SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gsa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 6gsa -
(-) 		5 / 12 LEU E 186
LEU E 185
GLN E 219
LEU E 534
CYH E 349
 None
 1.47A 1a28A-6gsaE:
undetectable		 1a28A-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 6gsa -
(-) 		3 / 3 ASP E 312
ASP E 320
ASP E 456
 None
 0.76A 1eizA-6gsaE:
undetectable		 1eizA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 6gsa -
(-) 		3 / 3 ASP E 312
ASP E 320
ASP E 456
 None
 0.74A 1ej0A-6gsaE:
undetectable		 1ej0A-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 6gsa -
(-) 		5 / 9 CYH D 426
LEU D 476
ILE D 392
THR D 422
ILE D 418
 None
 1.36A 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable		 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 6gsa -
(-) 		5 / 9 THR D 422
ILE D 418
CYH D 426
LEU D 476
ILE D 392
 None
 1.35A 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable		 1hzeA-6gsaD:
undetectable
1hzeB-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 6gsa -
(-) 		5 / 10 CYH D 426
LEU D 476
ILE D 392
THR D 422
ILE D 418
 None
 1.40A 1i18A-6gsaD:
undetectable
1i18B-6gsaD:
undetectable		 1i18A-6gsaD:
undetectable
1i18B-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 6gsa -
(-) 		5 / 10 THR D 422
ILE D 418
CYH D 426
LEU D 476
ILE D 392
 None
 1.37A 1i18A-6gsaD:
undetectable
1i18B-6gsaD:
undetectable		 1i18A-6gsaD:
undetectable
1i18B-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.79A 1v54N-6gsaD:
undetectable
1v54W-6gsaD:
undetectable		 1v54N-6gsaD:
undetectable
1v54W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.84A 2dyrN-6gsaD:
undetectable
2dyrW-6gsaD:
undetectable		 2dyrN-6gsaD:
undetectable
2dyrW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 6 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.80A 2einN-6gsaD:
undetectable
2einW-6gsaD:
undetectable		 2einN-6gsaD:
undetectable
2einW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 6gsa -
(-) 		5 / 12 ILE E  53
LEU E 132
ASN E 130
ASN E 141
ILE E 146
 None
 1.02A 2nnhA-6gsaE:
undetectable		 2nnhA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 6gsa -
(-) 		5 / 10 ILE E  53
LEU E 132
ASN E 130
ASN E 141
ILE E 146
 None
 1.00A 2nnhB-6gsaE:
undetectable		 2nnhB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 6gsa -
(-) 		5 / 12 LEU E 215
LEU E 290
ALA E 287
LEU E 272
CYH E 281
 None
 1.31A 2oaxE-6gsaE:
undetectable		 2oaxE-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6gsa -
(-) 		5 / 12 TYR E 342
PHE E 338
PHE E 205
PRO E 333
THR E 285
 None
 1.32A 2x2nA-6gsaE:
undetectable		 2x2nA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.85A 3ablA-6gsaD:
undetectable
3ablJ-6gsaD:
undetectable		 3ablA-6gsaD:
undetectable
3ablJ-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 8 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.82A 3ablN-6gsaD:
undetectable
3ablW-6gsaD:
undetectable		 3ablN-6gsaD:
undetectable
3ablW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 6 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.78A 3ag1N-6gsaD:
undetectable
3ag1W-6gsaD:
undetectable		 3ag1N-6gsaD:
undetectable
3ag1W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6gsa -
(-) 		4 / 8 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.83A 3ag3N-6gsaD:
undetectable
3ag3W-6gsaD:
undetectable		 3ag3N-6gsaD:
undetectable
3ag3W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 6gsa -
(-) 		4 / 8 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.84A 3asnN-6gsaD:
undetectable
3asnW-6gsaD:
undetectable		 3asnN-6gsaD:
undetectable
3asnW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 6gsa -
(-) 		5 / 11 LEU E  90
ILE E 406
LYS E 410
SER E 411
PRO E 412
 None
 1.19A 3bjwB-6gsaE:
undetectable		 3bjwB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 6gsa -
(-) 		3 / 3 PRO E 322
PHE E 228
LYS E 233
 None
 1.26A 3bjwG-6gsaE:
undetectable		 3bjwG-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 6gsa -
(-) 		5 / 11 LEU E  90
ILE E 406
LYS E 410
SER E 411
PRO E 412
 None
 1.17A 3bjwH-6gsaE:
undetectable		 3bjwH-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.37A 3dqtA-6gsaE:
undetectable
3dqtB-6gsaE:
undetectable		 3dqtA-6gsaE:
undetectable
3dqtB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 6gsa -
(-) 		5 / 12 GLY D 479
TRP D 370
ILE D 440
LEU D 437
TYR D 423
 None
 1.15A 3eeoA-6gsaD:
undetectable		 3eeoA-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 6gsa -
(-) 		5 / 12 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.15A 3eeyA-6gsaE:
undetectable		 3eeyA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 6gsa -
(-) 		5 / 12 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.15A 3eeyB-6gsaE:
undetectable		 3eeyB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 6gsa -
(-) 		5 / 12 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.15A 3eeyF-6gsaE:
undetectable		 3eeyF-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 6gsa -
(-) 		5 / 12 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.17A 3eeyH-6gsaE:
undetectable		 3eeyH-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 6gsa -
(-) 		5 / 12 ASN E 143
ILE E 126
GLY E 127
ASN E 145
THR E 148
 None
 1.17A 3eeyI-6gsaE:
undetectable		 3eeyI-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6gsa -
(-) 		3 / 3 ASN D 107
HIS D 108
VAL D 165
 None
 0.56A 3elzB-6gsaD:
undetectable		 3elzB-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 6gsa -
(-) 		4 / 4 PRO D 353
THR D 329
GLY D 324
THR D 323
 None
 1.16A 3ib1A-6gsaD:
undetectable		 3ib1A-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 6gsa -
(-) 		4 / 7 SER E 232
ARG E 355
PHE E 359
GLU E 229
 None
 1.42A 3n5tA-6gsaE:
undetectable
3n5tB-6gsaE:
undetectable		 3n5tA-6gsaE:
undetectable
3n5tB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 6gsa -
(-) 		4 / 5 ILE E  94
HIS E 158
VAL E 154
HIS E  86
 None
 1.21A 3nneA-6gsaE:
undetectable		 3nneA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 6gsa -
(-) 		4 / 5 ILE E  94
HIS E 158
VAL E 154
HIS E  86
 None
 1.16A 3nneB-6gsaE:
undetectable		 3nneB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 6gsa -
(-) 		4 / 6 ILE E  94
HIS E 158
VAL E 154
HIS E  86
 None
 1.20A 3nneG-6gsaE:
undetectable		 3nneG-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6gsa -
(-) 		4 / 8 TYR D 131
LEU D  94
PHE D  28
TYR D 142
 None
 1.18A 3po7A-6gsaD:
undetectable		 3po7A-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 6gsa -
(-) 		5 / 12 ILE E 146
ALA E 144
LEU E  78
LEU E 132
ILE E  85
 None
 1.02A 3tq9A-6gsaE:
undetectable		 3tq9A-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 6gsa -
(-) 		4 / 4 LEU E 432
ILE E 484
TYR E 295
TYR E 498
 None
 1.36A 3vt7A-6gsaE:
undetectable		 3vt7A-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 6 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.86A 3wg7N-6gsaD:
undetectable
3wg7W-6gsaD:
undetectable		 3wg7N-6gsaD:
undetectable
3wg7W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 6gsa -
(-) 		5 / 11 PHE D 170
LEU D 127
LEU D 187
SER D 269
LEU D 179
 None
 1.21A 4dm8A-6gsaD:
undetectable		 4dm8A-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 6gsa -
(-) 		3 / 3 TYR D 423
ARG D 456
SER D 480
 None
 1.17A 4dr2I-6gsaD:
undetectable
4dr2J-6gsaD:
undetectable		 4dr2I-6gsaD:
undetectable
4dr2J-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.39A 4k5jA-6gsaE:
undetectable
4k5jB-6gsaE:
undetectable		 4k5jA-6gsaE:
undetectable
4k5jB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 6gsa -
(-) 		3 / 3 TYR D 423
ARG D 456
SER D 480
 None
 1.16A 4lf7I-6gsaD:
undetectable
4lf7J-6gsaD:
undetectable		 4lf7I-6gsaD:
undetectable
4lf7J-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 6gsa -
(-) 		3 / 3 TYR D 423
ARG D 456
SER D 480
 None
 1.16A 4lf8I-6gsaD:
undetectable
4lf8J-6gsaD:
undetectable		 4lf8I-6gsaD:
undetectable
4lf8J-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6gsa -
(-) 		5 / 7 LEU E 272
ASN E 225
LEU E 224
ARG E 221
LEU E 220
 None
 1.24A 4wg0B-6gsaE:
undetectable
4wg0C-6gsaE:
undetectable		 4wg0B-6gsaE:
undetectable
4wg0C-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.37A 5adlA-6gsaE:
undetectable
5adlB-6gsaE:
undetectable		 5adlA-6gsaE:
undetectable
5adlB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.82A 5b1bA-6gsaD:
undetectable
5b1bJ-6gsaD:
undetectable		 5b1bA-6gsaD:
undetectable
5b1bJ-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.83A 5b1bN-6gsaD:
undetectable
5b1bW-6gsaD:
undetectable		 5b1bN-6gsaD:
undetectable
5b1bW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.85A 5b3sN-6gsaD:
undetectable
5b3sW-6gsaD:
undetectable		 5b3sN-6gsaD:
undetectable
5b3sW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.36A 5fj3A-6gsaE:
undetectable
5fj3B-6gsaE:
undetectable		 5fj3A-6gsaE:
undetectable
5fj3B-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6gsa -
(-) 		4 / 6 CYH E 182
CYH E 349
HIS E 350
LEU E 351
 None
 1.10A 5hpuC-6gsaE:
undetectable
5hpuD-6gsaE:
undetectable		 5hpuC-6gsaE:
undetectable
5hpuD-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.81A 5iy5A-6gsaD:
undetectable
5iy5J-6gsaD:
undetectable		 5iy5A-6gsaD:
undetectable
5iy5J-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.81A 5iy5N-6gsaD:
undetectable
5iy5W-6gsaD:
undetectable		 5iy5N-6gsaD:
undetectable
5iy5W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 6 SER E 232
ARG E 355
PHE E 359
GLU E 229
 None
 1.38A 5uo8A-6gsaE:
0.0
5uo8B-6gsaE:
undetectable		 5uo8A-6gsaE:
undetectable
5uo8B-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.41A 5vv7A-6gsaE:
undetectable
5vv7B-6gsaE:
undetectable		 5vv7A-6gsaE:
undetectable
5vv7B-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.39A 5vvnA-6gsaE:
undetectable
5vvnB-6gsaE:
undetectable		 5vvnA-6gsaE:
undetectable
5vvnB-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 6 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.85A 5z86N-6gsaD:
undetectable
5z86W-6gsaD:
undetectable		 5z86N-6gsaD:
undetectable
5z86W-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 6 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.86A 5zcoN-6gsaD:
undetectable
5zcoW-6gsaD:
undetectable		 5zcoN-6gsaD:
undetectable
5zcoW-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 SER E 232
ARG E 355
PHE E 359
GLU E 229
 None
 1.34A 6av6A-6gsaE:
undetectable
6av6B-6gsaE:
undetectable		 6av6A-6gsaE:
undetectable
6av6B-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 PHE E 359
GLU E 229
SER E 232
ARG E 355
 None
 1.41A 6av6C-6gsaE:
undetectable
6av6D-6gsaE:
undetectable		 6av6C-6gsaE:
undetectable
6av6D-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gsa -
(-) 		4 / 7 SER E 232
ARG E 355
PHE E 359
GLU E 229
 None
 1.35A 6av7A-6gsaE:
undetectable
6av7B-6gsaE:
undetectable		 6av7A-6gsaE:
undetectable
6av7B-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6gsa -
(-) 		5 / 12 TYR E 332
LEU E 324
PHE E 205
VAL E 345
LEU E 226
 None
 1.16A 6djzA-6gsaE:
undetectable		 6djzA-6gsaE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.84A 6nmfA-6gsaD:
undetectable
6nmfJ-6gsaD:
undetectable		 6nmfA-6gsaD:
undetectable
6nmfJ-6gsaD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gsa -
(-) 		4 / 7 ILE D 320
MET D 361
THR D 360
LEU D 359
 None
 0.83A 6nmpA-6gsaD:
undetectable
6nmpJ-6gsaD:
undetectable		 6nmpA-6gsaD:
undetectable
6nmpJ-6gsaD:
undetectable