SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 6gk6 -
(-) 		5 / 12 GLU A 246
VAL A 249
ILE A 252
ILE A 122
ILE A 366
 None
 1.05A 1fapA-6gk6A:
undetectable		 1fapA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 6gk6 -
(-) 		3 / 3 ALA A 317
VAL A 315
TRP A 297
 None
 0.89A 1tkqB-6gk6A:
undetectable		 1tkqB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6gk6 -
(-) 		5 / 10 GLU A 287
LEU A 258
SER A 261
THR A 384
ALA A  17
 None
 1.29A 1wygA-6gk6A:
undetectable		 1wygA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 6gk6 -
(-) 		5 / 12 PRO A  79
PRO A 393
VAL A  73
ILE A 295
LEU A  69
 None
 1.35A 1z9hA-6gk6A:
undetectable		 1z9hA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 6gk6 -
(-) 		5 / 12 PRO A  79
PRO A 393
VAL A  73
ILE A 295
LEU A  69
 None
 1.36A 1z9hB-6gk6A:
undetectable		 1z9hB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 6gk6 -
(-) 		5 / 12 PRO A  79
PRO A 393
VAL A  73
ILE A 295
LEU A  69
 None
 1.36A 1z9hC-6gk6A:
undetectable		 1z9hC-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 6gk6 -
(-) 		5 / 9 THR A 294
HIS A 245
ALA A 243
LEU A 239
LEU A 359
 HEM  A 501 (-2.9A)
None
HEM  A 501 ( 3.5A)
HEM  A 501 ( 4.7A)
HEM  A 501 ( 4.5A)
 1.22A 2azqA-6gk6A:
0.0		 2azqA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 6gk6 -
(-) 		5 / 10 ILE A 125
VAL A 153
ALA A 152
ILE A 252
VAL A 249
 None
 0.87A 2nnjA-6gk6A:
30.7		 2nnjA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 6gk6 -
(-) 		5 / 12 LEU A 141
PHE A 368
ALA A 126
VAL A 280
GLY A 255
 None
 1.14A 3c6gB-6gk6A:
32.4		 3c6gB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 6gk6 -
(-) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A 501 ( 3.5A)
HEM  A 501 ( 3.4A)
HEM  A 501 (-2.3A)
 0.39A 3e4eA-6gk6A:
31.1		 3e4eA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 6gk6 -
(-) 		3 / 3 ALA A 243
THR A 247
CYH A 354
 HEM  A 501 ( 3.5A)
HEM  A 501 ( 3.4A)
HEM  A 501 (-2.3A)
 0.22A 3e4eB-6gk6A:
31.0		 3e4eB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6gk6 -
(-) 		4 / 4 LEU A 129
ALA A 152
VAL A 153
PRO A 150
 None
 1.14A 3gv1B-6gk6A:
undetectable		 3gv1B-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 6gk6 -
(-) 		4 / 6 LEU A 233
GLU A 222
SER A 234
PHE A  86
 None
 1.44A 3i9jB-6gk6A:
undetectable		 3i9jB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 6gk6 -
(-) 		5 / 12 GLY A 255
ALA A 367
ALA A 364
THR A 248
LEU A 251
 None
None
None
HEM  A 501 (-4.4A)
HEM  A 501 (-3.5A)
 1.03A 3p2kA-6gk6A:
undetectable		 3p2kA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 6gk6 -
(-) 		4 / 6 LEU A 258
GLU A 287
SER A 261
THR A 384
 None
 1.47A 3ropA-6gk6A:
undetectable		 3ropA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.28A 4cwxA-6gk6A:
undetectable
4cwxB-6gk6A:
undetectable		 4cwxA-6gk6A:
undetectable
4cwxB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 VAL A 309
TRP A  45
TRP A 297
GLU A 313
 None
 1.29A 4cwyA-6gk6A:
undetectable
4cwyB-6gk6A:
undetectable		 4cwyA-6gk6A:
undetectable
4cwyB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.28A 4cwyA-6gk6A:
undetectable
4cwyB-6gk6A:
undetectable		 4cwyA-6gk6A:
undetectable
4cwyB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 6gk6 -
(-) 		5 / 12 LEU A 214
PHE A 110
MET A 115
GLY A 117
LEU A 118
 None
HEM  A 501 ( 4.4A)
None
None
None
 1.24A 4j7xB-6gk6A:
undetectable		 4j7xB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6gk6 -
(-) 		4 / 6 TYR A  23
VAL A  48
HIS A  33
TRP A 392
 None
 1.39A 4jtrB-6gk6A:
undetectable		 4jtrB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6gk6 -
(-) 		3 / 3 LEU A 175
ILE A 174
ARG A 170
 None
 0.72A 4mk4B-6gk6A:
undetectable		 4mk4B-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 6gk6 -
(-) 		5 / 7 LEU A  92
THR A 247
ALA A 290
ARG A 296
ILE A 395
 HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.4A)
HEM  A 501 (-3.6A)
HEM  A 501 (-3.0A)
None
 0.72A 4ubsA-6gk6A:
48.4		 4ubsA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 6gk6 -
(-) 		3 / 3 VAL A  36
ALA A   6
PHE A  11
 None
 0.87A 4z4iA-6gk6A:
undetectable		 4z4iA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6gk6 -
(-) 		4 / 6 ARG A 296
HIS A  99
ARG A 103
ILE A 351
 HEM  A 501 (-3.0A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.8A)
None
 1.31A 5a06A-6gk6A:
undetectable		 5a06A-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA612_0
(SERUM ALBUMIN)		 6gk6 -
(-) 		4 / 4 SER A  15
HIS A  12
GLU A   9
PRO A   8
 None
 1.47A 5dbyA-6gk6A:
0.0		 5dbyA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 6gk6 -
(-) 		5 / 10 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A 501 ( 4.5A)
HEM  A 501 (-3.5A)
HEM  A 501 ( 4.5A)
None
None
 1.35A 5dx3A-6gk6A:
undetectable		 5dx3A-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 6gk6 -
(-) 		5 / 12 LEU A 359
ALA A 360
GLU A 363
GLY A 288
LEU A 284
 HEM  A 501 ( 4.5A)
HEM  A 501 (-3.5A)
HEM  A 501 ( 4.5A)
None
None
 1.14A 5gtrA-6gk6A:
undetectable		 5gtrA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6gk6 -
(-) 		3 / 3 VAL A  36
ALA A   6
PHE A  11
 None
 0.87A 5js1A-6gk6A:
undetectable		 5js1A-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 6gk6 -
(-) 		5 / 12 ILE A 395
THR A 394
LEU A 251
VAL A 249
SER A 254
 None
None
HEM  A 501 (-3.5A)
None
None
 1.14A 5l8oB-6gk6A:
undetectable		 5l8oB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6gk6 -
(-) 		4 / 5 TYR A  23
ASP A 325
PRO A 326
ALA A 322
 None
 1.08A 5otrA-6gk6A:
undetectable		 5otrA-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 6gk6 -
(-) 		4 / 7 ARG A 121
GLU A 156
LEU A 129
ARG A 165
 None
 0.94A 5umwB-6gk6A:
undetectable
5umwE-6gk6A:
undetectable		 5umwB-6gk6A:
undetectable
5umwE-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.30A 5uo9C-6gk6A:
0.0
5uo9D-6gk6A:
undetectable		 5uo9C-6gk6A:
undetectable
5uo9D-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.33A 5vvdA-6gk6A:
undetectable
5vvdB-6gk6A:
undetectable		 5vvdA-6gk6A:
undetectable
5vvdB-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.32A 6av6A-6gk6A:
0.0
6av6B-6gk6A:
undetectable		 6av6A-6gk6A:
undetectable
6av6B-6gk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gk6 -
(-) 		4 / 7 TRP A  45
TRP A 297
GLU A 313
VAL A 309
 None
 1.35A 6cieA-6gk6A:
undetectable
6cieB-6gk6A:
undetectable		 6cieA-6gk6A:
undetectable
6cieB-6gk6A:
undetectable