SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 6gdg NANOBODY NB35
(Lama
glama) 		4 / 7 LEU E  81
THR E  61
TYR E  60
LYS E  65
 None
 1.17A 1rmtB-6gdgE:
undetectable		 1rmtB-6gdgE:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A  81
PHE A  79
LEU A 137
VAL A 171
VAL A 172
 None
 1.15A 1ukbA-6gdgA:
undetectable		 1ukbA-6gdgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 HIS A 250
ASN A 253
ILE A 251
PHE A 255
 NEC  A 400 (-4.5A)
NEC  A 400 (-3.5A)
None
None
 0.87A 1xf1B-6gdgA:
undetectable		 1xf1B-6gdgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.97A 2aclC-6gdgA:
undetectable		 2aclC-6gdgA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.98A 2aclE-6gdgA:
undetectable		 2aclE-6gdgA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TYR A 288
TYR A 197
ILE A 100
ILE A  98
 None
 1.16A 2dcfA-6gdgA:
undetectable		 2dcfA-6gdgA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		10 / 12 LEU A  85
THR A  88
MET A 177
TRP A 246
LEU A 249
ASN A 253
MET A 270
ILE A 274
SER A 277
HIS A 278
 NEC  A 400 ( 4.5A)
NEC  A 400 (-3.8A)
NEC  A 400 (-4.3A)
None
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
NEC  A 400 (-3.5A)
NEC  A 400 (-3.7A)
 0.61A 2ydoA-6gdgA:
34.7		 2ydoA-6gdgA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 288
TYR A 197
ILE A 100
ILE A  98
 None
 1.16A 2zm7A-6gdgA:
undetectable		 2zm7A-6gdgA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 9 LEU A 241
ILE A  98
ILE A  92
VAL A 283
ILE A 287
 None
 1.14A 3d1yB-6gdgA:
undetectable		 3d1yB-6gdgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 203
ALA A 204
GLN A 207
VAL A 239
ILE A 238
 None
 1.07A 3e00A-6gdgA:
undetectable		 3e00A-6gdgA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A 203
ALA A 204
GLN A 207
VAL A 239
ILE A 238
 None
 0.94A 3falA-6gdgA:
2.1		 3falA-6gdgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.90A 3falA-6gdgA:
2.1		 3falA-6gdgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.94A 3falC-6gdgA:
2.1		 3falC-6gdgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 7 MET A 174
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 ( 4.7A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
 1.40A 3rfmA-6gdgA:
28.6		 3rfmA-6gdgA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 7 MET A 177
LEU A 249
ASN A 253
ILE A 274
 NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
NEC  A 400 (-4.2A)
 0.65A 3rfmA-6gdgA:
28.6		 3rfmA-6gdgA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PHE A  93
ALA A  97
PRO A 189
LEU A  95
 None
 0.96A 5dzkD-6gdgA:
undetectable
5dzkR-6gdgA:
undetectable		 5dzkD-6gdgA:
undetectable
5dzkR-6gdgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A 127
LEU A 131
VAL A 188
ILE A 100
LEU A 192
 None
 1.02A 5ienB-6gdgA:
undetectable		 5ienB-6gdgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		6 / 8 LEU A  85
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 ( 4.5A)
NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
 0.63A 5mzjA-6gdgA:
29.4		 5mzjA-6gdgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		6 / 9 ILE A  66
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
None
NEC  A 400 (-4.2A)
 0.41A 5mzpA-6gdgA:
29.4		 5mzpA-6gdgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.91A 6a5zL-6gdgA:
undetectable		 6a5zL-6gdgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 0.98A 6a60D-6gdgA:
undetectable		 6a60D-6gdgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6gdg TRXA,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		7 / 10 VAL A  84
THR A  88
MET A 177
LEU A 249
ASN A 253
ILE A 274
HIS A 278
 None
NEC  A 400 (-3.8A)
NEC  A 400 (-4.3A)
NEC  A 400 (-4.9A)
NEC  A 400 (-3.5A)
NEC  A 400 (-4.2A)
NEC  A 400 (-3.7A)
 0.67A 6d9hR-6gdgA:
35.2		 6d9hR-6gdgA:
18.39