SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_D_TRPD81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6g5i	RNA-BINDING PROTEIN PNO1 (Homo sapiens)	4 / 7	VAL x 209 THR x 198 THR x 200 ILE x 202	None	0.85A	1gtnC-6g5ix: undetectable 1gtnD-6g5ix: undetectable	1gtnC-6g5ix: undetectable 1gtnD-6g5ix: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C6N_B_LPRB705_2 (ANGIOTENSIN-CONVERTI NG ENZYME, SOMATIC ISOFORM)	6g5i	RNA-BINDING PROTEIN PNO1 (Homo sapiens)	3 / 3	ALA x 221 THR x 200 PHE x 163	None	0.77A	2c6nB-6g5ix: undetectable	2c6nB-6g5ix: 9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA502_0 (RNA POLYMERASE 3D-POL)	6g5i	SERINE/THREONINE-PRO TEIN KINASE RIO1 (Homo sapiens)	3 / 3	ARG z 534 LYS z 535 LYS z 531	None G 21043 ( 2.7A) G 21044 ( 4.1A)	1.08A	4k50A-6g5iz: undetectable	4k50A-6g5iz: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	6g5i	SERINE/THREONINE-PRO TEIN KINASE RIO1 (Homo sapiens)	3 / 3	ARG z 534 LYS z 535 LYS z 531	None G 21043 ( 2.7A) G 21044 ( 4.1A)	0.95A	4k50E-6g5iz: undetectable	4k50E-6g5iz: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI506_0 (RNA POLYMERASE 3D-POL)	6g5i	SERINE/THREONINE-PRO TEIN KINASE RIO1 (Homo sapiens)	3 / 3	ARG z 534 LYS z 535 LYS z 531	None G 21043 ( 2.7A) G 21044 ( 4.1A)	1.02A	4k50I-6g5iz: undetectable	4k50I-6g5iz: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODO_B_FK5B203_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD)	6g5i	RNA-BINDING PROTEIN PNO1 (Homo sapiens)	5 / 10	ASP x 135 LEU x 130 LEU x 105 ILE x 99 LEU x 103	None	1.00A	4odoB-6g5ix: undetectable	4odoB-6g5ix: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODO_C_FK5C204_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD)	6g5i	RNA-BINDING PROTEIN PNO1 (Homo sapiens)	5 / 10	ASP x 135 LEU x 130 LEU x 105 ILE x 99 LEU x 103	None	0.97A	4odoC-6g5ix: undetectable	4odoC-6g5ix: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y9Y_A_ACTA409_0 (UNCHARACTERIZED PROTEIN KDOO)	6g5i	RNA-BINDING PROTEIN PNO1 (Homo sapiens)	3 / 3	LYS x 169 PRO x 170 LYS x 172	U 21839 ( 4.9A) None G 21858 ( 4.1A)	1.03A	5y9yA-6g5ix: undetectable	5y9yA-6g5ix: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTN_D_TRPD81_0","TRP RNA-BINDING ATTENUATION PROTEIN","6g5i","RNA-BINDING PROTEIN PNO1","Homo sapiens",4,"VAL x 209;THR x 198;THR x 200;ILE x 202","None","0.85A","1gtnC-6g5ix:undetectable;1gtnD-6g5ix:undetectable","1gtnC-6g5ix:undetectable;1gtnD-6g5ix:undetectable"],["2C6N_B_LPRB705_2","ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM","6g5i","RNA-BINDING PROTEIN PNO1","Homo sapiens",3,"ALA x 221;THR x 200;PHE x 163","None","0.77A","2c6nB-6g5ix:undetectable","2c6nB-6g5ix:9.36"],["4K50_A_ACTA502_0","RNA POLYMERASE 3D-POL","6g5i","SERINE\/THREONINE-PROTEIN KINASE RIO1","Homo sapiens",3,"ARG z 534;LYS z 535;LYS z 531","None;  G 21043 ( 2.7A);  G 21044 ( 4.1A)","1.08A","4k50A-6g5iz:undetectable","4k50A-6g5iz:undetectable"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","6g5i","SERINE\/THREONINE-PROTEIN KINASE RIO1","Homo sapiens",3,"ARG z 534;LYS z 535;LYS z 531","None;  G 21043 ( 2.7A);  G 21044 ( 4.1A)","0.95A","4k50E-6g5iz:undetectable","4k50E-6g5iz:undetectable"],["4K50_I_ACTI506_0","RNA POLYMERASE 3D-POL","6g5i","SERINE\/THREONINE-PROTEIN KINASE RIO1","Homo sapiens",3,"ARG z 534;LYS z 535;LYS z 531","None;  G 21043 ( 2.7A);  G 21044 ( 4.1A)","1.02A","4k50I-6g5iz:undetectable","4k50I-6g5iz:undetectable"],["4ODO_B_FK5B203_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD","6g5i","RNA-BINDING PROTEIN PNO1","Homo sapiens",5,"ASP x 135;LEU x 130;LEU x 105;ILE x  99;LEU x 103","None","1.00A","4odoB-6g5ix:undetectable","4odoB-6g5ix:19.87"],["4ODO_C_FK5C204_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD","6g5i","RNA-BINDING PROTEIN PNO1","Homo sapiens",5,"ASP x 135;LEU x 130;LEU x 105;ILE x  99;LEU x 103","None","0.97A","4odoC-6g5ix:undetectable","4odoC-6g5ix:19.87"],["5Y9Y_A_ACTA409_0","UNCHARACTERIZED PROTEIN KDOO","6g5i","RNA-BINDING PROTEIN PNO1","Homo sapiens",3,"LYS x 169;PRO x 170;LYS x 172","  U 21839 ( 4.9A);None;  G 21858 ( 4.1A)","1.03A","5y9yA-6g5ix:undetectable","5y9yA-6g5ix:undetectable"]]