SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		3 / 3 TRP A 275
VAL A 270
TRP A 272
 None
 1.46A 1gmkC-6gctA:
undetectable
1gmkD-6gctA:
undetectable		 1gmkC-6gctA:
undetectable
1gmkD-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 4 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.32A 1h1dA-6gctA:
undetectable		 1h1dA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 5 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.31A 1vidA-6gctA:
undetectable		 1vidA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 GLY A 480
LEU A 337
LEU A 321
PRO A 322
PHE A 328
 None
 0.92A 1zq9B-6gctA:
undetectable		 1zq9B-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 6 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.33A 2cl5B-6gctA:
undetectable		 2cl5B-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 ALA A 429
GLY A 434
THR A 384
MET A 267
LEU A 107
 GLN  A 601 (-4.5A)
GLN  A 601 ( 4.8A)
None
None
None
 1.08A 2hw2A-6gctA:
undetectable		 2hw2A-6gctA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 SER A 424
ILE A 442
PHE A 393
ALA A 390
ALA A 142
 None
None
None
GLN  A 601 ( 4.1A)
None
 1.15A 2j0dA-6gctA:
undetectable		 2j0dA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 6 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.36A 2zvjA-6gctA:
undetectable		 2zvjA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 7 ILE A 453
ILE A 431
LEU A 443
LEU A 107
 None
 0.94A 3adxA-6gctA:
undetectable		 3adxA-6gctA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 8 PHE A 400
ALA A 397
VAL A 463
VAL A 459
 None
 0.89A 3me6B-6gctA:
undetectable		 3me6B-6gctA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 11 GLU A 473
GLY A 478
ALA A 476
ILE A 378
ALA A 131
 None
 1.23A 3nmuB-6gctA:
2.0
3nmuJ-6gctA:
undetectable		 3nmuB-6gctA:
undetectable
3nmuJ-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 8 THR A 416
LEU A 187
VAL A 235
ILE A 231
 None
 1.00A 4l4cB-6gctA:
undetectable		 4l4cB-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 ALA A 428
ILE A 281
LEU A 100
LEU A  97
GLY A  93
 None
 1.11A 4l9qB-6gctA:
2.0		 4l9qB-6gctA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 LEU A 149
ALA A 157
LYS A 304
TYR A 305
HIS A 313
 None
 1.15A 4l9qB-6gctA:
2.0		 4l9qB-6gctA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 TYR A 325
ALA A 479
GLY A 478
ASN A 484
ASN A 368
 None
 1.01A 4obwA-6gctA:
undetectable		 4obwA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 4 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.32A 4xucA-6gctA:
undetectable		 4xucA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 LEU A 439
GLY A 427
ILE A 453
GLY A 434
GLY A 435
 None
None
None
GLN  A 601 ( 4.8A)
GLN  A 601 (-3.4A)
 1.02A 4yvgA-6gctA:
undetectable		 4yvgA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 5 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.32A 5fhrA-6gctA:
undetectable		 5fhrA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 5 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.32A 5fhrB-6gctA:
undetectable		 5fhrB-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 ILE A 340
LEU A 477
PHE A 336
ARG A 335
GLY A 339
 None
 1.32A 5il1A-6gctA:
undetectable		 5il1A-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 6 VAL A 270
SER A 111
ILE A 113
PHE A 259
 None
 1.04A 5jw1B-6gctA:
undetectable		 5jw1B-6gctA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 8 SER A 183
ASP A 186
SER A 408
SER A 203
 None
 0.90A 5l1fA-6gctA:
undetectable
5l1fB-6gctA:
undetectable		 5l1fA-6gctA:
8.71
5l1fB-6gctA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 12 ILE A 441
ILE A 417
LEU A 443
THR A 438
LEU A 439
 None
 1.01A 5twjA-6gctA:
undetectable		 5twjA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		6 / 12 VAL A 370
ILE A 374
ILE A 378
ASP A 475
LEU A 379
VAL A 364
 None
 1.37A 5uvmB-6gctA:
undetectable		 5uvmB-6gctA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 5 ASN A 190
ASP A 186
ASP A 410
ASN A 447
 None
 1.44A 5vooA-6gctA:
undetectable		 5vooA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		4 / 5 ASN A 190
ASP A 186
ASP A 410
ASN A 447
 None
 1.45A 5vooC-6gctA:
undetectable		 5vooC-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		3 / 3 PRO A 432
SER A 352
SER A 351
 None
 0.41A 6bpyA-6gctA:
undetectable		 6bpyA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 11 PHE A 393
THR A 438
GLY A 434
ILE A 456
ILE A 453
 None
None
GLN  A 601 ( 4.8A)
None
None
 1.07A 6ebzB-6gctA:
undetectable		 6ebzB-6gctA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens) 		5 / 11 PHE A 393
THR A 438
GLY A 434
ILE A 456
ILE A 453
 None
None
GLN  A 601 ( 4.8A)
None
None
 1.07A 6ebzC-6gctA:
undetectable		 6ebzC-6gctA:
21.11