SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		5 / 9 LEU A  74
ILE A  78
VAL A 112
GLY A 110
ALA A 103
 None
 1.11A 1e7aA-6g1kA:
3.6		 1e7aA-6g1kA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 8 LEU A 525
PHE A 530
GLY A 533
TYR A 523
 None
 1.06A 1fapB-6g1kA:
1.4		 1fapB-6g1kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		5 / 12 THR A 375
PRO A 341
ILE A 406
VAL A 402
LEU A 382
 None
 1.20A 1z9hD-6g1kA:
undetectable		 1z9hD-6g1kA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		3 / 3 PHE A 251
SER A 213
LEU A 211
 None
 0.83A 2w1bA-6g1kA:
undetectable		 2w1bA-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 5 THR A 567
PHE A 561
PHE A 601
TYR A 604
 None
 1.30A 3em0A-6g1kA:
undetectable		 3em0A-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		5 / 12 PHE A 366
PHE A 637
ALA A 498
THR A 497
ILE A 507
 None
None
Y01  A1001 (-3.8A)
None
None
 1.25A 3ndiA-6g1kA:
undetectable		 3ndiA-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		5 / 12 PHE A 366
PHE A 637
ALA A 498
THR A 497
ILE A 507
 None
None
Y01  A1001 (-3.8A)
None
None
 1.37A 3ndiA-6g1kA:
undetectable		 3ndiA-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 7 ALA A 210
LEU A 208
SER A 205
VAL A 717
 None
 0.64A 3ozkB-6g1kA:
undetectable		 3ozkB-6g1kA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U01_A_ACTA108_0
(PROTEIN P-30)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 4 ARG A 354
TYR A 355
SER A 353
LYS A 352
 None
 1.47A 3u01A-6g1kA:
undetectable		 3u01A-6g1kA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 5 THR A 563
GLN A 569
GLU A 566
THR A 567
 None
44E  A1002 (-3.2A)
None
None
 1.30A 4eahA-6g1kA:
3.5
4eahE-6g1kA:
3.5
4eahG-6g1kA:
undetectable		 4eahA-6g1kA:
undetectable
4eahE-6g1kA:
undetectable
4eahG-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		3 / 3 TYR A 705
PHE A 300
ARG A 288
 None
 1.17A 4g19D-6g1kA:
undetectable		 4g19D-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 8 ALA A 210
LEU A 208
SER A 205
VAL A 717
 None
 0.70A 4ik7B-6g1kA:
undetectable		 4ik7B-6g1kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 4 ILE A 158
ASN A 154
ILE A 721
VAL A 717
 None
 1.25A 4uy87-6g1kA:
undetectable		 4uy87-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 6 ALA A 210
LEU A 208
SER A 205
VAL A 717
 None
 0.83A 5a6iA-6g1kA:
undetectable		 5a6iA-6g1kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 5 ALA A 103
ALA A 111
ILE A  78
LEU A  74
 None
 0.81A 5jncD-6g1kA:
undetectable		 5jncD-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 9 ILE A 406
TYR A 445
ILE A 449
ILE A 453
 None
 0.63A 5vkqB-6g1kA:
21.4
5vkqC-6g1kA:
21.4		 5vkqB-6g1kA:
undetectable
5vkqC-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		5 / 12 THR A 152
LEU A 148
VAL A 112
ILE A  78
GLU A 107
 None
 1.41A 5w8aA-6g1kA:
undetectable		 5w8aA-6g1kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A
(Danio
rerio) 		4 / 7 ARG A 296
ALA A 302
GLN A 307
GLN A 228
 None
 0.83A 6b89A-6g1kA:
undetectable		 6b89A-6g1kA:
18.60