SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 12 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.33A 1q23B-6gl3A:
undetectable		 1q23B-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 12 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.35A 1q23C-6gl3A:
undetectable		 1q23C-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 10 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.28A 1q23E-6gl3A:
undetectable		 1q23E-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 11 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.32A 1q23I-6gl3A:
undetectable		 1q23I-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 11 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.33A 1q23J-6gl3A:
undetectable		 1q23J-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 10 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.23A 1q23K-6gl3A:
undetectable		 1q23K-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6gl3 -
(-) 		5 / 11 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.30A 1q23L-6gl3A:
undetectable		 1q23L-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 6gl3 -
(-) 		5 / 10 LEU A 785
LEU A 737
GLU A 752
ILE A 769
LEU A 666
 None
 1.25A 1wopA-6gl3A:
undetectable		 1wopA-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 6gl3 -
(-) 		5 / 12 ILE A 335
LEU A 352
VAL A 378
VAL A 367
PRO A 370
 None
 1.04A 2ygpA-6gl3A:
undetectable		 2ygpA-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 6gl3 -
(-) 		5 / 12 PRO A 370
THR A 371
MET A 609
ILE A 399
LEU A 359
 None
 1.34A 3a51B-6gl3A:
1.7		 3a51B-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6gl3 -
(-) 		5 / 12 SER A 656
LEU A 630
PHE A 634
ILE A 685
GLY A 720
 None
 0.96A 3nxuA-6gl3A:
undetectable		 3nxuA-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 6gl3 -
(-) 		3 / 3 TYR A 728
MET A 792
LEU A 662
 None
 0.98A 3vw1D-6gl3A:
undetectable		 3vw1D-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 6gl3 -
(-) 		4 / 7 VAL A 622
VAL A 717
PHE A 714
ILE A 677
 None
 0.85A 3zjqA-6gl3A:
undetectable		 3zjqA-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 6gl3 -
(-) 		4 / 7 VAL A 622
VAL A 717
PHE A 714
ILE A 677
 None
 0.84A 3zjqB-6gl3A:
undetectable		 3zjqB-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6gl3 -
(-) 		3 / 3 LEU A 734
ILE A 738
ARG A 741
 None
 0.46A 4mk4B-6gl3A:
undetectable		 4mk4B-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 6gl3 -
(-) 		4 / 5 ILE A 418
PRO A 549
HIS A 383
VAL A 378
 None
 1.28A 4s0vA-6gl3A:
undetectable		 4s0vA-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 6gl3 -
(-) 		5 / 12 PRO A 396
ILE A 562
TYR A 598
VAL A 613
ILE A 688
 None
None
EMW  A 801 (-3.5A)
EMW  A 801 (-4.1A)
EMW  A 801 (-3.5A)
 0.57A 4xe0A-6gl3A:
undetectable		 4xe0A-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 10 SER A 607
LEU A 569
ASP A 568
ILE A 329
PRO A 370
 None
 1.40A 6dlzB-6gl3A:
undetectable
6dlzC-6gl3A:
undetectable		 6dlzB-6gl3A:
undetectable
6dlzC-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 11 ILE A 329
PRO A 370
SER A 607
LEU A 569
ASP A 568
 None
 1.40A 6dlzA-6gl3A:
undetectable
6dlzD-6gl3A:
undetectable		 6dlzA-6gl3A:
undetectable
6dlzD-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 10 SER A 607
LEU A 569
ASP A 568
ILE A 329
PRO A 370
 None
 1.40A 6dm1B-6gl3A:
undetectable
6dm1C-6gl3A:
undetectable		 6dm1B-6gl3A:
undetectable
6dm1C-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 11 ILE A 329
PRO A 370
SER A 607
LEU A 569
ASP A 568
 None
 1.40A 6dm1A-6gl3A:
undetectable
6dm1D-6gl3A:
undetectable		 6dm1A-6gl3A:
undetectable
6dm1D-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 10 SER A 607
LEU A 569
ASP A 568
ILE A 329
PRO A 370
 None
 1.40A 6dm2B-6gl3A:
undetectable
6dm2C-6gl3A:
undetectable		 6dm2B-6gl3A:
undetectable
6dm2C-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6gl3 -
(-) 		5 / 10 ILE A 329
PRO A 370
SER A 607
LEU A 569
ASP A 568
 None
 1.41A 6dm2A-6gl3A:
undetectable
6dm2D-6gl3A:
undetectable		 6dm2A-6gl3A:
undetectable
6dm2D-6gl3A:
undetectable