SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 6g8r SHORT-CHAIN VARIABLE
FRAGMENT
(Homo
sapiens) 		6 / 12 TYR A 170
GLN A 223
PHE A 231
VAL A  37
ALA A  97
TRP A 109
 None
 0.68A 1h8sA-6g8rA:
21.1		 1h8sA-6g8rA:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens) 		4 / 7 LEU B 766
ILE B 731
ARG B 734
TYR B 771
 None
 0.97A 2hc4A-6g8rB:
undetectable		 2hc4A-6g8rB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens) 		5 / 9 ILE B 826
ILE B 804
LYS B 803
GLU B 797
TYR B 785
 None
 1.37A 3f78A-6g8rB:
undetectable		 3f78A-6g8rB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens) 		5 / 9 ILE B 826
ILE B 804
LYS B 803
GLU B 797
TYR B 785
 None
 1.37A 3f78B-6g8rB:
undetectable		 3f78B-6g8rB:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6g8r SHORT-CHAIN VARIABLE
FRAGMENT
(Homo
sapiens) 		5 / 12 VAL A   2
ALA A  24
MET A  34
ARG A  72
TYR A 108
 None
 0.99A 3qxvB-6g8rA:
20.2		 3qxvB-6g8rA:
62.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 6g8r SHORT-CHAIN VARIABLE
FRAGMENT
(Homo
sapiens) 		4 / 5 ARG A  98
LEU A   4
VAL A   2
ASP A 107
 None
 1.13A 3ufnA-6g8rA:
undetectable
3ufnB-6g8rA:
undetectable		 3ufnA-6g8rA:
22.55
3ufnB-6g8rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6g8r NUCLEAR BODY PROTEIN
SP140
SHORT-CHAIN VARIABLE
FRAGMENT
(Homo
sapiens) 		4 / 5 TYR B 786
LEU A 114
PRO A  41
LEU A  86
 None
 1.44A 5eshA-6g8rB:
undetectable		 5eshA-6g8rB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens) 		4 / 6 VAL B 857
ARG B 824
ILE B 826
PHE B 827
 None
 0.96A 5jw1A-6g8rB:
undetectable		 5jw1A-6g8rB:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens) 		4 / 6 VAL B 857
ARG B 824
ILE B 826
PHE B 827
 None
 1.01A 5jw1B-6g8rB:
undetectable		 5jw1B-6g8rB:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 6g8r SHORT-CHAIN VARIABLE
FRAGMENT
(Homo
sapiens) 		4 / 8 THR A 208
SER A 197
THR A 206
SER A 199
 None
 0.98A 5l4eA-6g8rA:
2.2
5l4eB-6g8rA:
undetectable
5l4eC-6g8rA:
undetectable
5l4eD-6g8rA:
undetectable
5l4eE-6g8rA:
undetectable		 5l4eA-6g8rA:
16.39
5l4eB-6g8rA:
16.39
5l4eC-6g8rA:
16.39
5l4eD-6g8rA:
16.39
5l4eE-6g8rA:
16.39