SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6fzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.41A 1fkpA-6fzwA:
undetectable		 1fkpA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.40A 1lwcA-6fzwA:
undetectable		 1lwcA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 5 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.28A 2zlcA-6fzwA:
undetectable		 2zlcA-6fzwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 8 VAL A 242
VAL A 221
GLN A 116
ILE A  69
 None
 0.93A 3hjoA-6fzwA:
undetectable		 3hjoA-6fzwA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.38A 3meeA-6fzwA:
undetectable		 3meeA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.40A 3megA-6fzwA:
undetectable		 3megA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PHE A 235
HIS A 150
GLY A 236
PHE A 107
MET A 111
 None
 1.35A 3v3nD-6fzwA:
undetectable		 3v3nD-6fzwA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 9 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.41A 4puoA-6fzwA:
undetectable		 4puoA-6fzwA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		3 / 3 ALA A  68
TRP A  57
VAL A  58
 None
 0.36A 4w9nC-6fzwA:
undetectable		 4w9nC-6fzwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.36A 5cyqA-6fzwA:
undetectable		 5cyqA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.37A 5hbmA-6fzwA:
undetectable		 5hbmA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 6 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.23A 6ag0A-6fzwA:
undetectable		 6ag0A-6fzwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 6 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.23A 6ag0C-6fzwA:
undetectable		 6ag0C-6fzwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 6fzw COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.38A 6eliA-6fzwA:
undetectable		 6eliA-6fzwA:
22.78