SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 5 ILE C 115
ARG C  68
LEU C 109
PRO C 106
 None
 1.48A 1s8fA-6gc6C:
undetectable
1s8fB-6gc6C:
undetectable		 1s8fA-6gc6C:
undetectable
1s8fB-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		3 / 3 THR C   8
SER C   9
ARG C  12
 G  A1695 ( 3.6A)
G  A 729 ( 3.1A)
A  A 727 ( 3.4A)
 0.78A 3phnA-6gc6C:
undetectable		 3phnA-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 6 ARG C 188
ILE C 134
VAL C 140
LEU C 191
 None
 1.06A 4em2A-6gc6C:
undetectable		 4em2A-6gc6C:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 GLU C 144
VAL C 143
THR C 128
ARG C 188
GLY C  72
 None
 1.34A 4q15A-6gc6C:
undetectable		 4q15A-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 GLU C 144
VAL C 143
THR C 128
ARG C 188
GLY C  72
 None
 1.30A 4q15B-6gc6C:
undetectable		 4q15B-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 GLY C 195
ILE C  73
TYR C  95
GLY C  72
GLY C 118
 None
A  A1490 ( 4.9A)
None
None
None
 1.05A 5eqbA-6gc6C:
undetectable		 5eqbA-6gc6C:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 5 GLY C 168
ASP C 167
ARG C 166
MET C 180
 None
 1.13A 5gwkA-6gc6C:
undetectable		 5gwkA-6gc6C:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 PRO C 125
GLY C 108
ASP C  65
ARG C 101
TYR C  95
 None
 1.15A 5zvgA-6gc6C:
undetectable		 5zvgA-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6gc6 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 PRO C 125
GLY C 108
ASP C  65
ARG C 101
TYR C  95
 None
 1.15A 5zvgB-6gc6C:
undetectable		 5zvgB-6gc6C:
undetectable