SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ged'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 6ged PRGB
(Enterococcus
faecalis) 		3 / 3 ASP A 310
GLU A 455
TYR A 490
 None
NA  A 601 (-2.9A)
EDO  A 602 ( 4.8A)
 0.80A 1wsvA-6gedA:
undetectable		 1wsvA-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6ged PRGB
(Enterococcus
faecalis) 		4 / 5 SER A 383
SER A 381
THR A 404
ASN A 389
 None
 1.46A 1yvpA-6gedA:
undetectable		 1yvpA-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6ged PRGB
(Enterococcus
faecalis) 		4 / 5 SER A 383
SER A 385
THR A 404
ASN A 389
 None
 1.10A 1yvpA-6gedA:
undetectable		 1yvpA-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6ged PRGB
(Enterococcus
faecalis) 		4 / 6 SER A 383
SER A 385
THR A 404
ASN A 389
 None
 1.02A 1yvpB-6gedA:
undetectable		 1yvpB-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6ged PRGB
(Enterococcus
faecalis) 		6 / 12 LEU A 273
LEU A 551
PHE A 420
ILE A 523
ALA A 519
LEU A 518
 None
 1.42A 3n8xB-6gedA:
undetectable		 3n8xB-6gedA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ged PRGB
(Enterococcus
faecalis) 		4 / 5 ARG A 406
ASP A 411
GLU A 455
VAL A 474
 None
None
NA  A 601 (-2.9A)
None
 1.26A 4nkxD-6gedA:
undetectable		 4nkxD-6gedA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 12 ASN A 304
ILE A 295
LEU A 346
GLY A 403
SER A 541
 None
 1.15A 4o1eB-6gedA:
undetectable		 4o1eB-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 12 VAL A 355
LEU A 416
ILE A 402
LEU A 347
THR A 414
 None
 1.30A 4o5fA-6gedA:
undetectable
4o5fB-6gedA:
undetectable		 4o5fA-6gedA:
undetectable
4o5fB-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 9 ILE A 295
VAL A 391
ALA A 390
VAL A 412
ALA A 542
 None
 1.26A 4oqrA-6gedA:
undetectable		 4oqrA-6gedA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 11 ALA A 553
VAL A 474
GLY A 517
PHE A 466
SER A 441
 None
 1.16A 4xp4A-6gedA:
undetectable		 4xp4A-6gedA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 10 PHE A 275
THR A 549
ILE A 369
ILE A 418
ILE A 523
 None
 1.02A 6ebpD-6gedA:
undetectable		 6ebpD-6gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 11 PHE A 275
THR A 549
ILE A 369
ILE A 418
ILE A 523
 None
 1.04A 6ebzA-6gedA:
undetectable		 6ebzA-6gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 11 PHE A 275
THR A 549
ILE A 369
ILE A 418
ILE A 523
 None
 1.05A 6ebzB-6gedA:
undetectable		 6ebzB-6gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 11 PHE A 275
THR A 549
ILE A 369
ILE A 418
ILE A 523
 None
 1.01A 6ebzC-6gedA:
undetectable		 6ebzC-6gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6ged PRGB
(Enterococcus
faecalis) 		5 / 11 PHE A 275
THR A 549
ILE A 369
ILE A 418
ILE A 523
 None
 1.04A 6ebzD-6gedA:
undetectable		 6ebzD-6gedA:
20.24