SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		5 / 11 ALA A1042
ILE A1013
ILE A1016
LEU A1028
ILE A1045
 None
 1.03A 3clbA-6g6sA:
undetectable		 3clbA-6g6sA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		5 / 10 ALA A1042
ILE A1013
ILE A1016
LEU A1028
ILE A1045
 None
 1.03A 3hbbA-6g6sA:
undetectable		 3hbbA-6g6sA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		5 / 9 LEU A1092
HIS A1015
GLU A1091
HIS A1051
ILE A1045
 None
 1.23A 3hy7A-6g6sA:
undetectable		 3hy7A-6g6sA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		5 / 9 LEU A1092
HIS A1015
GLU A1091
HIS A1051
ILE A1045
 None
 1.23A 3hy7B-6g6sA:
undetectable		 3hy7B-6g6sA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		3 / 3 TYR A1056
THR A1035
GLU A1040
 None
 0.71A 4df3A-6g6sA:
undetectable		 4df3A-6g6sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6g6s APOPTOTIC CHROMATIN
CONDENSATION INDUCER
IN THE NUCLEUS
(Homo
sapiens) 		3 / 3 TYR A1056
THR A1035
GLU A1040
 None
 0.74A 4df3B-6g6sA:
undetectable		 4df3B-6g6sA:
undetectable