SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 7 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.89A 11gsA-6gswA:
25.7		 11gsA-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		5 / 10 TYR A   6
VAL A   9
ILE A 111
TYR A 115
PRO A 206
 None
None
GPS  A 221 (-4.5A)
None
None
 0.79A 13gsA-6gswA:
25.7		 13gsA-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 6 LEU A 158
LEU A  19
ILE A  75
GLU A 100
 None
 0.85A 1mt1A-6gswA:
undetectable
1mt1F-6gswA:
undetectable		 1mt1A-6gswA:
14.51
1mt1F-6gswA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 6 ILE A  75
GLU A 100
LEU A 158
LEU A  19
 None
 0.86A 1mt1B-6gswA:
undetectable
1mt1C-6gswA:
undetectable		 1mt1B-6gswA:
19.82
1mt1C-6gswA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 7 LEU A 158
LEU A  19
ILE A  75
GLU A 100
 None
 0.93A 1n13I-6gswA:
undetectable
1n13L-6gswA:
undetectable		 1n13I-6gswA:
14.51
1n13L-6gswA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.92A 2gssA-6gswA:
25.7		 2gssA-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.91A 2gssB-6gswA:
25.8		 2gssB-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 7 ILE A 207
ARG A 107
LEU A  18
ASP A 161
 None
 1.08A 2qqcB-6gswA:
undetectable
2qqcC-6gswA:
undetectable		 2qqcB-6gswA:
20.74
2qqcC-6gswA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		5 / 9 TYR A   6
VAL A   9
GLY A  11
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-3.5A)
GPS  A 221 (-4.5A)
None
 0.87A 3csjB-6gswA:
25.7		 3csjB-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.83A 3eeyC-6gswA:
undetectable		 3eeyC-6gswA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyD-6gswA:
undetectable		 3eeyD-6gswA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.83A 3eeyE-6gswA:
undetectable		 3eeyE-6gswA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
GLY A  11
ILE A 111
 None
None
GPS  A 221 (-3.5A)
GPS  A 221 (-4.5A)
 0.61A 3n9jB-6gswA:
25.6		 3n9jB-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 VAL A 152
TRP A 146
PHE A 183
PRO A  15
 None
 1.30A 3v35A-6gswA:
undetectable		 3v35A-6gswA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.98A 4k8cA-6gswA:
undetectable		 4k8cA-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.97A 4kanA-6gswA:
undetectable		 4kanA-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.97A 4kanB-6gswA:
undetectable		 4kanB-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 ILE A 207
MET A 197
ASP A 161
 None
 0.81A 5h2uA-6gswA:
undetectable		 5h2uA-6gswA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 7 LEU A  19
PHE A 157
ILE A 162
ASN A  73
 None
 0.90A 5n5dA-6gswA:
undetectable		 5n5dA-6gswA:
23.46