SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1p7lD-6gruA:
undetectable		 1p7lD-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1p7lC-6gruA:
undetectable		 1p7lC-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1rg9B-6gruA:
undetectable		 1rg9B-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.76A 1rg9A-6gruA:
undetectable		 1rg9A-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1rg9D-6gruA:
undetectable		 1rg9D-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.75A 1rg9C-6gruA:
undetectable		 1rg9C-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 7 GLU A 166
ARG A  84
GLU A 116
GLU A 112
 MG  A 302 ( 2.5A)
MG  A 301 ( 4.5A)
MG  A 301 ( 2.5A)
MG  A 302 (-2.5A)
 1.28A 2zt7A-6gruA:
undetectable		 2zt7A-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 12 THR A 117
PRO A  66
ILE A 123
VAL A 144
ILE A  65
 None
 1.18A 4eb6B-6gruA:
undetectable
4eb6C-6gruA:
undetectable		 4eb6B-6gruA:
11.60
4eb6C-6gruA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.78A 4ndnB-6gruA:
undetectable		 4ndnB-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.83A 4ndnD-6gruA:
undetectable		 4ndnD-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 GLU A 106
THR A  58
HIS A 142
 None
 0.62A 4q15A-6gruA:
undetectable		 4q15A-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 GLU A 106
THR A  58
HIS A 142
 None
 0.60A 4q15B-6gruA:
undetectable		 4q15B-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 110
LEU A 113
GLU A 114
ILE A 148
 None
 0.86A 4ww7A-6gruA:
undetectable		 4ww7A-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 GLU A 106
THR A  58
HIS A 142
 None
 0.63A 4ydqB-6gruA:
undetectable		 4ydqB-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 146
HIS A 142
VAL A  62
 None
 0.72A 5jmnC-6gruA:
undetectable		 5jmnC-6gruA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 4 GLU A 114
THR A 117
GLU A 112
HIS A 142
 None
None
MG  A 302 (-2.5A)
None
 1.36A 5utuF-6gruA:
undetectable		 5utuF-6gruA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		5 / 12 VAL A 193
LEU A 185
LEU A 178
ILE A  77
ALA A 201
 None
 1.39A 5xprA-6gruA:
undetectable		 5xprA-6gruA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A  51
ARG A  54
ASP A  60
 None
 0.97A 6d8pA-6gruA:
undetectable		 6d8pA-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.86A 6fbnA-6gruA:
undetectable		 6fbnA-6gruA:
undetectable