SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		5 / 12 ILE A 334
ALA A 189
LEU A 201
ILE A 433
MET A 443
 None
 1.29A 2xkwB-6giiA:
undetectable		 2xkwB-6giiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		3 / 3 ALA A 308
THR A 312
CYH A 419
 HEM  A 501 (-3.7A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.4A)
 0.51A 3e4eA-6giiA:
29.6		 3e4eA-6giiA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		3 / 3 ALA A 308
THR A 312
CYH A 419
 HEM  A 501 (-3.7A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.4A)
 0.44A 3e4eB-6giiA:
29.6		 3e4eB-6giiA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 8 VAL A 293
MET A 302
ILE A 283
GLN A 286
 None
 1.07A 3remA-6giiA:
undetectable		 3remA-6giiA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 8 GLY A 219
VAL A 220
ILE A 305
PHE A 170
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.2A)
 0.91A 4fglD-6giiA:
undetectable		 4fglD-6giiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		5 / 12 ASP A 200
THR A 318
VAL A 314
ASP A 203
GLU A 311
 None
 1.17A 4i41A-6giiA:
undetectable		 4i41A-6giiA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 5 VAL A 456
TYR A 351
ILE A 401
PRO A 354
 None
None
None
HEM  A 501 ( 4.1A)
 1.25A 4ze1A-6giiA:
undetectable		 4ze1A-6giiA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		3 / 3 LEU A 215
LEU A 218
TRP A 278
 None
 0.81A 5nwuA-6giiA:
undetectable		 5nwuA-6giiA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		3 / 3 ARG A 459
PRO A 461
TYR A 351
 None
 0.79A 5tzoB-6giiA:
undetectable		 5tzoB-6giiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		5 / 12 LEU A 151
PHE A 412
GLY A 421
ILE A 305
LEU A 349
 HEM  A 501 (-3.7A)
HEM  A 501 (-3.7A)
HEM  A 501 (-3.5A)
HEM  A 501 ( 4.4A)
None
 1.21A 5y2tA-6giiA:
undetectable		 5y2tA-6giiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 4 ARG A 403
ARG A 350
GLY A 353
ARG A 459
 None
 1.32A 6az3P-6giiA:
undetectable		 6az3P-6giiA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		5 / 12 LEU A  99
VAL A 103
THR A 105
ALA A  87
PHE A  83
 None
 1.33A 6drxA-6giiA:
undetectable		 6drxA-6giiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 6 ASP A  79
TYR A 351
GLU A 397
GLU A  89
 None
 1.38A 6mn5A-6giiA:
undetectable		 6mn5A-6giiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6gii CYTOCHROME P450
(Tepidiphilus
thermophilus) 		4 / 6 ASP A  79
TYR A 351
GLU A 397
GLU A  89
 None
 1.37A 6mn5C-6giiA:
undetectable		 6mn5C-6giiA:
20.69