SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		4 / 6 PHE A 225
GLU A 214
ARG A 244
ILE A 216
 None
 1.49A 1nsiC-6g74A:
undetectable
1nsiD-6g74A:
undetectable		 1nsiC-6g74A:
11.24
1nsiD-6g74A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 GLU A 195
HIS A 171
HIS A 193
 PHT  A 302 ( 3.6A)
None
PHT  A 302 (-3.8A)
 0.68A 1oe2A-6g74A:
undetectable		 1oe2A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 12 VAL A 276
ILE A 283
LEU A 278
ILE A  65
ALA A  43
 None
 1.24A 2gj5A-6g74A:
undetectable		 2gj5A-6g74A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 HIS A  19
MET A  59
MET A 257
 PHT  A 302 (-4.0A)
PHT  A 302 ( 4.9A)
None
 1.30A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 HIS A  19
MET A 257
MET A  59
 PHT  A 302 (-4.0A)
None
PHT  A 302 ( 4.9A)
 1.40A 2vj1A-6g74A:
undetectable		 2vj1A-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 GLU A 218
GLN A  38
ARG A  41
 None
 0.94A 2w3bB-6g74A:
undetectable		 2w3bB-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 11 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.18A 4pxmB-6g74A:
undetectable		 4pxmB-6g74A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 10 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.17A 5dx3A-6g74A:
undetectable		 5dx3A-6g74A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 11 MET A  59
LEU A  66
ALA A  43
GLY A  34
HIS A  19
 PHT  A 302 ( 4.9A)
None
None
None
PHT  A 302 (-4.0A)
 1.19A 5dxgB-6g74A:
undetectable		 5dxgB-6g74A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		3 / 3 MET A 257
HIS A  19
GLY A 232
 None
PHT  A 302 (-4.0A)
None
 0.86A 5gwzB-6g74A:
undetectable		 5gwzB-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 10 LYS A 288
ILE A 290
ILE A 121
LEU A 106
ILE A 283
 None
 1.05A 5vkqA-6g74A:
undetectable
5vkqD-6g74A:
undetectable		 5vkqA-6g74A:
undetectable
5vkqD-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 10 ILE A 283
LYS A 288
ILE A 290
ILE A 121
LEU A 106
 None
 1.09A 5vkqA-6g74A:
undetectable
5vkqB-6g74A:
undetectable		 5vkqA-6g74A:
undetectable
5vkqB-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 10 ILE A 283
LYS A 288
ILE A 290
ILE A 121
LEU A 106
 None
 1.05A 5vkqC-6g74A:
undetectable
5vkqD-6g74A:
undetectable		 5vkqC-6g74A:
undetectable
5vkqD-6g74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 6g74 QUINOLINATE SYNTHASE
A
(Thermotoga
maritima) 		5 / 12 HIS A 193
ASN A  20
GLY A  34
HIS A  19
MET A  59
 PHT  A 302 (-3.8A)
None
None
PHT  A 302 (-4.0A)
PHT  A 302 ( 4.9A)
 1.28A 6exiD-6g74A:
undetectable		 6exiD-6g74A:
24.18