SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU B 243
PHE B 169
MET B 260
ILE B 214
SER B  70
 None
 1.22A 3aqiB-6g4qB:
undetectable		 3aqiB-6g4qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE B 427
LEU B 419
ALA B 418
ILE B 387
LEU B 408
 None
 1.07A 3dauA-6g4qB:
undetectable		 3dauA-6g4qB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN B 258
GLU B 193
ILE B 192
ASP B 194
 None
 1.13A 4d33B-6g4qB:
undetectable		 4d33B-6g4qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN B 258
GLU B 193
ILE B 192
ASP B 194
 None
 1.11A 4d39B-6g4qB:
undetectable		 4d39B-6g4qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL B  71
MET B  61
GLU B  62
LEU B 156
 EDO  B 501 (-4.8A)
None
None
None
 1.47A 4hojA-6g4qB:
undetectable		 4hojA-6g4qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU B  90
ASP B  94
ARG B 160
ILE B 121
 None
 1.24A 4mwrA-6g4qB:
undetectable		 4mwrA-6g4qB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS B 242
ASN B 239
SER B  70
 None
 1.11A 5yw0A-6g4qB:
undetectable		 5yw0A-6g4qB:
undetectable