SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		4 / 5 GLY H 199
GLN H 201
VAL H 193
SER H 196
 None
CL  H 302 (-4.4A)
None
None
 1.47A 1zzuB-6gk7H:
undetectable		 1zzuB-6gk7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 12 GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
 None
 1.07A 3keeA-6gk7H:
undetectable		 3keeA-6gk7H:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 12 GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
 None
 0.99A 3keeC-6gk7H:
undetectable		 3keeC-6gk7H:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 12 GLY H  54
SER H  30
ARG H 102
ALA H 101
ASP H 100
 None
 1.03A 3keeD-6gk7H:
undetectable		 3keeD-6gk7H:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 10 PHE H 131
GLY H 127
THR H 214
VAL H 207
VAL H 216
 None
 1.18A 4jx1B-6gk7H:
undetectable		 4jx1B-6gk7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.94A 5bxnH-6gk7H:
undetectable
5bxnI-6gk7H:
undetectable		 5bxnH-6gk7H:
15.90
5bxnI-6gk7H:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		4 / 5 GLU H  10
PRO H   9
THR H 116
GLN H 114
 None
 1.17A 6fgdA-6gk7H:
undetectable		 6fgdA-6gk7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 1.04A 6hwdH-6gk7H:
undetectable
6hwdI-6gk7H:
undetectable		 6hwdH-6gk7H:
20.21
6hwdI-6gk7H:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 6gk7 HUMAN FAB ANTIBODY
FRAGMENT OF
CBTAU-27.1(S31Y,T100
I)
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 1.04A 6hwdV-6gk7H:
undetectable		 6hwdV-6gk7H:
20.21