SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 5 VAL A 380
ASN A 381
VAL A 362
ILE A 370
None
0.89A 1z2bC-6g0cA:
undetectable
1z2bC-6g0cA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 11 HIS A 407
THR A 285
ARG A 284
HIS A 277
VAL A 334
None
1.40A 2a5hA-6g0cA:
undetectable
2a5hA-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 HIS A 407
THR A 285
ARG A 284
HIS A 277
VAL A 334
None
1.41A 2a5hB-6g0cA:
undetectable
2a5hB-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 HIS A 407
THR A 285
ARG A 284
HIS A 277
VAL A 334
None
1.41A 2a5hC-6g0cA:
undetectable
2a5hC-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 HIS A 407
THR A 285
ARG A 284
HIS A 277
VAL A 334
None
1.41A 2a5hD-6g0cA:
undetectable
2a5hD-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 5 ASP A 356
LEU A 359
LYS A 360
ARG A 355
None
1.32A 2gj5A-6g0cA:
undetectable
2gj5A-6g0cA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 7 TYR A 246
GLY A 336
ALA A 335
LEU A 252
None
0.92A 2wekB-6g0cA:
undetectable
2wekB-6g0cA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 5 GLN A 275
THR A 285
HIS A 407
LEU A 411
None
1.37A 2zj0A-6g0cA:
undetectable
2zj0A-6g0cA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 326
ALA A 329
ASN A 404
VAL A 293
ILE A 315
None
None
1PS  A1001 (-2.9A)
None
None
1.07A 3e00A-6g0cA:
2.7
3e00A-6g0cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 GLU A 388
ALA A 384
PHE A 333
ALA A 335
ASP A 356
None
1.23A 3nvkF-6g0cA:
undetectable
3nvkJ-6g0cA:
undetectable
3nvkF-6g0cA:
undetectable
3nvkJ-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ALA A 299
GLY A 434
SER A 435
LEU A 306
ALA A 787
None
1.24A 3ou6C-6g0cA:
undetectable
3ou6C-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ALA A 299
GLY A 434
SER A 435
LEU A 306
ALA A 787
None
1.26A 3ou7C-6g0cA:
undetectable
3ou7C-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 3uboB-6g0cA:
undetectable
3uboB-6g0cA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.87A 4e3aA-6g0cA:
undetectable
4e3aA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4e3aB-6g0cA:
undetectable
4e3aB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4jkuB-6g0cA:
undetectable
4jkuB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 8 TYR A 347
VAL A 334
HIS A 277
LEU A 411
None
0.99A 4jtrA-6g0cA:
undetectable
4jtrA-6g0cA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.87A 4k8pA-6g0cA:
undetectable
4k8pA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4k8pB-6g0cA:
undetectable
4k8pB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.89A 4k8tA-6g0cA:
undetectable
4k8tA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.89A 4k8tB-6g0cA:
undetectable
4k8tB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.89A 4k93A-6g0cA:
undetectable
4k93A-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.90A 4k93B-6g0cA:
undetectable
4k93B-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4k9cA-6g0cA:
undetectable
4k9cA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.87A 4k9cB-6g0cA:
undetectable
4k9cB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.90A 4k9iA-6g0cA:
undetectable
4k9iA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.89A 4k9iB-6g0cA:
undetectable
4k9iB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4kadA-6g0cA:
undetectable
4kadA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.88A 4kadB-6g0cA:
undetectable
4kadB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.88A 4lbxA-6g0cA:
undetectable
4lbxA-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.88A 4lbxB-6g0cA:
undetectable
4lbxB-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.86A 4lc4A-6g0cA:
undetectable
4lc4A-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 779
ASP A 780
GLY A 777
LEU A 880
GLU A 772
None
0.87A 4lc4B-6g0cA:
undetectable
4lc4B-6g0cA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ILE A 403
GLN A 330
ALA A 335
ILE A 328
PHE A 332
None
1.48A 4rp9A-6g0cA:
undetectable
4rp9A-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
5 / 12 ALA A 296
PHE A 232
ALA A 242
ALA A 244
THR A 282
None
EDO  A1004 (-4.8A)
None
None
None
1.34A 6aycA-6g0cA:
undetectable
6aycA-6g0cA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 6 PHE A 448
LEU A 568
LEU A 571
HIS A 575
None
0.79A 6e43A-6g0cA:
undetectable
6e43A-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 6 PHE A 448
LEU A 568
LEU A 571
HIS A 575
None
0.75A 6e43B-6g0cA:
undetectable
6e43B-6g0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
6g0c UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA

(Legionella
pneumophila)
4 / 6 PHE A 448
LEU A 568
LEU A 571
HIS A 575
None
0.73A 6e43D-6g0cA:
undetectable
6e43D-6g0cA:
undetectable