SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gbc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
GLY A 266
GLY A 267
ASN A 325
PHE A 333
 MG  A 502 ( 4.3A)
AMP  A 501 (-3.4A)
AMP  A 501 (-3.9A)
AMP  A 501 ( 2.8A)
None
 1.14A 2dpmA-6gbcA:
undetectable		 2dpmA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		3 / 3 SER A 394
ARG A 374
GLN A 398
 None
 0.96A 2xnrA-6gbcA:
undetectable		 2xnrA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		4 / 8 ALA A 178
TYR A  41
GLY A 175
ILE A 174
 None
 0.81A 2zm9A-6gbcA:
undetectable		 2zm9A-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 9 GLY A 181
ALA A 180
VAL A 162
GLY A 175
ILE A 174
 None
 1.02A 3ektA-6gbcA:
undetectable		 3ektA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 12 LEU A 176
ALA A  54
ASP A 159
GLY A 153
VAL A 162
 None
None
None
CSX  A 154 ( 2.4A)
None
 1.18A 3gguA-6gbcA:
undetectable		 3gguA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 10 GLY A 181
ALA A 180
GLY A 175
ILE A 174
ILE A  52
 None
 0.87A 3nu6B-6gbcA:
undetectable		 3nu6B-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 9 GLY A 181
ALA A 180
ILE A 156
GLY A 175
ILE A 174
 None
 0.94A 3ogpA-6gbcA:
undetectable		 3ogpA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 9 GLY A 346
ALA A 345
ILE A 341
GLY A  45
ILE A 169
 None
 0.93A 3ogpB-6gbcA:
undetectable		 3ogpB-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 10 GLY A 181
ALA A 180
GLY A 175
ILE A 174
ILE A  52
 None
 0.96A 3s43B-6gbcA:
undetectable		 3s43B-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 11 ALA A 411
ALA A 409
ALA A 375
LEU A 415
GLN A 398
 None
 1.15A 4jbtB-6gbcA:
undetectable		 4jbtB-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 10 GLY A 181
ALA A 180
VAL A 162
GLY A 175
ILE A 174
 None
 1.00A 4njtB-6gbcA:
undetectable		 4njtB-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 9 GLY A 181
ALA A 180
GLY A 175
ILE A 174
ILE A  52
 None
 0.92A 4rvjD-6gbcA:
undetectable		 4rvjD-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		3 / 3 ARG A 220
ILE A 195
SER A 197
 None
None
AMP  A 501 (-2.8A)
 0.81A 5zw2A-6gbcA:
undetectable		 5zw2A-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 12 GLY A 181
ALA A 180
GLY A 175
ILE A 174
ILE A  52
 None
 0.90A 6difB-6gbcA:
undetectable		 6difB-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		4 / 5 PHE A 336
VAL A 268
PRO A 295
MET A 293
 None
 1.36A 6ekzA-6gbcA:
undetectable		 6ekzA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		4 / 8 ARG A  24
GLU A  21
VAL A 291
GLN A 343
 None
 1.19A 6fbvD-6gbcA:
undetectable		 6fbvD-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		3 / 3 VAL A 203
ALA A 207
GLN A 214
 None
 0.06A 6gb9A-6gbcA:
52.8		 6gb9A-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		3 / 3 LYS A 294
SER A 328
SER A 400
 None
MOO  A 507 (-2.7A)
MOO  A 507 (-2.6A)
 0.49A 6gbfA-6gbcA:
53.4		 6gbfA-6gbcA:
undetectable