SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 11 LEU B 332
GLU B 328
VAL B 329
GLU B 210
TRP B 249
 None
F7E  B 402 (-2.9A)
None
NAP  B 403 ( 4.9A)
None
 1.23A 1mrqA-6gplB:
2.0		 1mrqA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 9 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.34A 1ncwH-6gplB:
undetectable
1ncwL-6gplB:
undetectable		 1ncwH-6gplB:
undetectable
1ncwL-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 9 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.29A 1ru9H-6gplB:
undetectable
1ru9L-6gplB:
undetectable		 1ru9H-6gplB:
undetectable
1ru9L-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 10 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.31A 1ruaH-6gplB:
undetectable
1ruaL-6gplB:
undetectable		 1ruaH-6gplB:
undetectable
1ruaL-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 9 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.31A 1rulH-6gplB:
undetectable
1rulL-6gplB:
undetectable		 1rulH-6gplB:
undetectable
1rulL-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 9 ALA B  26
TYR B 106
LEU B  27
GLY B  52
GLY B  30
 None
None
None
None
NAP  B 403 (-3.1A)
 1.32A 1rumH-6gplB:
undetectable
1rumL-6gplB:
undetectable		 1rumH-6gplB:
undetectable
1rumL-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 7 VAL B 306
VAL B 285
TYR B 231
CYH B 309
 None
 1.23A 1t46A-6gplB:
undetectable		 1t46A-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		3 / 3 VAL B 114
ASN B 208
TRP B 249
 F7E  B 402 (-4.1A)
F7E  B 402 ( 3.1A)
None
 1.08A 2y00B-6gplB:
undetectable		 2y00B-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 7 ASN B 192
ARG B 194
ASN B 203
ALA B 186
 None
EDO  B 405 ( 3.7A)
None
None
 1.20A 3frqB-6gplB:
undetectable		 3frqB-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 5 GLN B 341
THR B 337
GLU B 169
THR B 170
 None
 1.48A 3glqA-6gplB:
6.2		 3glqA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 5 GLN B 341
THR B 337
GLU B 169
THR B 170
 None
 1.46A 3glqB-6gplB:
5.9		 3glqB-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 12 GLU B 104
ILE B 105
PHE B 150
ALA B  26
ILE B  97
 None
 1.21A 3ndiA-6gplB:
2.0		 3ndiA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 9 ILE B  97
ILE B  96
LEU B  27
LEU B 135
ALA B 138
 None
 1.02A 3ozvB-6gplB:
5.8		 3ozvB-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 11 LEU B  39
GLU B 104
LEU B 263
MET B 262
GLY B 204
 None
 1.26A 3uudA-6gplB:
undetectable		 3uudA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 10 LEU B  39
GLU B 104
LEU B 263
MET B 262
GLY B 204
 None
 1.29A 5dxbA-6gplB:
undetectable		 5dxbA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 11 ILE B 105
THR B 132
VAL B 190
VAL B 202
LEU B 199
 None
 1.35A 5jkwA-6gplB:
undetectable		 5jkwA-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		5 / 12 LEU B  93
THR B  29
LEU B  27
GLY B  52
HIS B  83
 None
 1.39A 5v96D-6gplB:
6.5		 5v96D-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 6 SER B 156
GLU B 328
ARG B 325
ASP B 244
 F7E  B 402 (-3.5A)
F7E  B 402 (-2.9A)
F7E  B 402 (-3.2A)
None
 1.18A 5zw4A-6gplB:
8.0		 5zw4A-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		4 / 7 ARG B 325
THR B 327
PRO B 326
PRO B 178
 F7E  B 402 (-3.2A)
None
None
None
 1.29A 6a4iB-6gplB:
undetectable		 6a4iB-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 6gpl GDP-MANNOSE 4,6
DEHYDRATASE
(Homo
sapiens) 		3 / 3 ARG B 325
ARG B 214
ARG B 247
 F7E  B 402 (-3.2A)
F7E  B 402 (-2.8A)
F7E  B 402 (-3.2A)
 1.07A 6bplA-6gplB:
undetectable
6bplB-6gplB:
undetectable		 6bplA-6gplB:
undetectable
6bplB-6gplB:
undetectable