SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6gui -
(-) 		4 / 5 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.20A 1t88B-6guiA:
undetectable		 1t88B-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 6gui -
(-) 		4 / 7 TYR A 145
GLU A 211
TYR A 262
GLY A 208
 None
 1.16A 2ha4B-6guiA:
13.9		 2ha4B-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gui -
(-) 		4 / 5 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.23A 2m56A-6guiA:
undetectable		 2m56A-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 6gui -
(-) 		4 / 6 ARG A  67
THR A  62
ALA A  65
PRO A  11
 None
 1.42A 2ql8A-6guiA:
undetectable
2ql8B-6guiA:
undetectable		 2ql8A-6guiA:
undetectable
2ql8B-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6gui -
(-) 		5 / 12 ILE A  51
CYH A 167
ARG A 141
ILE A  49
MET A 204
 None
 1.29A 2xkwB-6guiA:
undetectable		 2xkwB-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6gui -
(-) 		4 / 5 PHE A 118
PHE A 121
LEU A  18
PHE A  16
 None
 1.39A 3abmC-6guiA:
undetectable
3abmJ-6guiA:
undetectable		 3abmC-6guiA:
undetectable
3abmJ-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6gui -
(-) 		4 / 5 PHE A 118
PHE A 121
LEU A  18
PHE A  16
 None
 1.38A 3abmP-6guiA:
undetectable
3abmW-6guiA:
undetectable		 3abmP-6guiA:
undetectable
3abmW-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6gui -
(-) 		5 / 9 VAL A 205
LEU A 183
ILE A 175
ALA A 241
ALA A 186
 None
 1.11A 3mdvA-6guiA:
undetectable		 3mdvA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6gui -
(-) 		5 / 12 PHE A 118
ILE A  28
ILE A  49
ALA A 143
GLY A 146
 None
 1.08A 3nxuA-6guiA:
undetectable		 3nxuA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 6gui -
(-) 		5 / 10 LEU A 119
VAL A 126
ILE A  28
GLY A  54
ILE A 122
 None
 1.02A 3oxwB-6guiA:
undetectable		 3oxwB-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 6gui -
(-) 		5 / 12 TYR A 149
GLY A 151
SER A 148
ILE A 175
LEU A 144
 None
 1.14A 3q87B-6guiA:
2.3		 3q87B-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 6gui -
(-) 		4 / 4 ASP A 100
THR A 102
VAL A  52
SER A  98
 None
 1.29A 3wxoA-6guiA:
undetectable		 3wxoA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gui -
(-) 		4 / 6 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.12A 4g3rA-6guiA:
undetectable		 4g3rA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6gui -
(-) 		5 / 12 LEU A 279
CYH A 167
VAL A 275
ALA A 154
SER A 206
 None
 1.30A 4iarA-6guiA:
undetectable		 4iarA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6gui -
(-) 		4 / 5 MET A 271
LEU A  57
ARG A  97
SER A 206
 None
 1.09A 4kmmB-6guiA:
2.6		 4kmmB-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gui -
(-) 		4 / 5 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.21A 4l49A-6guiA:
undetectable		 4l49A-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6gui -
(-) 		4 / 6 PHE A 165
LEU A 153
VAL A  52
VAL A 126
 None
 1.11A 4l4cA-6guiA:
undetectable		 4l4cA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 6gui -
(-) 		5 / 12 GLY A 146
ILE A  51
MET A 271
LEU A 144
LEU A 152
 None
 1.03A 4qdjA-6guiA:
undetectable		 4qdjA-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6gui -
(-) 		4 / 6 ASN A 124
GLU A 142
TYR A  50
PHE A 165
 None
 1.47A 4twdG-6guiA:
undetectable
4twdH-6guiA:
undetectable		 4twdG-6guiA:
undetectable
4twdH-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 6gui -
(-) 		4 / 5 LEU A 119
ASP A 120
LEU A 153
THR A 160
 None
 1.19A 4wozF-6guiA:
undetectable
4wozH-6guiA:
undetectable		 4wozF-6guiA:
undetectable
4wozH-6guiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6gui -
(-) 		5 / 9 ASN A 267
SER A 148
SER A 274
SER A 276
GLY A 278
 None
 1.07A 6awpA-6guiA:
undetectable		 6awpA-6guiA:
undetectable