SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 6gu8 -
(-) 		5 / 12 VAL A  46
LEU A  40
ALA A 331
ILE A  60
ILE A  63
 None
 0.94A 1epbA-6gu8A:
undetectable		 1epbA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 6gu8 -
(-) 		5 / 12 VAL A  46
LEU A  40
ALA A 331
ILE A  60
ILE A  63
 None
 0.91A 1epbB-6gu8A:
1.8		 1epbB-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6gu8 -
(-) 		4 / 5 GLY A 353
ILE A 288
VAL A 340
SER A 326
 None
 1.24A 1rs7A-6gu8A:
undetectable		 1rs7A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6gu8 -
(-) 		5 / 12 ALA A 233
LEU A 253
VAL A 251
LEU A 186
ILE A 138
 None
 1.07A 1s9pD-6gu8A:
undetectable		 1s9pD-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 6gu8 -
(-) 		4 / 8 GLY A 169
GLU A 170
ALA A 171
THR A 188
 None
PEG  A 509 (-3.6A)
None
None
 0.77A 2dtjA-6gu8A:
undetectable
2dtjB-6gu8A:
undetectable		 2dtjA-6gu8A:
undetectable
2dtjB-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 6gu8 -
(-) 		5 / 12 ASP A 292
GLY A 294
MET A 322
PHE A 324
GLY A 284
 EDO  A 507 ( 4.7A)
None
None
None
None
 1.33A 2fqyA-6gu8A:
3.9		 2fqyA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 6gu8 -
(-) 		5 / 12 ASP A 292
GLY A 294
PHE A 324
GLY A 284
VAL A  68
 EDO  A 507 ( 4.7A)
None
None
None
None
 0.99A 2fqyA-6gu8A:
3.9		 2fqyA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6gu8 -
(-) 		6 / 12 ILE A 276
ILE A 277
ALA A 358
LEU A 338
ILE A 373
HIS A 392
 None
 1.47A 2h79A-6gu8A:
undetectable		 2h79A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 6gu8 -
(-) 		4 / 6 SER A 289
VAL A  68
TYR A 312
ASP A 325
 None
 1.26A 2x45A-6gu8A:
undetectable		 2x45A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 6gu8 -
(-) 		4 / 7 SER A 289
VAL A  68
TYR A 312
ASP A 325
 None
 1.25A 2x45B-6gu8A:
undetectable		 2x45B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 6gu8 -
(-) 		4 / 7 SER A 289
VAL A  68
TYR A 312
ASP A 325
 None
 1.24A 2x45C-6gu8A:
undetectable		 2x45C-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 6gu8 -
(-) 		4 / 6 ASN A 279
SER A 257
HIS A 398
ASP A 399
 None
PEG  A 511 (-2.4A)
PEG  A 509 ( 4.5A)
None
 1.15A 3aruA-6gu8A:
undetectable		 3aruA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 6gu8 -
(-) 		4 / 8 ILE A 206
LEU A 209
PHE A 210
ARG A  75
 None
 0.82A 3asnN-6gu8A:
undetectable
3asnW-6gu8A:
undetectable		 3asnN-6gu8A:
undetectable
3asnW-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6gu8 -
(-) 		5 / 9 SER A 134
THR A 140
VAL A 141
LEU A 116
ALA A 150
 EDO  A 505 ( 4.8A)
None
None
None
EDO  A 506 (-3.1A)
 1.46A 3ax7B-6gu8A:
0.7		 3ax7B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6gu8 -
(-) 		6 / 12 ILE A 276
ILE A 277
ALA A 358
LEU A 338
ILE A 373
HIS A 392
 None
 1.45A 3gwsX-6gu8A:
undetectable		 3gwsX-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 6gu8 -
(-) 		4 / 8 ILE A 264
ALA A 286
LEU A 338
ALA A 341
 None
 0.95A 3hrdA-6gu8A:
undetectable
3hrdB-6gu8A:
1.5		 3hrdA-6gu8A:
undetectable
3hrdB-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6gu8 -
(-) 		5 / 12 TYR A 315
TYR A 312
GLY A 285
ALA A 329
ILE A  63
 None
 1.40A 3ld6B-6gu8A:
undetectable		 3ld6B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6gu8 -
(-) 		5 / 12 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
 None
EDO  A 505 ( 4.9A)
None
None
None
 1.07A 3ou6A-6gu8A:
undetectable		 3ou6A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6gu8 -
(-) 		5 / 12 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
 None
EDO  A 505 ( 4.9A)
None
None
None
 1.08A 3ou6B-6gu8A:
undetectable		 3ou6B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6gu8 -
(-) 		5 / 12 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
 None
EDO  A 505 ( 4.9A)
None
None
None
 1.09A 3ou6C-6gu8A:
undetectable		 3ou6C-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6gu8 -
(-) 		5 / 12 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
 None
EDO  A 505 ( 4.9A)
None
None
None
 1.08A 3ou7B-6gu8A:
undetectable		 3ou7B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6gu8 -
(-) 		5 / 12 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
 None
EDO  A 505 ( 4.9A)
None
None
None
 1.08A 3ou7C-6gu8A:
undetectable		 3ou7C-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gu8 -
(-) 		4 / 5 GLY A 353
ILE A 288
VAL A 340
SER A 326
 None
 1.23A 4d33A-6gu8A:
undetectable		 4d33A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6gu8 -
(-) 		4 / 5 GLY A 353
ILE A 288
VAL A 340
SER A 326
 None
 1.19A 4d33B-6gu8A:
undetectable		 4d33B-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 6gu8 -
(-) 		4 / 5 GLY A 357
ALA A 286
PHE A 355
GLU A 354
 None
 1.00A 4m93B-6gu8A:
undetectable
4m93C-6gu8A:
undetectable		 4m93B-6gu8A:
undetectable
4m93C-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6gu8 -
(-) 		5 / 12 GLY A 232
ALA A 233
SER A 105
ASP A 238
PRO A  76
 None
 1.20A 4rtpA-6gu8A:
undetectable		 4rtpA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6gu8 -
(-) 		4 / 6 ALA A 329
LEU A 332
MET A 333
LEU A 338
 None
 1.06A 4xoyA-6gu8A:
undetectable		 4xoyA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6gu8 -
(-) 		4 / 6 ALA A 329
LEU A 332
MET A 333
LEU A 338
 None
 1.05A 4xp3A-6gu8A:
undetectable		 4xp3A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6gu8 -
(-) 		4 / 6 ILE A 206
LEU A 209
PHE A 210
ARG A  75
 None
 1.02A 5b1aN-6gu8A:
undetectable
5b1aW-6gu8A:
undetectable		 5b1aN-6gu8A:
undetectable
5b1aW-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6gu8 -
(-) 		5 / 9 SER A 278
ALA A 262
ALA A 230
GLY A 285
GLY A 284
 None
 0.98A 5d0xK-6gu8A:
undetectable
5d0xL-6gu8A:
undetectable		 5d0xK-6gu8A:
undetectable
5d0xL-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6gu8 -
(-) 		5 / 9 SER A 278
ALA A 262
ALA A 230
GLY A 285
GLY A 284
 None
 0.98A 5d0xY-6gu8A:
undetectable
5d0xZ-6gu8A:
undetectable		 5d0xY-6gu8A:
undetectable
5d0xZ-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 6gu8 -
(-) 		5 / 12 ASN A 301
TYR A 315
SER A 289
GLU A 283
TYR A  64
 None
 1.45A 5iqeC-6gu8A:
undetectable		 5iqeC-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6gu8 -
(-) 		4 / 6 ILE A  60
VAL A 364
VAL A  37
TRP A  52
 None
 0.96A 5jwaH-6gu8A:
undetectable		 5jwaH-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6gu8 -
(-) 		4 / 6 HIS A 398
VAL A 400
TYR A 408
HIS A 392
 PEG  A 509 ( 4.5A)
EDO  A 505 (-3.5A)
None
None
 1.28A 5kkzA-6gu8A:
undetectable
5kkzG-6gu8A:
0.3		 5kkzA-6gu8A:
undetectable
5kkzG-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6gu8 -
(-) 		4 / 7 HIS A 398
VAL A 400
TYR A 408
HIS A 392
 PEG  A 509 ( 4.5A)
EDO  A 505 (-3.5A)
None
None
 1.27A 5kkzK-6gu8A:
undetectable
5kkzQ-6gu8A:
undetectable		 5kkzK-6gu8A:
undetectable
5kkzQ-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6gu8 -
(-) 		4 / 7 HIS A 392
HIS A 398
VAL A 400
TYR A 408
 None
PEG  A 509 ( 4.5A)
EDO  A 505 (-3.5A)
None
 1.27A 5kkzM-6gu8A:
undetectable
5kkzO-6gu8A:
undetectable		 5kkzM-6gu8A:
undetectable
5kkzO-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6gu8 -
(-) 		5 / 11 ILE A 206
ILE A 194
ASP A 114
ILE A 102
ALA A 236
 None
None
EDO  A 506 (-3.4A)
None
None
 1.04A 5lg3A-6gu8A:
undetectable		 5lg3A-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6gu8 -
(-) 		5 / 12 ILE A 206
ILE A 194
ASP A 114
ILE A 102
ALA A 236
 None
None
EDO  A 506 (-3.4A)
None
None
 1.07A 5lg3E-6gu8A:
undetectable		 5lg3E-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 6gu8 -
(-) 		5 / 12 GLY A 353
GLY A 285
GLY A 282
ASP A 325
TYR A  64
 None
None
PEG  A 511 (-3.0A)
None
None
 1.18A 5x7fA-6gu8A:
undetectable		 5x7fA-6gu8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 6gu8 -
(-) 		4 / 6 GLU A  59
ARG A  56
LYS A  41
PRO A  35
 None
 1.43A 6fgdA-6gu8A:
3.3		 6fgdA-6gu8A:
undetectable