SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 6gdt -
(-) 		5 / 10 GLU A 299
ARG A 333
LEU A 291
LEU A 286
GLY A 250
 None
 1.27A 1cmcA-6gdtA:
undetectable
1cmcB-6gdtA:
undetectable		 1cmcA-6gdtA:
undetectable
1cmcB-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 6gdt -
(-) 		4 / 5 PHE A  67
TYR A  10
LEU A 482
VAL A  32
 None
 1.40A 1dz6A-6gdtA:
undetectable		 1dz6A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6gdt -
(-) 		4 / 8 GLN A 110
VAL A 166
GLY A 137
GLY A 198
 None
 0.73A 1f5lA-6gdtA:
undetectable		 1f5lA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_B_HSMB601_1
(HISTAMINE
N-METHYLTRANSFERASE)		 6gdt -
(-) 		5 / 10 PHE A  62
GLN A  59
TYR A 485
TRP A  57
PHE A 409
 None
 1.11A 1jqdB-6gdtA:
0.0		 1jqdB-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6gdt -
(-) 		3 / 3 SER A 435
GLY A 436
ARG A 543
 None
 0.64A 1t9wA-6gdtA:
undetectable		 1t9wA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6gdt -
(-) 		5 / 12 LEU A   2
LEU A 482
ALA A  18
GLN A  17
THR A  83
 None
 1.39A 1ya3A-6gdtA:
undetectable		 1ya3A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 6gdt -
(-) 		5 / 12 LEU A   2
LEU A 482
ALA A  18
GLN A  17
THR A  83
 None
 1.41A 2aa5B-6gdtA:
undetectable		 2aa5B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_1
(MINERALOCORTICOID
RECEPTOR)		 6gdt -
(-) 		5 / 12 LEU A   2
ALA A  18
GLN A  17
PHE A 409
THR A  83
 None
 1.36A 2ab2A-6gdtA:
undetectable		 2ab2A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 6gdt -
(-) 		5 / 12 LEU A   2
ALA A  18
GLN A  17
PHE A 409
THR A  83
 None
 1.36A 2ab2B-6gdtA:
undetectable		 2ab2B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6gdt -
(-) 		4 / 7 LEU A 399
ALA A 453
LEU A 449
ALA A 475
 None
 0.97A 2vcvG-6gdtA:
1.6		 2vcvG-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6gdt -
(-) 		4 / 8 ASP A 242
SER A 153
TYR A 148
TYR A 232
 None
 1.04A 2xz5A-6gdtA:
undetectable
2xz5C-6gdtA:
undetectable		 2xz5A-6gdtA:
undetectable
2xz5C-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6gdt -
(-) 		4 / 8 ASP A 242
SER A 153
TYR A 232
CYH A 230
 None
 1.28A 2xz5A-6gdtA:
undetectable
2xz5C-6gdtA:
undetectable		 2xz5A-6gdtA:
undetectable
2xz5C-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 6gdt -
(-) 		4 / 7 ASN A 169
ALA A 257
ALA A 256
ALA A 260
 None
 0.79A 3a2qA-6gdtA:
undetectable		 3a2qA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 6gdt -
(-) 		4 / 6 GLN A  61
GLY A  60
HIS A  63
HIS A  51
 None
 1.50A 3ai8B-6gdtA:
undetectable		 3ai8B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 6gdt -
(-) 		4 / 8 LYS A 510
ASN A 496
PRO A 484
PHE A  62
 None
 1.38A 3bjwD-6gdtA:
undetectable		 3bjwD-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6gdt -
(-) 		6 / 12 PHE A 247
LEU A 286
GLY A 250
GLY A 246
ALA A 254
LEU A 366
 None
 1.29A 3dh0B-6gdtA:
undetectable		 3dh0B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6gdt -
(-) 		4 / 5 TYR A 454
GLN A 562
ILE A  90
PHE A 566
 None
 1.03A 3ls4L-6gdtA:
6.3		 3ls4L-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6gdt -
(-) 		6 / 12 ALA A 361
ASN A 433
LEU A 158
ARG A 543
THR A 518
GLY A 441
 None
 1.22A 3mzeA-6gdtA:
undetectable		 3mzeA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6gdt -
(-) 		5 / 12 LEU A 309
ALA A 257
LEU A 171
ARG A 263
ILE A 369
 None
 1.31A 3olsB-6gdtA:
undetectable		 3olsB-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 6gdt -
(-) 		5 / 8 ASN A 433
SER A 362
HIS A 360
GLU A 546
TRP A 542
 None
 1.50A 3sg9B-6gdtA:
undetectable		 3sg9B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6gdt -
(-) 		5 / 12 GLY A 250
GLY A 252
ILE A 255
ARG A 248
ALA A 245
 None
 0.95A 3uj7B-6gdtA:
undetectable		 3uj7B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 6gdt -
(-) 		4 / 8 GLY A 237
LEU A 152
TYR A 232
TRP A 438
 None
 0.90A 4m5mA-6gdtA:
undetectable		 4m5mA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6gdt -
(-) 		4 / 8 THR A 163
GLY A 137
GLY A 136
ASP A 133
 None
 0.68A 4qvvK-6gdtA:
undetectable
4qvvL-6gdtA:
undetectable		 4qvvK-6gdtA:
undetectable
4qvvL-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6gdt -
(-) 		4 / 8 THR A 163
GLY A 137
GLY A 136
ASP A 133
 None
 0.69A 4qvvY-6gdtA:
undetectable
4qvvZ-6gdtA:
undetectable		 4qvvY-6gdtA:
undetectable
4qvvZ-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 6gdt -
(-) 		3 / 3 GLU A 442
ILE A 401
ALA A 475
 None
 0.50A 4wnwB-6gdtA:
undetectable		 4wnwB-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 6gdt -
(-) 		3 / 3 ARG A 227
ASP A 120
TYR A 139
 None
 0.92A 4yo9B-6gdtA:
undetectable		 4yo9B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 6gdt -
(-) 		12 / 12 ASP A 140
ALA A 141
ASP A 144
TYR A 148
HIS A 151
TRP A 220
TRP A 438
GLN A 440
ASN A 515
TRP A 542
GLU A 546
TRP A 548
 None
 0.31A 5dgrA-6gdtA:
66.8		 5dgrA-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_B_GCSB602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 6gdt -
(-) 		11 / 11 ALA A 141
ASP A 144
TYR A 148
HIS A 151
TRP A 220
TRP A 438
GLN A 440
ASN A 515
TRP A 542
GLU A 546
TRP A 548
 None
 0.27A 5dgrB-6gdtA:
61.4		 5dgrB-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6gdt -
(-) 		5 / 12 GLU A 313
THR A 189
ARG A 263
GLY A 173
LEU A 174
 None
 1.35A 5m50B-6gdtA:
undetectable		 5m50B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6gdt -
(-) 		5 / 12 GLU A 313
THR A 189
ARG A 263
GLY A 173
LEU A 174
 None
 1.33A 5m50E-6gdtA:
undetectable		 5m50E-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 6gdt -
(-) 		5 / 12 ASN A 169
LEU A 171
GLY A 173
VAL A 176
ARG A 263
 None
 0.86A 5uc1B-6gdtA:
undetectable		 5uc1B-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6gdt -
(-) 		3 / 3 ASP A 432
PHE A 359
ARG A 356
 None
 1.06A 5yw0A-6gdtA:
undetectable		 5yw0A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 6gdt -
(-) 		3 / 3 ILE A   8
ASN A 497
CYH A 514
 None
 0.76A 6bp4A-6gdtA:
undetectable		 6bp4A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gdt -
(-) 		5 / 12 GLY A 210
ILE A 549
GLY A 137
LEU A 202
MET A 205
 None
 1.19A 6e8qA-6gdtA:
undetectable		 6e8qA-6gdtA:
undetectable