225
GLY A 245
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
3NG  A 501 (-4.3A)
 0.90A 1t46A-6fyvA:
22.2		 1t46A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 ASN A 293
HIS A 286
PHE A 326
ILE A 272
 None
 1.23A 1tdnA-6fyvA:
undetectable		 1tdnA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 ALA A 189
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
None
 0.68A 1uwhA-6fyvA:
22.5		 1uwhA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 12 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.67A 1uwhB-6fyvA:
22.4		 1uwhB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 LEU A 436
LEU A 395
GLY A 366
CYH A 273
ALA A 471
 None
 1.34A 2bm9B-6fyvA:
undetectable		 2bm9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 VAL A 175
LYS A 191
VAL A 225
PHE A 241
ASN A 293
LEU A 295
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
3NG  A 501 (-3.5A)
None
None
3NG  A 501 (-4.3A)
 0.68A 2eufB-6fyvA:
31.3		 2eufB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.64A 2hyyB-6fyvA:
22.0		 2hyyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 (-3.9A)
None
None
None
 0.72A 2hyyB-6fyvA:
22.0		 2hyyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.71A 2hyyC-6fyvA:
22.1		 2hyyC-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 10 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
 0.64A 2y7jC-6fyvA:
28.1		 2y7jC-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 10 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
 0.63A 2y7jD-6fyvA:
28.2		 2y7jD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
 0.61A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 3NG  A 501 (-3.9A)
None
None
None
3NG  A 501 (-4.3A)
 0.90A 3cs9A-6fyvA:
21.6		 3cs9A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 244
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
3NG  A 501 (-4.1A)
 1.30A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
None
 0.88A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
LEU A 295
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
None
 0.73A 3cs9B-6fyvA:
21.8		 3cs9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
None
None
None
 0.59A 3cs9C-6fyvA:
21.4		 3cs9C-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 175
LYS A 191
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
 0.87A 3cs9D-6fyvA:
20.5		 3cs9D-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 243
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 ( 4.7A)
 0.60A 3hecA-6fyvA:
25.2		 3hecA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.63A 3ik3A-6fyvA:
21.7		 3ik3A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.62A 3ik3B-6fyvA:
21.5		 3ik3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.60A 3k5vA-6fyvA:
15.9		 3k5vA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 (-3.9A)
None
None
None
 0.68A 3k5vA-6fyvA:
15.9		 3k5vA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.67A 3k5vB-6fyvA:
21.2		 3k5vB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 (-3.9A)
None
None
None
 0.79A 3k5vB-6fyvA:
21.2		 3k5vB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 VAL A 175
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
None
 0.53A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 VAL A 175
VAL A 209
VAL A 225
ILE A 239
 3NG  A 501 ( 4.3A)
None
None
None
 0.67A 3mssD-6fyvA:
21.5		 3mssD-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 209
ILE A 239
LEU A 295
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.78A 3oezB-6fyvA:
22.1		 3oezB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 9 LEU A 167
LYS A 191
VAL A 209
ILE A 239
LEU A 244
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
3NG  A 501 (-4.1A)
 1.08A 3oxzA-6fyvA:
21.5		 3oxzA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 9 LEU A 167
LYS A 191
VAL A 209
ILE A 239
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
None
 0.81A 3oxzA-6fyvA:
21.5		 3oxzA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 209
ILE A 239
LEU A 295
VAL A 323
 3NG  A 501 (-3.9A)
None
None
None
None
 0.83A 3oxzA-6fyvA:
21.5		 3oxzA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 12 LEU A 167
VAL A 175
ALA A 189
GLU A 206
VAL A 225
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
 0.76A 3pyyB-6fyvA:
21.4		 3pyyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 VAL A 175
ALA A 189
GLU A 206
LEU A 210
PHE A 241
LEU A 279
HIS A 286
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 (-3.5A)
None
None
 0.58A 3rgfA-6fyvA:
25.2		 3rgfA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 1.29A 3ue4A-6fyvA:
24.3		 3ue4A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.36A 3ufrA-6fyvA:
undetectable
3ufrB-6fyvA:
undetectable		 3ufrA-6fyvA:
undetectable
3ufrB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.36A 3ufsA-6fyvA:
undetectable
3ufsB-6fyvA:
undetectable		 3ufsA-6fyvA:
undetectable
3ufsB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.61A 3warA-6fyvA:
29.1		 3warA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
 0.57A 3wzeA-6fyvA:
21.9		 3wzeA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 279
HIS A 286
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.79A 3zosA-6fyvA:
20.9		 3zosA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 225
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 1.15A 4ag8A-6fyvA:
21.8		 4ag8A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 1.15A 4agcA-6fyvA:
21.4		 4agcA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.91A 4asdA-6fyvA:
21.7		 4asdA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 279
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
None
 1.05A 4asdA-6fyvA:
21.7		 4asdA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 4c39A-6fyvA:
undetectable
4c39B-6fyvA:
undetectable		 4c39A-6fyvA:
undetectable
4c39B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 4c39A-6fyvA:
undetectable
4c39B-6fyvA:
undetectable		 4c39A-6fyvA:
undetectable
4c39B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 ALA A 189
GLU A 206
LEU A 210
ILE A 239
HIS A 286
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
None
None
3NG  A 501 (-4.3A)
 1.06A 4c8bA-6fyvA:
22.4		 4c8bA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 ALA A 189
LYS A 191
GLU A 206
LEU A 210
ILE A 239
HIS A 286
LEU A 295
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
None
 0.75A 4c8bA-6fyvA:
22.4		 4c8bA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 10 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
SER A 247
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
None
 0.41A 4ckjA-6fyvA:
24.8		 4ckjA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 4ctpA-6fyvA:
undetectable
4ctpB-6fyvA:
undetectable		 4ctpA-6fyvA:
undetectable
4ctpB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.26A 4ctqA-6fyvA:
undetectable
4ctqB-6fyvA:
undetectable		 4ctqA-6fyvA:
undetectable
4ctqB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 4cx6A-6fyvA:
undetectable
4cx6B-6fyvA:
undetectable		 4cx6A-6fyvA:
undetectable
4cx6B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 ASP A 165
ASP A 300
GLU A 177
GLU A 254
 None
 1.15A 4gkhC-6fyvA:
8.6
4gkhK-6fyvA:
8.6		 4gkhC-6fyvA:
undetectable
4gkhK-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 ASP A 165
ASP A 300
GLU A 177
GLU A 254
 None
 1.12A 4gkiE-6fyvA:
8.6
4gkiG-6fyvA:
8.6		 4gkiE-6fyvA:
undetectable
4gkiG-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 11 VAL A 175
ALA A 189
LYS A 191
GLU A 292
LEU A 295
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
3NG  A 501 (-4.3A)
 1.00A 4iaaA-6fyvA:
25.1		 4iaaA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 THR A 381
VAL A 340
SER A 384
ASP A 361
 None
None
SO4  A 502 (-2.7A)
None
 1.23A 4iarA-6fyvA:
2.1		 4iarA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 4jsfA-6fyvA:
undetectable
4jsfB-6fyvA:
undetectable		 4jsfA-6fyvA:
undetectable
4jsfB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 4jsgA-6fyvA:
undetectable
4jsgB-6fyvA:
undetectable		 4jsgA-6fyvA:
undetectable
4jsgB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 4k5gA-6fyvA:
undetectable
4k5gB-6fyvA:
undetectable		 4k5gA-6fyvA:
undetectable
4k5gB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.35A 4luxA-6fyvA:
undetectable
4luxB-6fyvA:
undetectable		 4luxA-6fyvA:
undetectable
4luxB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 11 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASN A 293
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
 0.72A 4o0sA-6fyvA:
26.5		 4o0sA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 6 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
None
 0.51A 4o0wA-6fyvA:
25.6		 4o0wA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
GLY A 170
GLY A 173
VAL A 175
ALA A 189
LYS A 191
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
 0.63A 4otiA-6fyvA:
21.4		 4otiA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 11 SER A 341
LEU A 213
VAL A 209
ASP A 217
ILE A 276
 None
 1.46A 4pghC-6fyvA:
undetectable		 4pghC-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 11 ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.71A 4qmsA-6fyvA:
26.7		 4qmsA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 ALA A 189
LYS A 191
LEU A 210
GLY A 245
HIS A 286
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
None
None
3NG  A 501 (-4.3A)
 1.17A 4u0iA-6fyvA:
22.3		 4u0iA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 4ugzA-6fyvA:
undetectable
4ugzB-6fyvA:
undetectable		 4ugzA-6fyvA:
undetectable
4ugzB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.23A 4uh0A-6fyvA:
undetectable
4uh0B-6fyvA:
undetectable		 4uh0A-6fyvA:
undetectable
4uh0B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 4uh3A-6fyvA:
undetectable
4uh3B-6fyvA:
undetectable		 4uh3A-6fyvA:
undetectable
4uh3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 4uh5A-6fyvA:
undetectable
4uh5B-6fyvA:
undetectable		 4uh5A-6fyvA:
undetectable
4uh5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.30A 4uh6A-6fyvA:
undetectable
4uh6B-6fyvA:
undetectable		 4uh6A-6fyvA:
undetectable
4uh6B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.23A 4uh6A-6fyvA:
undetectable
4uh6B-6fyvA:
undetectable		 4uh6A-6fyvA:
undetectable
4uh6B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 6 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.32A 4v3wA-6fyvA:
0.9
4v3wB-6fyvA:
undetectable		 4v3wA-6fyvA:
undetectable
4v3wB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
ASP A 250
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
 0.52A 4wkqA-6fyvA:
23.7		 4wkqA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
 1.18A 4wkqA-6fyvA:
23.7		 4wkqA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 ALA A 189
LYS A 191
LEU A 210
ASP A 325
PHE A 326
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
3NG  A 501 (-4.3A)
None
 0.92A 4xv2B-6fyvA:
22.3		 4xv2B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		3 / 3 ASP A 312
ARG A 311
TYR A 305
 None
 0.99A 5a7mA-6fyvA:
undetectable		 5a7mA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		3 / 3 ASP A 312
ARG A 311
TYR A 305
 None
 0.96A 5a7mB-6fyvA:
undetectable		 5a7mB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.34A 5ad4A-6fyvA:
undetectable
5ad4B-6fyvA:
undetectable		 5ad4A-6fyvA:
undetectable
5ad4B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.32A 5ad4A-6fyvA:
undetectable
5ad4B-6fyvA:
undetectable		 5ad4A-6fyvA:
undetectable
5ad4B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.26A 5ad5A-6fyvA:
undetectable
5ad5B-6fyvA:
undetectable		 5ad5A-6fyvA:
undetectable
5ad5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.20A 5ad6A-6fyvA:
undetectable
5ad6B-6fyvA:
undetectable		 5ad6A-6fyvA:
undetectable
5ad6B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.26A 5adaA-6fyvA:
undetectable
5adaB-6fyvA:
undetectable		 5adaA-6fyvA:
undetectable
5adaB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 5adaA-6fyvA:
undetectable
5adaB-6fyvA:
undetectable		 5adaA-6fyvA:
undetectable
5adaB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.26A 5adgA-6fyvA:
undetectable
5adgB-6fyvA:
undetectable		 5adgA-6fyvA:
undetectable
5adgB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 5adgA-6fyvA:
undetectable
5adgB-6fyvA:
undetectable		 5adgA-6fyvA:
undetectable
5adgB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.27A 5adiA-6fyvA:
undetectable
5adiB-6fyvA:
undetectable		 5adiA-6fyvA:
undetectable
5adiB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 ILE A 398
PHE A 412
ARG A 346
LEU A 354
 None
None
SO4  A 503 (-2.8A)
None
 0.84A 5b1bN-6fyvA:
1.8
5b1bW-6fyvA:
undetectable		 5b1bN-6fyvA:
undetectable
5b1bW-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 VAL A 175
ALA A 189
LYS A 191
LEU A 210
PHE A 326
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
 0.74A 5cswA-6fyvA:
21.4		 5cswA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 VAL A 175
ALA A 189
LYS A 191
LEU A 210
PHE A 326
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
 0.77A 5cswB-6fyvA:
21.4		 5cswB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.23A 5fvtA-6fyvA:
undetectable
5fvtB-6fyvA:
undetectable		 5fvtA-6fyvA:
undetectable
5fvtB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 5fvuA-6fyvA:
undetectable
5fvuB-6fyvA:
undetectable		 5fvuA-6fyvA:
undetectable
5fvuB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.34A 5fvvA-6fyvA:
undetectable
5fvvB-6fyvA:
undetectable		 5fvvA-6fyvA:
undetectable
5fvvB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 5fvvA-6fyvA:
undetectable
5fvvB-6fyvA:
undetectable		 5fvvA-6fyvA:
undetectable
5fvvB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.27A 5fvwA-6fyvA:
undetectable
5fvwB-6fyvA:
undetectable		 5fvwA-6fyvA:
undetectable
5fvwB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 5fvwA-6fyvA:
undetectable
5fvwB-6fyvA:
undetectable		 5fvwA-6fyvA:
undetectable
5fvwB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.27A 5fvxA-6fyvA:
undetectable
5fvxB-6fyvA:
undetectable		 5fvxA-6fyvA:
undetectable
5fvxB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.20A 5fw0A-6fyvA:
undetectable
5fw0B-6fyvA:
undetectable		 5fw0A-6fyvA:
undetectable
5fw0B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.35A 5g0nA-6fyvA:
undetectable
5g0nB-6fyvA:
undetectable		 5g0nA-6fyvA:
undetectable
5g0nB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 5g0nA-6fyvA:
undetectable
5g0nB-6fyvA:
undetectable		 5g0nA-6fyvA:
undetectable
5g0nB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 12 ALA A 189
LYS A 191
GLU A 206
LEU A 210
LEU A 279
HIS A 286
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.77A 5hi2A-6fyvA:
22.5		 5hi2A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 GLY A 168
GLY A 170
VAL A 175
LYS A 191
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
 0.34A 5izjA-6fyvA:
25.6		 5izjA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 7 GLY A 168
GLY A 170
VAL A 175
LYS A 191
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-4.3A)
 0.68A 5j5xA-6fyvA:
25.6		 5j5xA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		6 / 10 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
 0.67A 5mo4A-6fyvA:
9.7		 5mo4A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 ALA A 189
GLU A 206
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
3NG  A 501 (-4.3A)
 0.62A 5owrA-6fyvA:
22.1		 5owrA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.24A 5untA-6fyvA:
undetectable
5untB-6fyvA:
undetectable		 5untA-6fyvA:
undetectable
5untB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.31A 5unuA-6fyvA:
undetectable
5unuB-6fyvA:
undetectable		 5unuA-6fyvA:
undetectable
5unuB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.23A 5unuA-6fyvA:
undetectable
5unuB-6fyvA:
undetectable		 5unuA-6fyvA:
undetectable
5unuB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.31A 5unwA-6fyvA:
undetectable
5unwB-6fyvA:
undetectable		 5unwA-6fyvA:
undetectable
5unwB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.22A 5unxA-6fyvA:
undetectable
5unxB-6fyvA:
undetectable		 5unxA-6fyvA:
undetectable
5unxB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.33A 5unyA-6fyvA:
undetectable
5unyB-6fyvA:
undetectable		 5unyA-6fyvA:
undetectable
5unyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 5unyA-6fyvA:
undetectable
5unyB-6fyvA:
undetectable		 5unyA-6fyvA:
undetectable
5unyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.32A 5uo1A-6fyvA:
undetectable
5uo1B-6fyvA:
undetectable		 5uo1A-6fyvA:
undetectable
5uo1B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.24A 5uo1A-6fyvA:
undetectable
5uo1B-6fyvA:
undetectable		 5uo1A-6fyvA:
undetectable
5uo1B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.26A 5uo2A-6fyvA:
undetectable
5uo2B-6fyvA:
undetectable		 5uo2A-6fyvA:
undetectable
5uo2B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.24A 5uo3A-6fyvA:
undetectable
5uo3B-6fyvA:
undetectable		 5uo3A-6fyvA:
undetectable
5uo3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.23A 5uo3A-6fyvA:
undetectable
5uo3B-6fyvA:
undetectable		 5uo3A-6fyvA:
undetectable
5uo3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.26A 5uo4A-6fyvA:
undetectable
5uo4B-6fyvA:
undetectable		 5uo4A-6fyvA:
undetectable
5uo4B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.27A 5uo5A-6fyvA:
undetectable
5uo5B-6fyvA:
undetectable		 5uo5A-6fyvA:
undetectable
5uo5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 5uo5A-6fyvA:
undetectable
5uo5B-6fyvA:
undetectable		 5uo5A-6fyvA:
undetectable
5uo5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 5uo6A-6fyvA:
undetectable
5uo6B-6fyvA:
undetectable		 5uo6A-6fyvA:
undetectable
5uo6B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.24A 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable		 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.21A 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable		 5uo7A-6fyvA:
undetectable
5uo7B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		3 / 3 GLU A 421
HIS A 422
ARG A 427
 None
 0.83A 5uunA-6fyvA:
undetectable		 5uunA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
GLY A 245
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
 0.47A 5vcvA-6fyvA:
27.2		 5vcvA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.32A 5vuiA-6fyvA:
undetectable
5vuiB-6fyvA:
undetectable		 5vuiA-6fyvA:
undetectable
5vuiB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.20A 5vuiA-6fyvA:
undetectable
5vuiB-6fyvA:
undetectable		 5vuiA-6fyvA:
undetectable
5vuiB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 5vuvA-6fyvA:
undetectable
5vuvB-6fyvA:
undetectable		 5vuvA-6fyvA:
undetectable
5vuvB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.26A 5vv3A-6fyvA:
undetectable
5vv3B-6fyvA:
undetectable		 5vv3A-6fyvA:
undetectable
5vv3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.26A 5vv4A-6fyvA:
undetectable
5vv4B-6fyvA:
undetectable		 5vv4A-6fyvA:
undetectable
5vv4B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.38A 5vv5A-6fyvA:
undetectable
5vv5B-6fyvA:
undetectable		 5vv5A-6fyvA:
undetectable
5vv5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 5 LEU A 352
TYR A 460
LEU A 388
GLU A 392
 None
 1.33A 5weaA-6fyvA:
undetectable		 5weaA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 GLY A 170
ILE A 239
LYS A 191
ASP A 232
GLY A 235
 3NG  A 501 ( 4.9A)
None
3NG  A 501 (-2.7A)
None
None
 1.12A 5wwsB-6fyvA:
undetectable		 5wwsB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		5 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
PHE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-3.5A)
 0.34A 5xv7A-6fyvA:
36.2		 5xv7A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
 0.93A 5y7zA-6fyvA:
25.2		 5y7zA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		8 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.98A 5y7zB-6fyvA:
16.7		 5y7zB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		9 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.98A 5y80A-6fyvA:
24.1		 5y80A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 LEU A 167
VAL A 175
LYS A 191
PHE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
 0.66A 5y9mX-6fyvA:
28.2		 5y9mX-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.46A 5y9mX-6fyvA:
28.2		 5y9mX-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.66A 5yf9B-6fyvA:
27.9		 5yf9B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.53A 5ywmX-6fyvA:
27.8		 5ywmX-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.30A 6auqA-6fyvA:
undetectable
6auqB-6fyvA:
undetectable		 6auqA-6fyvA:
undetectable
6auqB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.25A 6aurA-6fyvA:
undetectable
6aurB-6fyvA:
undetectable		 6aurA-6fyvA:
undetectable
6aurB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.24A 6aurA-6fyvA:
undetectable
6aurB-6fyvA:
undetectable		 6aurA-6fyvA:
undetectable
6aurB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.24A 6autA-6fyvA:
undetectable
6autB-6fyvA:
undetectable		 6autA-6fyvA:
undetectable
6autB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 6autA-6fyvA:
undetectable
6autB-6fyvA:
undetectable		 6autA-6fyvA:
undetectable
6autB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.24A 6auuA-6fyvA:
undetectable
6auuB-6fyvA:
undetectable		 6auuA-6fyvA:
undetectable
6auuB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.33A 6auvA-6fyvA:
undetectable
6auvB-6fyvA:
undetectable		 6auvA-6fyvA:
undetectable
6auvB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 6auyA-6fyvA:
undetectable
6auyB-6fyvA:
undetectable		 6auyA-6fyvA:
undetectable
6auyB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.28A 6auzA-6fyvA:
undetectable
6auzB-6fyvA:
undetectable		 6auzA-6fyvA:
undetectable
6auzB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 6auzA-6fyvA:
undetectable
6auzB-6fyvA:
undetectable		 6auzA-6fyvA:
undetectable
6auzB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 6av0A-6fyvA:
undetectable
6av0B-6fyvA:
undetectable		 6av0A-6fyvA:
undetectable
6av0B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.29A 6av1A-6fyvA:
undetectable
6av1B-6fyvA:
undetectable		 6av1A-6fyvA:
undetectable
6av1B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.34A 6av1A-6fyvA:
undetectable
6av1B-6fyvA:
undetectable		 6av1A-6fyvA:
undetectable
6av1B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 6av2A-6fyvA:
undetectable
6av2B-6fyvA:
undetectable		 6av2A-6fyvA:
undetectable
6av2B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.28A 6av3A-6fyvA:
undetectable
6av3B-6fyvA:
undetectable		 6av3A-6fyvA:
undetectable
6av3B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.25A 6av4A-6fyvA:
undetectable
6av4B-6fyvA:
undetectable		 6av4A-6fyvA:
undetectable
6av4B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.29A 6av5A-6fyvA:
undetectable
6av5B-6fyvA:
undetectable		 6av5A-6fyvA:
undetectable
6av5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.26A 6av5A-6fyvA:
undetectable
6av5B-6fyvA:
undetectable		 6av5A-6fyvA:
undetectable
6av5B-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.31A 6cicA-6fyvA:
undetectable
6cicB-6fyvA:
undetectable		 6cicA-6fyvA:
undetectable
6cicB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.29A 6cicA-6fyvA:
undetectable
6cicB-6fyvA:
undetectable		 6cicA-6fyvA:
undetectable
6cicB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 MET A 391
VAL A 429
TRP A 419
GLU A 392
 None
 1.27A 6cidA-6fyvA:
undetectable
6cidB-6fyvA:
undetectable		 6cidA-6fyvA:
undetectable
6cidB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens) 		4 / 7 TRP A 419
GLU A 392
MET A 391
VAL A 429
 None
 1.27A 6cidA-6fyvA:
undetectable
6cidB-6fyvA:
undetectable		 6cidA-6fyvA:
undetectable
6cidB-6fyvA:
undetectable