SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_CCSB417_0 (ESTROGEN RECEPTOR)	6gt1	SERINE/THREONINE-PRO TEIN KINASE NEK7 (Homo sapiens)	3 / 3	GLN A 144 LYS A 176 VAL A 167	None	0.88A	2jfaB-6gt1A: undetectable	2jfaB-6gt1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U8Q_A_NPUA7231_1 (LACTOTRANSFERRIN)	6gt1	SERINE/THREONINE-PRO TEIN KINASE NEK7 (Homo sapiens)	4 / 5	THR A 30 GLY A 27 PRO A 24 ASN A 33	None	1.06A	3u8qA-6gt1A: undetectable	3u8qA-6gt1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	6gt1	SERINE/THREONINE-PRO TEIN KINASE NEK7 (Homo sapiens)	5 / 10	GLY A 178 ILE A 40 LEU A 113 LEU A 111 ALA A 61	None F9N A 401 (-4.0A) F9N A 401 ( 4.9A) F9N A 401 ( 4.6A) F9N A 401 ( 4.2A)	0.96A	5l0zB-6gt1A: undetectable	5l0zB-6gt1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XOO_B_ADNB503_1 (GLYCOSAMINOGLYCAN XYLOSYLKINASE)	6gt1	SERINE/THREONINE-PRO TEIN KINASE NEK7 (Homo sapiens)	4 / 5	LEU A 226 VAL A 138 GLU A 135 LEU A 267	None	1.08A	5xooB-6gt1A: undetectable	5xooB-6gt1A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JFA_B_CCSB417_0","ESTROGEN RECEPTOR","6gt1","SERINE\/THREONINE-PROTEIN KINASE NEK7","Homo sapiens",3,"GLN A 144;LYS A 176;VAL A 167","None","0.88A","2jfaB-6gt1A:undetectable","2jfaB-6gt1A:undetectable"],["3U8Q_A_NPUA7231_1","LACTOTRANSFERRIN","6gt1","SERINE\/THREONINE-PROTEIN KINASE NEK7","Homo sapiens",4,"THR A  30;GLY A  27;PRO A  24;ASN A  33","None","1.06A","3u8qA-6gt1A:undetectable","3u8qA-6gt1A:undetectable"],["5L0Z_B_SAMB304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","6gt1","SERINE\/THREONINE-PROTEIN KINASE NEK7","Homo sapiens",5,"GLY A 178;ILE A  40;LEU A 113;LEU A 111;ALA A  61","None;F9N A 401 (-4.0A);F9N A 401 ( 4.9A);F9N A 401 ( 4.6A);F9N A 401 ( 4.2A)","0.96A","5l0zB-6gt1A:undetectable","5l0zB-6gt1A:undetectable"],["5XOO_B_ADNB503_1","GLYCOSAMINOGLYCAN XYLOSYLKINASE","6gt1","SERINE\/THREONINE-PROTEIN KINASE NEK7","Homo sapiens",4,"LEU A 226;VAL A 138;GLU A 135;LEU A 267","None","1.08A","5xooB-6gt1A:undetectable","5xooB-6gt1A:undetectable"]]