SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 6gne -
(-) 		3 / 3 GLU A 113
TRP A 122
LYS A  52
 None
 1.09A 1qu2A-6gneA:
2.3		 1qu2A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6gne -
(-) 		5 / 12 LEU A 144
SER A 182
ALA A 183
VAL A  28
TYR A 171
 None
 1.21A 2japA-6gneA:
7.2		 2japA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6gne -
(-) 		5 / 12 LEU A 144
SER A 182
ALA A 183
VAL A  28
TYR A 171
 None
 1.23A 2japB-6gneA:
7.2		 2japB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6gne -
(-) 		5 / 12 LEU A 144
SER A 182
ALA A 183
VAL A  28
TYR A 171
 None
 1.19A 2japC-6gneA:
7.2		 2japC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6gne -
(-) 		5 / 12 LEU A 144
SER A 182
ALA A 183
VAL A  28
TYR A 171
 None
 1.20A 2japD-6gneA:
7.2		 2japD-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 6gne -
(-) 		5 / 12 SER A 238
VAL A 244
LEU A  43
HIS A 160
LEU A  50
 None
ACR  A 602 (-4.3A)
ACR  A 602 ( 4.7A)
None
None
 1.38A 2zlcA-6gneA:
undetectable		 2zlcA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 6gne -
(-) 		4 / 6 ILE A 185
TYR A 175
ILE A  30
HIS A  29
 None
 1.14A 3eteA-6gneA:
2.9
3eteE-6gneA:
2.7		 3eteA-6gneA:
undetectable
3eteE-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 6gne -
(-) 		4 / 5 ILE A 185
TYR A 175
ILE A  30
HIS A  29
 None
 1.12A 3eteB-6gneA:
2.8
3eteC-6gneA:
2.9		 3eteB-6gneA:
undetectable
3eteC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 6gne -
(-) 		4 / 7 ILE A  30
HIS A  29
ILE A 185
TYR A 175
 None
 1.14A 3eteD-6gneA:
2.8
3eteF-6gneA:
2.8		 3eteD-6gneA:
undetectable
3eteF-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6gne -
(-) 		3 / 3 ARG A 431
THR A 349
THR A 331
 None
 0.41A 3k2hB-6gneA:
1.7		 3k2hB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6gne -
(-) 		4 / 5 GLU A  62
LEU A 107
HIS A  29
GLY A  51
 None
 1.28A 3pp1A-6gneA:
undetectable		 3pp1A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 6gne -
(-) 		5 / 9 ASP A 442
GLY A 465
PRO A 408
ILE A 406
ILE A 429
 None
 0.99A 3s45A-6gneA:
undetectable		 3s45A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6gne -
(-) 		4 / 7 GLU A 370
PHE A 371
TYR A 347
VAL A 327
 None
 1.11A 4a97A-6gneA:
undetectable		 4a97A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6gne -
(-) 		4 / 6 GLU A 370
PHE A 371
TYR A 347
VAL A 327
 None
 1.05A 4a97I-6gneA:
undetectable		 4a97I-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 6gne -
(-) 		4 / 6 LEU A 387
LEU A 359
SER A 395
THR A 397
 None
ADP  A 601 ( 4.4A)
ADP  A 601 ( 4.2A)
None
 1.25A 4d7bB-6gneA:
undetectable		 4d7bB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 6gne -
(-) 		4 / 5 LEU A 352
ILE A 429
ALA A 345
PHE A 466
 None
 1.04A 4dc3B-6gneA:
6.0		 4dc3B-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 6gne -
(-) 		5 / 9 ALA A 168
TYR A 171
ALA A 183
ILE A 156
ILE A 157
 None
 1.13A 4eatB-6gneA:
2.7		 4eatB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 6gne -
(-) 		4 / 6 SER A 501
GLY A  42
ASP A  45
GLY A 415
 None
ADP  A 601 ( 3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.5A)
 0.86A 4koeA-6gneA:
undetectable
4koeB-6gneA:
undetectable
4koeC-6gneA:
2.6		 4koeA-6gneA:
undetectable
4koeB-6gneA:
undetectable
4koeC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 6gne -
(-) 		4 / 7 SER A 501
GLY A  42
ASP A  45
GLY A 415
 None
ADP  A 601 ( 3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.5A)
 0.89A 4koeA-6gneA:
undetectable
4koeB-6gneA:
undetectable
4koeD-6gneA:
2.5		 4koeA-6gneA:
undetectable
4koeB-6gneA:
undetectable
4koeD-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 6gne -
(-) 		4 / 8 ALA A 401
PHE A 356
THR A 349
PHE A 474
 None
 0.69A 4ltwA-6gneA:
undetectable		 4ltwA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 11 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.27A 4ygfA-6gneA:
undetectable		 4ygfA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 11 GLU A 506
HIS A  59
VAL A  61
VAL A  27
LEU A  50
 None
 1.43A 4ygfB-6gneA:
undetectable		 4ygfB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 11 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.27A 4ygfC-6gneA:
undetectable		 4ygfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		6 / 11 GLU A 506
HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.31A 4ygfD-6gneA:
undetectable		 4ygfD-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 12 GLU A 506
HIS A  59
VAL A  61
VAL A  27
LEU A  50
 None
 1.42A 4ygfE-6gneA:
undetectable		 4ygfE-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 12 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.22A 4ygfG-6gneA:
undetectable		 4ygfG-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 10 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.26A 4yhaB-6gneA:
undetectable		 4yhaB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 11 GLU A 506
HIS A  59
VAL A  61
LEU A  50
ALA A 502
 None
 1.40A 4yhaD-6gneA:
undetectable		 4yhaD-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 12 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.30A 4yhaG-6gneA:
undetectable		 4yhaG-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 10 GLU A 506
HIS A  59
VAL A  61
LEU A  50
ALA A 502
 None
 1.47A 4yhaH-6gneA:
undetectable		 4yhaH-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 6gne -
(-) 		4 / 6 GLY A  42
ASP A  45
GLY A 415
SER A 501
 ADP  A 601 ( 3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.5A)
None
 0.85A 4z53A-6gneA:
2.4
4z53B-6gneA:
undetectable		 4z53A-6gneA:
undetectable
4z53B-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 6gne -
(-) 		4 / 7 GLY A  42
ASP A  45
GLY A 415
SER A 501
 ADP  A 601 ( 3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.5A)
None
 0.89A 4z53A-6gneA:
2.4
4z53B-6gneA:
undetectable		 4z53A-6gneA:
undetectable
4z53B-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 6gne -
(-) 		4 / 6 ASP A 438
THR A 247
TYR A 248
THR A 243
 None
 1.47A 5b6iB-6gneA:
1.6		 5b6iB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6gne -
(-) 		4 / 6 TYR A 248
ASP A 161
ILE A 235
TYR A 505
 None
ACR  A 602 (-3.4A)
None
None
 1.30A 5ih0A-6gneA:
undetectable		 5ih0A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 6gne -
(-) 		4 / 6 LEU A 387
LEU A 359
SER A 395
THR A 397
 None
ADP  A 601 ( 4.4A)
ADP  A 601 ( 4.2A)
None
 1.19A 5l4iB-6gneA:
undetectable		 5l4iB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 10 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.28A 5tt3A-6gneA:
undetectable		 5tt3A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 9 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.23A 5tt3B-6gneA:
undetectable		 5tt3B-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 10 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.29A 5tt3C-6gneA:
undetectable		 5tt3C-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 9 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.25A 5tt3E-6gneA:
undetectable		 5tt3E-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6gne -
(-) 		5 / 9 HIS A  59
VAL A  61
VAL A  27
LEU A  50
ALA A 502
 None
 1.25A 5tt3G-6gneA:
undetectable		 5tt3G-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 6gne -
(-) 		5 / 12 LEU A 341
PHE A 458
ILE A 406
THR A 417
GLY A 434
 None
None
None
ADP  A 601 (-3.7A)
None
 1.06A 5veuA-6gneA:
undetectable		 5veuA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 6gne -
(-) 		5 / 12 GLN A  55
ALA A  53
GLU A 105
LEU A 107
ILE A  63
 None
 1.14A 5vlmG-6gneA:
undetectable		 5vlmG-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 6gne -
(-) 		8 / 10 GLY A  42
HIS A 190
VAL A 244
ASN A 277
LYS A 337
GLU A 412
PRO A 413
GLY A 415
 ADP  A 601 ( 3.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
ACR  A 602 (-3.3A)
ADP  A 601 (-2.8A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.49A 5vncC-6gneA:
24.0		 5vncC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gne -
(-) 		4 / 5 LEU A 352
PHE A 474
LEU A 470
PHE A 466
 None
 0.71A 5x19C-6gneA:
undetectable
5x19J-6gneA:
undetectable		 5x19C-6gneA:
undetectable
5x19J-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6gne -
(-) 		5 / 10 PHE A 441
GLY A 455
ILE A 407
ALA A 430
PHE A 272
 None
 1.17A 5zjiA-6gneA:
undetectable
5zjiJ-6gneA:
undetectable		 5zjiA-6gneA:
undetectable
5zjiJ-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 6gne -
(-) 		4 / 7 ASP A  45
ILE A 420
THR A 417
TYR A 390
 ADP  A 601 (-3.4A)
None
ADP  A 601 (-3.7A)
ADP  A 601 (-3.7A)
 1.00A 5zsfA-6gneA:
undetectable
5zsfB-6gneA:
undetectable		 5zsfA-6gneA:
undetectable
5zsfB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6gne -
(-) 		3 / 3 GLY A 435
THR A 247
GLU A 251
 None
 0.56A 6b58A-6gneA:
2.0		 6b58A-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 6gne -
(-) 		4 / 7 ASP A  91
SER A 205
GLY A 204
VAL A 210
 None
 0.79A 6ekzA-6gneA:
undetectable		 6ekzA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 6gne -
(-) 		6 / 12 ASP A 132
ASN A 277
ARG A 332
GLU A 412
PRO A 413
GLY A 415
 None
ACR  A 602 (-3.3A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.97A 6gnfA-6gneA:
33.5		 6gnfA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 6gne -
(-) 		9 / 12 VAL A  46
ASP A 161
ASN A 191
ASN A 277
ARG A 332
GLN A 336
GLU A 412
PRO A 413
GLY A 415
 ACR  A 602 (-4.9A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.3A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.53A 6gnfA-6gneA:
33.5		 6gnfA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 6gne -
(-) 		7 / 9 GLY A  41
GLY A  42
TYR A 127
TRP A 162
HIS A 190
VAL A 244
CYH A 414
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
ACR  A 602 (-4.3A)
 0.48A 6gnfA-6gneA:
42.1		 6gnfA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 6gne -
(-) 		5 / 10 GLY A  42
LEU A  43
SER A 362
HIS A 190
VAL A 244
 ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
None
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
 1.20A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 6gne -
(-) 		7 / 10 GLY A  42
LEU A  43
TYR A 127
TRP A 162
HIS A 190
VAL A 244
CYH A 414
 ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
ACR  A 602 (-4.3A)
 0.46A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 6gne -
(-) 		6 / 12 ASP A 132
ASN A 277
ARG A 332
GLU A 412
PRO A 413
GLY A 415
 None
ACR  A 602 (-3.3A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.94A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 6gne -
(-) 		9 / 12 VAL A  46
ASP A 161
ASN A 191
ASN A 277
ARG A 332
GLN A 336
GLU A 412
PRO A 413
GLY A 415
 ACR  A 602 (-4.9A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.3A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.53A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 6gne -
(-) 		5 / 12 GLY A  41
LEU A  43
VAL A  46
ASP A 132
ASN A 277
 ADP  A 601 ( 3.8A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
None
ACR  A 602 (-3.3A)
 0.84A 6gngA-6gneA:
42.2		 6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 6gne -
(-) 		7 / 12 GLY A  41
LEU A  43
VAL A  46
ASP A 161
ASN A 191
ASN A 277
GLN A 336
 ADP  A 601 ( 3.8A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.3A)
ACR  A 602 (-3.1A)
 0.53A 6gngA-6gneA:
42.2		 6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 6gne -
(-) 		5 / 12 GLY A  42
LEU A  43
ASP A 161
ASN A 191
GLN A 336
 ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.1A)
 0.91A 6gngA-6gneA:
42.2		 6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 6gne -
(-) 		5 / 12 GLU A  33
GLY A  41
TRP A 162
TYR A 194
GLU A 412
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.8A)
ACR  A 602 (-4.2A)
ACR  A 602 (-4.0A)
ACR  A 602 (-3.7A)
 1.28A 6gngA-6gneA:
42.2		 6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 6gne -
(-) 		11 / 12 GLU A  33
GLY A  42
TYR A 127
TRP A 162
HIS A 190
TYR A 194
VAL A 244
ARG A 332
GLU A 412
PRO A 413
GLY A 415
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.0A)
ACR  A 602 (-4.3A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.7A)
ACR  A 602 (-3.5A)
ADP  A 601 ( 3.5A)
 0.51A 6gngA-6gneA:
42.2		 6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 6gne -
(-) 		9 / 12 VAL A  46
TYR A 127
TRP A 162
HIS A 190
TYR A 194
VAL A 244
GLU A 412
CYH A 414
GLY A 415
 ACR  A 602 (-4.9A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.0A)
ACR  A 602 (-4.3A)
ACR  A 602 (-3.7A)
ACR  A 602 (-4.3A)
ADP  A 601 ( 3.5A)
 0.48A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 6gne -
(-) 		8 / 12 GLU A  33
GLY A  41
GLY A  42
LEU A  43
ASN A 191
ARG A 332
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.51A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 6gne -
(-) 		6 / 12 GLU A  33
GLY A  42
LEU A  43
ASN A 191
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.98A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 6gne -
(-) 		6 / 12 GLY A  41
GLY A  42
GLY A 128
ASN A 191
ARG A 332
PRO A 413
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.9A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.5A)
 1.34A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable