SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 6g3u -
(-) 		4 / 6 PHE A 111
ILE A  49
LYS A 129
ALA A 128
 None
 1.26A 1hk2A-6g3uA:
undetectable		 1hk2A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 6g3u -
(-) 		5 / 12 HIS A 269
GLY A 268
ARG A 326
LEU A 240
GLU A 237
 None
 1.05A 1mj2A-6g3uA:
undetectable
1mj2B-6g3uA:
undetectable		 1mj2A-6g3uA:
undetectable
1mj2B-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 6g3u -
(-) 		5 / 12 HIS A 269
GLY A 268
ARG A 326
LEU A 240
GLU A 237
 None
 1.05A 1mj2C-6g3uA:
undetectable
1mj2D-6g3uA:
undetectable		 1mj2C-6g3uA:
undetectable
1mj2D-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 6g3u -
(-) 		5 / 12 HIS A 269
GLY A 268
ARG A 326
LEU A 240
GLU A 237
 None
 1.12A 1mjqC-6g3uA:
undetectable
1mjqD-6g3uA:
undetectable		 1mjqC-6g3uA:
undetectable
1mjqD-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 6g3u -
(-) 		5 / 12 HIS A 269
GLY A 268
ARG A 326
LEU A 240
GLU A 237
 None
 1.12A 1mjqI-6g3uA:
undetectable
1mjqJ-6g3uA:
undetectable		 1mjqI-6g3uA:
undetectable
1mjqJ-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 6g3u -
(-) 		4 / 8 TYR A 598
PHE A 607
HIS A 660
GLY A 658
 None
 1.15A 2ha4A-6g3uA:
undetectable		 2ha4A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6g3u -
(-) 		4 / 7 VAL A  91
LYS A  95
SER A 299
LYS A 303
 None
 1.49A 2j9cA-6g3uA:
undetectable
2j9cB-6g3uA:
undetectable
2j9cC-6g3uA:
undetectable		 2j9cA-6g3uA:
undetectable
2j9cB-6g3uA:
undetectable
2j9cC-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6g3u -
(-) 		5 / 10 ILE A 698
ALA A 690
LEU A 687
ILE A  26
PHE A 733
 None
 1.15A 2w9sC-6g3uA:
2.4		 2w9sC-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6g3u -
(-) 		4 / 7 TYR A   9
ALA A 609
THR A 637
LEU A 663
 None
 0.95A 2wx2A-6g3uA:
undetectable		 2wx2A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 6g3u -
(-) 		4 / 6 ARG A 124
PRO A 137
GLY A 132
MET A 258
 None
 1.30A 3aqiA-6g3uA:
3.1		 3aqiA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 6g3u -
(-) 		4 / 6 ARG A 124
PRO A 137
GLY A 132
MET A 258
 None
 1.31A 3aqiB-6g3uA:
undetectable		 3aqiB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6g3u -
(-) 		5 / 12 ALA A  31
GLY A  35
HIS A 683
SER A   5
LEU A  24
 None
 1.32A 3bxoA-6g3uA:
undetectable		 3bxoA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 6g3u -
(-) 		3 / 3 ASP A  66
ARG A  69
ARG A 717
 None
 0.81A 3k37A-6g3uA:
undetectable		 3k37A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 6g3u -
(-) 		4 / 8 TYR A   9
ALA A 609
THR A 637
LEU A 663
 None
 0.89A 3khmA-6g3uA:
undetectable		 3khmA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 6g3u -
(-) 		3 / 3 ASN A 391
ASN A 396
GLU A 530
 None
 0.83A 3kpdC-6g3uA:
undetectable		 3kpdC-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 6g3u -
(-) 		3 / 3 ASN A 391
ASN A 396
GLU A 530
 None
 0.85A 3kpdB-6g3uA:
undetectable		 3kpdB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6g3u -
(-) 		5 / 11 TYR A 127
ILE A  98
GLY A  96
ALA A  97
LEU A  45
 None
 1.19A 3n8yA-6g3uA:
undetectable		 3n8yA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6g3u -
(-) 		5 / 12 SER A 613
LEU A  24
ILE A   7
ALA A  31
ALA A 632
 None
 1.02A 3nxuA-6g3uA:
undetectable		 3nxuA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 6g3u -
(-) 		5 / 12 SER A 613
LEU A  24
ILE A   7
ALA A  31
ALA A 632
 None
 1.04A 3nxuB-6g3uA:
undetectable		 3nxuB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6g3u -
(-) 		4 / 7 GLU A 615
ILE A 619
GLU A 616
VAL A 410
 None
 1.06A 4a97A-6g3uA:
undetectable		 4a97A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6g3u -
(-) 		4 / 7 GLU A 615
ILE A 619
GLU A 616
VAL A 410
 None
 1.06A 4a97D-6g3uA:
undetectable		 4a97D-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6g3u -
(-) 		4 / 7 GLU A 615
ILE A 619
GLU A 616
VAL A 410
 None
 1.08A 4a97H-6g3uA:
undetectable		 4a97H-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 6g3u -
(-) 		4 / 8 VAL A 541
TYR A 521
ILE A 539
ILE A 485
 None
 0.98A 4afgD-6g3uA:
undetectable
4afgE-6g3uA:
undetectable		 4afgD-6g3uA:
undetectable
4afgE-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6g3u -
(-) 		3 / 3 TYR A 382
HIS A 494
ARG A 492
 None
 1.13A 4htfA-6g3uA:
undetectable		 4htfA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 6g3u -
(-) 		5 / 12 PRO A 115
ALA A 125
ILE A 265
HIS A 269
GLY A 453
 None
 1.06A 4l9qA-6g3uA:
3.2		 4l9qA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 6g3u -
(-) 		5 / 12 VAL A 152
LEU A 532
SER A 406
ALA A 148
MET A 565
 None
 1.32A 4qdcA-6g3uA:
undetectable		 4qdcA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 6g3u -
(-) 		5 / 11 SER A  88
ALA A 586
PRO A 587
THR A  12
ILE A  43
 AKG  A 802 ( 3.0A)
NAP  A 801 (-4.2A)
NAP  A 801 (-4.3A)
None
None
 1.31A 4uuuB-6g3uA:
undetectable		 4uuuB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 6g3u -
(-) 		4 / 7 SER A 603
PHE A 607
TRP A 667
TYR A   9
 None
 1.46A 5dlvB-6g3uA:
undetectable		 5dlvB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 6g3u -
(-) 		5 / 12 GLU A 606
GLY A 605
LEU A 566
SER A 567
VAL A 152
 None
 1.01A 5dpdA-6g3uA:
undetectable		 5dpdA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6g3u -
(-) 		5 / 12 ASP A  13
ASP A 548
GLY A 583
SER A 562
SER A 585
 None
AKG  A 802 (-3.7A)
NAP  A 801 (-4.1A)
None
NAP  A 801 (-3.4A)
 1.12A 5hfjD-6g3uA:
undetectable		 5hfjD-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6g3u -
(-) 		5 / 12 ASP A  13
ASP A 548
GLY A 583
SER A 562
SER A 585
 None
AKG  A 802 (-3.7A)
NAP  A 801 (-4.1A)
None
NAP  A 801 (-3.4A)
 1.09A 5hfjE-6g3uA:
undetectable		 5hfjE-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6g3u -
(-) 		4 / 6 LYS A 153
ARG A 157
ASP A 537
GLY A 535
 None
 1.32A 5hp1A-6g3uA:
undetectable		 5hp1A-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6g3u -
(-) 		5 / 10 ALA A 524
SER A 528
THR A 381
GLY A 543
LEU A 546
 None
 1.25A 5m5cE-6g3uA:
undetectable		 5m5cE-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6g3u -
(-) 		4 / 7 HIS A 253
LEU A 252
VAL A 349
SER A 352
 None
 1.05A 5m8rA-6g3uA:
undetectable		 5m8rA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 6g3u -
(-) 		5 / 9 LEU A 546
VAL A 545
LEU A 498
HIS A 494
THR A 381
 None
 1.46A 5mxbA-6g3uA:
undetectable		 5mxbA-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6g3u -
(-) 		4 / 6 ASP A 655
GLY A 658
PHE A 661
TYR A 598
 None
 0.77A 5nooC-6g3uA:
undetectable		 5nooC-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 6g3u -
(-) 		5 / 12 ALA A  68
GLU A 141
LEU A  73
ILE A  81
VAL A 135
 None
 1.27A 5vlmB-6g3uA:
undetectable		 5vlmB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6g3u -
(-) 		5 / 12 GLU A 695
ASP A 655
GLY A 658
PHE A 661
TYR A 598
 None
 1.18A 5x5qB-6g3uA:
undetectable		 5x5qB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6g3u -
(-) 		5 / 12 ILE A 698
ASP A 655
GLY A 658
PHE A 661
MET A 727
 None
 0.93A 5x5qB-6g3uA:
undetectable		 5x5qB-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6g3u -
(-) 		5 / 11 PRO A 344
PRO A  92
LEU A 131
LEU A  45
ASP A  13
 None
 1.41A 6dlzA-6g3uA:
undetectable
6dlzD-6g3uA:
2.8		 6dlzA-6g3uA:
undetectable
6dlzD-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6g3u -
(-) 		5 / 11 PRO A 344
PRO A  92
LEU A 131
LEU A  45
ASP A  13
 None
 1.42A 6dm1A-6g3uA:
undetectable
6dm1D-6g3uA:
2.1		 6dm1A-6g3uA:
undetectable
6dm1D-6g3uA:
undetectable