SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6g9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 581
LEU A 558
VAL A 583
SER A 586
LEU A 621
 None
 1.03A 1db1A-6g9oA:
undetectable		 1db1A-6g9oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 ARG A 262
ASP A 371
ARG A 148
ASP A 258
 None
 1.11A 2e5dA-6g9oA:
undetectable
2e5dB-6g9oA:
undetectable		 2e5dA-6g9oA:
undetectable
2e5dB-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 ASP A 258
ARG A 262
ASP A 371
ARG A 148
 None
 1.13A 2e5dA-6g9oA:
undetectable
2e5dB-6g9oA:
undetectable		 2e5dA-6g9oA:
undetectable
2e5dB-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 448
GLY A 470
LEU A 468
ILE A 465
LEU A 474
 None
 0.98A 2f8dA-6g9oA:
undetectable		 2f8dA-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 10 LEU A 448
GLY A 470
LEU A 468
ILE A 465
LEU A 474
 None
 0.96A 2f8dB-6g9oA:
undetectable		 2f8dB-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.21A 2po7B-6g9oA:
undetectable		 2po7B-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 PHE A 390
SER A 158
HIS A 155
LEU A 153
MET A 375
 None
 1.34A 2prgA-6g9oA:
undetectable		 2prgA-6g9oA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 4 LEU A 435
PRO A 439
LEU A 432
ARG A 419
 None
 1.43A 2qd2A-6g9oA:
undetectable		 2qd2A-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 SER A 140
CYH A 139
ILE A 135
SER A  32
 None
 1.04A 2xz5A-6g9oA:
undetectable
2xz5B-6g9oA:
undetectable		 2xz5A-6g9oA:
undetectable
2xz5B-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 SER A 140
CYH A 139
ILE A 135
SER A  32
 None
 1.07A 2xz5B-6g9oA:
undetectable
2xz5E-6g9oA:
undetectable		 2xz5B-6g9oA:
undetectable
2xz5E-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 GLY A 525
SER A 528
ILE A 508
ARG A 550
LEU A 523
 None
 1.15A 3iv6C-6g9oA:
undetectable		 3iv6C-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 GLY A 525
SER A 528
ILE A 508
ARG A 550
LEU A 523
 None
 1.24A 3iv6D-6g9oA:
undetectable		 3iv6D-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 ARG A 600
ASP A 620
ASP A 623
 None
 0.88A 3jb3A-6g9oA:
undetectable		 3jb3A-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 9 LEU A 669
ILE A 606
PRO A 655
ILE A 654
ILE A 651
 None
 0.97A 3s56B-6g9oA:
undetectable		 3s56B-6g9oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 7 VAL A 536
ILE A 537
LEU A 518
LEU A 543
 None
 0.75A 4l1wA-6g9oA:
undetectable		 4l1wA-6g9oA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 5 ILE A 619
LEU A 616
GLU A 597
VAL A 548
 None
 0.98A 4nkxB-6g9oA:
undetectable		 4nkxB-6g9oA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		5 / 12 VAL A 442
LEU A 474
LEU A 476
ILE A 456
VAL A 459
 None
 0.80A 4y0rA-6g9oA:
undetectable		 4y0rA-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 6 ILE A 500
HIS A 431
ILE A 456
VAL A 459
 None
 0.92A 4zj8A-6g9oA:
3.4		 4zj8A-6g9oA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 4 LEU A 596
ILE A 619
PRO A 607
LEU A 603
 None
 1.10A 5eb3A-6g9oA:
undetectable		 5eb3A-6g9oA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 MET A 590
LEU A 551
ILE A 574
LEU A 518
 None
 1.03A 5ieoA-6g9oA:
undetectable		 5ieoA-6g9oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 ARG A 345
TRP A 342
TRP A  24
THR A 268
 None
 1.49A 5l8dA-6g9oA:
undetectable		 5l8dA-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 8 ARG A 345
TRP A 342
TRP A  24
THR A 268
 None
 1.49A 5mwuA-6g9oA:
undetectable		 5mwuA-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 THR A 716
HIS A 694
ASN A 670
 None
 0.88A 5n4tA-6g9oA:
undetectable		 5n4tA-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		3 / 3 HIS A 104
ASN A 107
ALA A 111
 None
 0.40A 5n4tB-6g9oA:
undetectable		 5n4tB-6g9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A
(Mus
musculus) 		4 / 5 ASN A 576
TYR A 534
VAL A 561
LEU A 540
 None
 1.27A 6a7pA-6g9oA:
4.3		 6a7pA-6g9oA:
undetectable