SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6gun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 6gun -
(-) 		5 / 12 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.09A 1bsxA-6gunA:
undetectable		 1bsxA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 6gun -
(-) 		5 / 12 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.09A 1bsxB-6gunA:
undetectable		 1bsxB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 6gun -
(-) 		4 / 7 THR A  64
GLY A  58
ASP A  57
TYR A  98
 None
 1.02A 1bu5A-6gunA:
2.3		 1bu5A-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6gun -
(-) 		5 / 12 LEU A 288
GLY A 157
PHE A 160
TYR A  98
ALA A  60
 None
 1.14A 1tsnA-6gunA:
undetectable		 1tsnA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 6gun -
(-) 		4 / 8 TYR A  54
PHE A 172
PHE A 295
MET A 171
 None
 1.11A 1x8vA-6gunA:
undetectable		 1x8vA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 6gun -
(-) 		5 / 12 GLY A  80
GLY A  81
GLY A  82
PRO A  51
SER A  73
 None
 1.01A 1xdsA-6gunA:
undetectable		 1xdsA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 6gun -
(-) 		5 / 12 GLY A  80
GLY A  81
PRO A  51
ASP A 298
SER A  73
 None
 1.20A 1xdsA-6gunA:
undetectable		 1xdsA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 6gun -
(-) 		5 / 12 GLY A  80
GLY A  81
GLY A  82
PRO A  51
SER A  73
 None
 1.05A 1xdsB-6gunA:
undetectable		 1xdsB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 6gun -
(-) 		5 / 12 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.16A 2h77A-6gunA:
undetectable		 2h77A-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 6gun -
(-) 		4 / 7 TYR A 152
GLU A 224
TYR A 275
GLY A 221
 None
 1.25A 2ha4B-6gunA:
13.8		 2ha4B-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 6gun -
(-) 		4 / 8 ARG A 148
PRO A  43
GLY A  81
TRP A  38
 None
 0.84A 2qd3A-6gunA:
2.9		 2qd3A-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 6gun -
(-) 		3 / 3 GLU A 278
VAL A 283
CYH A 286
 None
 0.99A 3fbxA-6gunA:
undetectable		 3fbxA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 6gun -
(-) 		5 / 12 ALA A 122
ILE A 124
ASP A 127
LEU A 126
LEU A 159
 None
 1.23A 3lcvB-6gunA:
undetectable		 3lcvB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 6gun -
(-) 		5 / 12 PRO A 300
VAL A 270
ASP A 173
PRO A 214
LEU A 165
 None
 0.97A 3m6vA-6gunA:
undetectable		 3m6vA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 6gun -
(-) 		5 / 12 PRO A 300
VAL A 270
ASP A 173
PRO A 214
LEU A 165
 None
 0.99A 3m6vB-6gunA:
undetectable		 3m6vB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 6gun -
(-) 		5 / 12 TYR A 156
GLY A 158
SER A 155
ILE A 182
LEU A 151
 None
 1.05A 3q87B-6gunA:
undetectable		 3q87B-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6gun -
(-) 		4 / 8 PHE A 160
ILE A 189
GLU A 192
LEU A 126
 None
 0.81A 3rqwI-6gunA:
undetectable
3rqwJ-6gunA:
undetectable		 3rqwI-6gunA:
undetectable
3rqwJ-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6gun -
(-) 		3 / 3 TYR A 219
MET A 218
ILE A 189
 None
 0.82A 4c8bB-6gunA:
undetectable		 4c8bB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6gun -
(-) 		5 / 11 LEU A 288
GLY A 157
PHE A 160
TYR A  98
ALA A  60
 None
 1.19A 4fogD-6gunA:
undetectable		 4fogD-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6gun -
(-) 		5 / 12 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.17A 4lnwA-6gunA:
undetectable		 4lnwA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6gun -
(-) 		5 / 12 ILE A  87
ARG A 134
ALA A 164
LEU A 151
LEU A 107
 None
 1.17A 4lnxA-6gunA:
undetectable		 4lnxA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 6gun -
(-) 		5 / 11 LEU A 107
LEU A 125
ILE A 129
LEU A 126
ILE A  53
 None
 1.06A 4odrA-6gunA:
undetectable
4odrB-6gunA:
undetectable		 4odrA-6gunA:
undetectable
4odrB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 153
ILE A  55
MET A 284
LEU A 151
LEU A 159
 None
 1.00A 4qdjA-6gunA:
undetectable		 4qdjA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 6gun -
(-) 		4 / 6 ARG A  72
ARG A 290
ASP A  75
ASP A 298
 None
 1.21A 4xqeA-6gunA:
undetectable		 4xqeA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 6gun -
(-) 		4 / 6 ARG A  72
ARG A 290
ASP A  75
ASP A 298
 None
 1.22A 4xqeB-6gunA:
undetectable		 4xqeB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 6gun -
(-) 		4 / 8 GLY A  82
GLY A  81
VAL A 144
HIS A  37
 None
None
None
GOL  A 401 (-3.0A)
 0.80A 5f8yA-6gunA:
undetectable		 5f8yA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 6gun -
(-) 		5 / 9 ASP A 106
VAL A 116
TYR A 156
LEU A 107
GLY A 104
 None
 1.31A 5o45A-6gunA:
undetectable
5o45B-6gunA:
undetectable		 5o45A-6gunA:
undetectable
5o45B-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.13A 5vooA-6gunA:
undetectable		 5vooA-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.11A 5vooB-6gunA:
undetectable		 5vooB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.14A 5vooC-6gunA:
undetectable		 5vooC-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.10A 5vooD-6gunA:
undetectable		 5vooD-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.06A 5vooE-6gunA:
undetectable		 5vooE-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.07A 5vooF-6gunA:
undetectable		 5vooF-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6gun -
(-) 		5 / 12 GLY A 104
ASP A  57
LEU A 151
GLY A 158
SER A 181
 None
 1.07A 5vopB-6gunA:
undetectable		 5vopB-6gunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6gun -
(-) 		5 / 9 ILE A 182
SER A 273
SER A 179
SER A 155
GLY A 158
 None
 1.43A 6awpA-6gunA:
undetectable		 6awpA-6gunA:
undetectable