SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 434
LEU A 370
VAL A 425
ALA A 414
ALA A 415
 None
 1.06A 1n5xA-6g3dA:
undetectable		 1n5xA-6g3dA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 434
LEU A 370
VAL A 425
ALA A 414
ALA A 415
 None
 1.06A 1n5xB-6g3dA:
undetectable		 1n5xB-6g3dA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 THR A 419
LEU A 410
VAL A 411
ILE A 406
ALA A 385
 None
 1.06A 2zbzA-6g3dA:
undetectable		 2zbzA-6g3dA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 ALA A 256
ALA A 270
TYR A 267
MET A 154
 None
 1.27A 3d91A-6g3dA:
undetectable		 3d91A-6g3dA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		4 / 8 ILE A 316
GLU A 230
ALA A 323
GLU A 326
 None
 0.73A 4jltA-6g3dA:
undetectable		 4jltA-6g3dA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		4 / 7 LEU A 128
ARG A 185
SER A 331
VAL A 247
 None
 1.27A 4klrA-6g3dA:
undetectable		 4klrA-6g3dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 249
LEU A 252
LEU A 255
ALA A 256
LEU A  25
 None
 1.01A 4ltwA-6g3dA:
undetectable		 4ltwA-6g3dA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A 232
ALA A 233
TYR A 320
SER A 321
ASP A 114
 None
 1.13A 4mm8A-6g3dA:
undetectable		 4mm8A-6g3dA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 ILE A 175
LEU A 172
GLU A 258
VAL A 269
 None
 1.01A 4nkxB-6g3dA:
undetectable		 4nkxB-6g3dA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		3 / 3 PRO A 197
LEU A 198
HIS A 107
 None
 0.60A 4pevA-6g3dA:
undetectable		 4pevA-6g3dA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.91A 4rrwA-6g3dA:
undetectable		 4rrwA-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.93A 4rrwB-6g3dA:
undetectable		 4rrwB-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.90A 4rrwC-6g3dA:
undetectable		 4rrwC-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.91A 4rrzA-6g3dA:
undetectable		 4rrzA-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.93A 4rrzB-6g3dA:
undetectable		 4rrzB-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 VAL A  51
LEU A  60
SER A  65
VAL A 102
GLY A 104
 None
 0.90A 4rrzC-6g3dA:
undetectable		 4rrzC-6g3dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 ALA A 200
ALA A 118
ARG A 121
LEU A 198
HIS A 107
 None
 1.47A 4zo1X-6g3dA:
undetectable		 4zo1X-6g3dA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6g3d ARGININOSUCCINATE
LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 LEU A 335
ASN A 245
ILE A 336
THR A 339
HIS A 340
 None
 1.25A 6d9hR-6g3dA:
3.1		 6d9hR-6g3dA:
19.54